A5023110820- Diabetes Treatment and Management
- Diabetes and associated disorders
- Diabetes Management and Research
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neuropeptides and Animal Physiology
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Ideological and Political Education
- Cardiac Imaging and Diagnostics
- Glycosylation and Glycoproteins Research
- HIV Research and Treatment
- Cardiovascular Function and Risk Factors
- Education and Learning Interventions
- Protein purification and stability
- Pediatric health and respiratory diseases
- MicroRNA in disease regulation
- Diagnosis and treatment of tuberculosis
- Cytokine Signaling Pathways and Interactions
- Gout, Hyperuricemia, Uric Acid
- RNA modifications and cancer
- Diet, Metabolism, and Disease
Xinjiang Medical University
2016-2023
Second Affiliated Hospital of Guangzhou Medical University
2016-2023
Guangzhou Medical University
2016-2023
Central South University
2013-2021
Second Xiangya Hospital of Central South University
2013-2021
Karolinska Institutet
2021
Xinjiang Uygur Autonomous Region Uygur Medicine Hospital
2021
Innovative Research (United States)
2013
Harvard University
1998
Dipeptidyl peptidase 4 (DPP-4) inhibitors have been widely used in type 2 diabetes. An important unanswered question concerns the effect of DPP-4 inhibition on β-cell function patients with autoimmune diabetes.The objective study was to investigate effects inhibitor recent-onset latent diabetes adults (LADA).This an open-label, randomized-controlled conducted Department Endocrinology at Second Xiangya Hospital.Thirty recently diagnosed LADA were randomized 1:1 receive insulin therapy 100...
OBJECTIVE This study investigated the relationship between GAD autoantibody (GADA) titers and changing of β-cell function in patients with latent autoimmune diabetes adults (LADA). RESEARCH DESIGN AND METHODS 3-year prospective enrolled 95 subjects from 15 Chinese cities including 25 high-titer (GADA ≥180 units/mL) LADA patients, 42 low-titer <180 28 type 2 diabetic latter two groups as controls similar age, sex, BMI. Clinical characteristics were determined annually, glycosylated...
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of anti-diabetic agents that widely used in clinical practice to improve glycemic control and protect β-cell function patients with type 2 diabetes. DPP-4 is also known as lymphocyte cell surface protein CD26 plays an important role T-cell immunity. Autoimmune diabetes, mediated organ-specific disease, initiated by the imbalance between pathogenic regulatory T-lymphocytes. can suppress effects Th1 Th17 cells up-regulate Th2 T cells,...
The seven-transmembrane CCR5 was recently found to double as a coreceptor for genetically diverse family of human and nonhuman primate lentiviruses. Paradoxically, the main region envelope protein believed be involved in utilization mapped hypervariable 3, or V3, glycoprotein gp120. In this study, we addressed question whether functional convergence is mediated by certain V3 residues that are highly conserved among HIV type 1 (HIV-1), 2, simian immunodeficiency virus. Site-directed...
Abstract Context The long-term effects of dipeptidyl peptidase-4 inhibitors on β-cell function and insulin sensitivity in latent autoimmune diabetes adults (LADA) are unclear. Objective To investigate the sitagliptin LADA patients receiving insulin. Design Setting A randomized controlled trial at Second Xiangya Hospital. Methods Fifty-one with were to + (SITA) group or alone (CONT) for 24 months. Main Outcome Measures Fasting C-peptide (FCP), 2-hour postprandial (2hCP) during mixed-meal...
The network platform is used in many professional teachings for its fastness and interaction. use of immunology PBL (Problem Based Learning) teaching can break through the limitation time space teachers’ strength. Students interact with tutors anytime anywhere to find information cases, which helpful development teaching. As a kind modern mode, improves method teachers, effectively assists classroom teaching, students’ ability acquire knowledge independently.
