A5103185531- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Synthesis and Reactions of Organic Compounds
- Immune Cell Function and Interaction
- Fluorine in Organic Chemistry
- Synthesis and Biological Evaluation
- Chemical Synthesis and Analysis
- Diabetes Treatment and Management
- Asymmetric Synthesis and Catalysis
- T-cell and B-cell Immunology
- Hemodynamic Monitoring and Therapy
- Peroxisome Proliferator-Activated Receptors
- Synthesis and pharmacology of benzodiazepine derivatives
- HIV/AIDS drug development and treatment
- Synthesis of Organic Compounds
- Asthma and respiratory diseases
- Synthetic Organic Chemistry Methods
- Adipokines, Inflammation, and Metabolic Diseases
- Synthesis of heterocyclic compounds
- Cardiac, Anesthesia and Surgical Outcomes
- Quinazolinone synthesis and applications
- Coordination Chemistry and Organometallics
- Parvovirus B19 Infection Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
Molecular Sciences Institute
2025
Central South University
2014-2023
Second Xiangya Hospital of Central South University
2014-2023
National Clinical Research Center for Digestive Diseases
2021-2022
China Medical University
2015
National Clinical Research
2015
Eli Lilly (United States)
2015
Yale University
2010
Lehigh Valley Hospital-Pocono
2008
Pennsylvania State University
2008
Adult non-insulin requiring diabetes includes latent autoimmune of adults (LADA), distinguished from type 2 by the presence islet autoantibodies. LADA China determined characteristics Chinese LADA. This nationwide, multicenter, clinic-based cross-sectional study was conducted in 46 university-affiliated hospitals 25 cities. All 4,880 ketosis-free diabetic patients (<1 year postdiagnosis, without insulin therapy for >6 months, aged ≥30 years) had GAD antibody (GADA) and HLA-DQ genotype...
Dipeptidyl peptidase 4 (DPP-4) inhibitors have been widely used in type 2 diabetes. An important unanswered question concerns the effect of DPP-4 inhibition on β-cell function patients with autoimmune diabetes.The objective study was to investigate effects inhibitor recent-onset latent diabetes adults (LADA).This an open-label, randomized-controlled conducted Department Endocrinology at Second Xiangya Hospital.Thirty recently diagnosed LADA were randomized 1:1 receive insulin therapy 100...
OBJECTIVE B lymphocytes play an important role in the immunopathogenesis of autoimmune diabetes. We hypothesized that altered B-cell subset phenotype is associated with RESEARCH DESIGN AND METHODS Patients type 1 diabetes (T1D) (n = 81), latent adults (LADA) 82), or 2 (T2D) 95) and healthy control subjects 218) normal glucose tolerance (NGT) were recruited. determined percentage circulating B-lymphocyte subsets, including CD19+CD23−CD21+ (marginal zone [MZB]), CD19+CD23+CD21− (follicular...
OBJECTIVE This study investigated the relationship between GAD autoantibody (GADA) titers and changing of β-cell function in patients with latent autoimmune diabetes adults (LADA). RESEARCH DESIGN AND METHODS 3-year prospective enrolled 95 subjects from 15 Chinese cities including 25 high-titer (GADA ≥180 units/mL) LADA patients, 42 low-titer &lt;180 28 type 2 diabetic latter two groups as controls similar age, sex, BMI. Clinical characteristics were determined annually, glycosylated...
Abstract Context: The discrepancies in terms of human leukocyte antigen (HLA)-DRB1-DQA1-DQB1 conferred risks between latent autoimmune diabetes adults (LADA) and type 1 (T1D) patients remained almost completely unknown. goal the current study is to determine compare HLA-conferred LADA T1D. Design: A case-control was conducted a representative Chinese data set containing 520 T1D patients, 562 1065 controls. frequencies odds ratios for HLA susceptible haplotypes genotypes arginine at residue...
To determine the relationship between selected cytokines and diabetes in Chinese subjects.Adult patients with recent-onset type 1 (n=53), latent autoimmune adults (LADA) (n=250), 2 (n=285) from multiple centers were compared normal subjects (n=196). We centrally tested serum GAD antibodies (GADAs), interleukin-6 (IL-6), lipocalin (LCN2), high-sensitivity C-reactive protein (hs-CRP), adiponectin.After adjustment for age, sex, BMI, all types had increased IL-6 LCN2 (P<0.01), four LADA...
The ZnT8A is an independent marker for diagnosis of type 1 diabetes mellitus. We investigated the distribution and clinical features positive latent autoimmune in adult (LADA) patients to explore potential diagnostic application.A total 3062 phenotypic T2DM were randomly selected from a national multicenter study - LADA China Study. Radioligand binding assays applied detect presence ZnT8A, GADA IA-2A. HbA1c , fasting C-peptide serum lipid levels followed up with patients.The prevalence IA-2A...
Latent autoimmune diabetes in adults (LADA) is a form of with heterogeneous features. This study aimed to investigate the persistent status glutamic acid decarboxylase antibody (GADA) patients LADA and its association clinical characteristics.This 3-year follow-up enrolled 107 40 type 2 mellitus (T2DM) from October 2005 December 2013. GADA titer, epitopes, characteristics (including fasting C-peptide HbA1c ) were assayed annually. The human leukocyte antigen DQ (HLA-DQ) genotypes also...