The most commonly used strains in experimental research, including genetically modified strains, are C57BL/6 mice. However, so far, no reliable model for rheumatoid arthritis is available, mainly due to the restriction by MHC class II haplotype H-2 b . Collagen-induced (CIA) widely animal of arthritis, but strain resistant CIA because there collagen peptide associated with To establish a mice, we immunized C57BL/6NJ (B6N) mice human cartilage oligomeric matrix protein (COMP), which induced...
Type 1 diabetes is a T cell-mediated autoimmune disease. Interferon γ plays critical role in the pathogenesis of type diabetes. Signal transducer and activator transcription transduces I interferon cytokines cells, leading to Th1 cell differentiation production γ. Recent studies suggest that liraglutide reduces plasma concentration C-reative protein patients with protects β function non-obese diabetic mouse.The study aimed explore effect glucagon-like peptide-1 analogue on underlying...
Patient-centered care is respectful to a patient's preference. All prior clinical trials on patient self-titration algorithms for basal insulin were decided by physicians. We hypothesized that patients and physicians have different preferences.Physicians diabetes asked choose their preferred glargine algorithm among 5 algorithms. Algorithm 1, 1 U increase once daily; 2, 2 every 3 days; 3, 4, titration days according fasting blood glucose, 5, weekly 2-8 based 3-day mean glucose levels.Eleven...
To study the interaction effects of rs10757278 polymorphisms at 9p21 locus and traditional risk factors on coronary heart disease (CHD) in Xinjiang, China.This case-control consecutively enrolled 310 unrelated consecutive CHD patients aged 18-70 years old. All participants were recruited between January December 2017 from The Heart Center First Affiliated Hospital Xinjiang Medical University. confirmed by angiography (≥50% diameter stenosis least one major arteries) according to American...
In 1936, Himworth first investigated insulin resistance and non-insulin in diabetes. Then the terminology "type 1 diabetes (T1D)" 2 (T2D)" were used 1951. 1999, World Health Organization (WHO) announced classification of diabetes: as we all known, T1D T2D.1 This is widely accepted used. However, clinical practice, it quite often to find some patients cannot be simply diagnosed or T2D. 1974, islet autoantibodies discovered sera T1D, which provided strong evidence prove that an autoimmune...
Introduction Subcutaneous administration of insulin is the preferred method for achieving glucose control in non-critically ill patients with diabetes. Glucose-based titration protocols were widely applied clinical practice. However, most these algorithms are experience-based and there considerable variability complexity. This study aimed to compare effectiveness safety a weight-based algorithm versus glucose-based hospitalized type 2 diabetes mellitus (T2DM). Research design methods...
To study the correlation between occupational stress and coronary heart disease in western China.A case-control design was used. From June 2016 to May 2017, 310 patients with (CHD) confirmed by angiography (CAG) at Heart Center of First Affiliated Hospital Xinjiang Medical University were recruited cluster sampling, along 536 healthy controls. The questionnaire developed based on a Job Content Questionnaire (JCQ). An epidemiological survey conducted collect clinical data. Chi-squared test,...
Objective To analyze serum levels of inhibitory costimulatory molecules and their correlations with innate immune cytokine in patients pulmonary tuberculosis (PTB). Methods Data for 280 PTB healthy individuals were collected. Serum measured using ELISA. Univariate, multivariate, subgroup, matrix correlation, receiver operating characteristic curve analyses performed. Results Host, environment, lifestyle, clinical features, medical history all influenced PTB. soluble programmed death ligand 1...
Clinical microbiological examination technology is an important professional course for medical laboratory students. Through the teaching of "Internet + education" "MOOCs" in classroom and rain class, it stimulates students' interest learning improves their self-learning ability. The effectiveness has increased interaction between teachers class also inspired formative evaluation ultimately improved quality teaching.
Non-government college run not for a long time. The students have poor foundation, learning habits is weak. Then we need to update the concept of education, must putting first. Change traditional teaching philosophy, methods and skills up conscious mode. To improve effectiveness teach actually. basic requirement deepening curriculum reform private University, 'lifeline' university teaching. KEYWORD: colleges; educational idea; mode; try; effectiveness; lifeline.