Abstract Disease modifying therapies aiming to preserve β-cell function in patients with adult-onset autoimmune type 1 diabetes are lacking. Here, we conducted a multi-centre, randomized, controlled trial assess the preservation effects of saxagliptin alone and combined vitamin D as adjunctive diabetes. In this 3-arm trial, 301 participants were randomly assigned 24-month course conventional therapy (metformin or without insulin) plus therapy. The primary endpoint was change from baseline 24...
Adult-onset autoimmune diabetes is prevalent in China, contrast to childhood-onset type 1 mellitus. Islet autoantibodies are the most important immune biomarkers diagnose diabetes. We assayed four different islet recently diagnosed adult non-insulin-requiring Chinese subjects investigate best antibody assay strategy for correct diagnosis of these subjects.LADA China study a nation-wide multicenter conducted patients from 46 university-affiliated hospitals China. Non-insulin-treated newly (n...
An efficient Z‐selective cobalt‐catalyzed reductive hydroalkylation of terminal aryl alkynes with unactivated alkyl iodides has been achieved, providing a straightforward and modular route to access 1,2‐disubstituted Z‐styrenes. This reaction operates under mild conditions without requiring over‐stoichiometric amounts metal reductants. Excellent Z/E ratios good excellent yields can be achieved for diverse complex scaffolds remarkable functional‐group compatibility. One potential utility this...
Abstract Objective To explore the decline pattern and possible determinants of beta-cell function progression in patients with latent-onset autoimmune diabetes adults (LADA). Research Design Methods In this 8-year prospective study, 106 LADA individuals underwent annual follow-up their was assessed. Beta-cell failure defined by fasting C-peptide (FCP) &lt; 75 pmol/L. Other clinical characteristics, including age onset, body mass index (BMI), glutamic acid decarboxylase autoantibody...
Abstract Background Latent autoimmune diabetes in adults (LADA) exhibits significant clinical heterogeneity, but the underlying causes remain unclear. The aim of this study was to investigate whether age onset LADA contributes observed heterogeneity by comparing clinical, metabolic, and immunogenetic characteristics between elderly young patients. Methods cross‐sectional included a total 579 patients with which further divided into (E‐LADA) group (n = 135, ≥60 years) (Y‐LADA) 444, <60...
T lymphocytes are key players in the pathogenesis of autoimmune diabetes. We recruited subjects with T1D (n=81), LADA (n=82), T2D (n=95) and NGT (n=218) analyzed percentages T-lymphocyte subsets, including helper 1 (Th1), 2 (Th2), 17 (Th17), cytotoxic (Tc1), regulatory cells (Tregs), effector (Teff), naïve T, central memory (Tcm), (Tem) by flow cytometry. patients possessed similar frequencies IFN-γ+CD4+ IFN-γ+CD8+ CD4+ Teff compared patients, but much lower than those subjects. Like had...
Abstract Latent autoimmune diabetes in adults ( LADA ) is a form of with features both type 1 and 2 the middle spectrum. Scientists clash on question whether this unique subtype. Multicenter studies have been performed different countries, including K orea N ational D iabetes P rogram KNDP collaboratory group, E hime study J apan, ot I nsulin‐ R equiring A utoimmune NIRAD taly, ord‐ T røndelag H ealth HUNT orway, UK rospective S tudy UKPDS , ction urope C hina hina. These found universal...
B lymphocytes are involved in inflammation and related to insulin resistance obesity type 2 diabetes (T2D). This study investigated the phenotype frequency of B-lymphocyte subsets subjects recently diagnosed with T2D (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>60</mml:mn></mml:math>), impaired glucose regulation (IGR,<mml:math id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>73</mml:mn></mml:math>), normal tolerance...
Abstract Background There are abundant variations in the phenotypes and genetics of type 1 diabetes (T1D) patients across different races. This study aimed to assess differences between juvenile acute onset (JAO) adult Chinese T1D patients. Methods Seven hundred fifty‐one were divided into two groups by patient age as follows: group (≤20 years, JAO group) (>20 AAO group). Clinical characteristics, islet autoantibodies, HLA class II haplotypes genotypes compared these groups. Results In...
Metabolic Syndrome (MetS) is a high risk factor for Cardiovascular Diseases (CVD). We estimated to investigate how MetS prevalence by glucose homeostasis varies across different age and gender groups.We studied 9257 Chinese subjects over the of 15 years in two cross-sectional surveys 2006. With oral tolerance test (OGTT) test, 2341 were normal (NGT), 5448 diagnosed as having type 2 diabetes (T2D). All other 1468 considered be impaired fasting (IFG) or (IGT) subjects. Diabetes was diagnosis...
Objective Fulminant type 1 diabetes may uniquely occur as a fatal adverse event during immune checkpoint inhibitor (ICI) therapy. We investigated the clinical and immunological characteristics of ICI-associated fulminant (IFD). Research design methods enrolled 80 patients with IFD (77 cases from literature), 56 (IT1D) (55 45 traditional (TFD), 43 acute-onset for comprehensive analysis including islet autoantibodies subgroup based on ethnic origin. Results Patients accounted 58.8% (80/136)...