A5018017159- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Dementia and Cognitive Impairment Research
- Cardiac electrophysiology and arrhythmias
- Functional Brain Connectivity Studies
- Glaucoma and retinal disorders
- Advanced Neuroimaging Techniques and Applications
- Pancreatitis Pathology and Treatment
- Glioma Diagnosis and Treatment
- Retinal Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Gastric Cancer Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Esophageal Cancer Research and Treatment
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Metastasis and carcinoma case studies
- Blood Pressure and Hypertension Studies
- Diabetes Management and Research
- Adipose Tissue and Metabolism
- Radiation Dose and Imaging
- Esophageal and GI Pathology
- Alzheimer's disease research and treatments
Shanghai Chest Hospital
2013-2025
Shanghai Jiao Tong University
2010-2025
Xuzhou Medical College
2015-2025
Wenzhou Medical University
2025
Nanjing Sport Institute
2019-2025
General Hospital of Shenyang Military Region
2022-2024
Air Force General Hospital PLA
2024
Nanchang University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Beijing Normal University
2014-2023
Diabetes mellitus (DM) patients experience memory and cognitive deficits. The mechanisms underlying this dysfunction in the brain of DM are not fully understood, therefore, no optimized therapeutic strategy has been established so far. aim present study was to assess whether irisin able improve performance a streptozotocin-induced diabetic mouse model. A model behavioral tests were performed. We also set up primary cultures for mechanism studies. Western blots EMSA used molecular Significant...
OBJECTIVE Type 2 diabetes mellitus (T2DM) has important effects on cognition and the risk for Alzheimer disease (AD). Working memory (WM) is a susceptible cognitive domain of mild impairment AD. Thus, identification brain activation patterns under different WM loads can potentially enhance our understanding mechanisms underlying dysfunction in T2DM. RESEARCH DESIGN AND METHODS The current study assessed T2DM performance explored related neuronal damage through visual n-back task functional...
BACKGROUND Meteorin-like (Metrnl) is a novel adipomyokine that may improve glucose tolerance and affect insulin resistance. This study aimed to investigate the association between serum levels of Metrnl with blood status its MATERIAL AND METHODS The included 160 subjects normal (NGT) (n=40), impaired fasting (IFG) (IGT) newly diagnosed type 2 diabetes mellitus (T2DM) (n=40). An enzyme-linked immunosorbent assay (ELISA) was used measure Metrnl. Partial correlation analysis analyze...
Background: Escitalopram and sertraline are first‐line medications for treating depression. They belong to selective serotonin reuptake inhibitors (SSRIs) widely used due their effectiveness fewer side effects. However, despite the significant efficacy of escitalopram sertraline, there is a large variation among individuals. Therefore, predicting symptom improvement based on baseline period crucial. Methods: In this study, we conducted functional connectivity (FC) analysis...
Objective This study examined the accuracy of smartwatches in predicting running performance. Methods A total 154 amateur runners (123 males and 31 females) were recruited. After wearing HUAWEI WATCH GT Runner for a minimum six weeks, runners' actual completion times 5 km, 10 half marathon distances measured, resulting 288 test instances. The predicted same displayed on watch day recorded simultaneously. Results performances 5, 10, 21.1 km highly correlated, with r ≥ 0.95 ( p < 0.001)...
Despite extensive research on the epidemiological risk factors linking diabetes and carotid plaques, evidence regarding sex-specific differences remains scarce. This study aims to investigate gender in association between fasting blood glucose levels of plaques among cardiovascular high-risk populations. used cross-sectional data from a large prospective cohort study. From 2019 2020, ultrasound examinations were conducted populations pilot area. The independent variable was glucose,...
Physical inactivity among older adults is increasing globally. Analyzing the characteristics and influencing factors of physical activity patterns (PAPs) can inform design targeted (PA) promotion strategies for diverse subgroups. Analysis national data from 2020 revealed three distinct PAPs Chinese across life domains: low (LA) cluster (53.3%), active leisure (AL) (31.4%), home (AH) (15.3%). The AL demonstrated superior psychological status, fitness, built environment conditions compared to...
Current guidelines for the optimal ablation strategy persistent atrial fibrillation(PerAF) remain unclear. While our previous RCT confirmed favorable prognosis of aggressive ablation, real-world evidence is still lacking. Among 4,833 PerAF patients undergoing catheter at 10 centers, two groups were defined: Regular Ablation(PVI-only or PVI plus anatomical ablation) and Aggressive Ablation(anatomical electrogram-guided ablation), with 1,560 each after propensity score(PS) matching. The...
Objective To evaluate the predictive value of dual-energy CT angiography (DECTA) parameters carotid intraplaque and perivascular adipose tissue (PVAT) in acute stroke events. Methods A retrospective analysis was conducted using clinical, laboratory, imaging data from patients who underwent CTA cranial MRI. Acute cerebral infarctions occurring ipsilateral anterior circulation were classified as symptomatic group (STA group), while other cases categorized asymptomatic (ATA group). LASSO...
Abstract Background Delayed‐onset muscle soreness (DOMS) is a prominent factor that contributes to the decline in athletic performance. However, there an ongoing debate regarding efficacy of intermittent pneumatic compression (IPC) preventing or treating exercise‐induced injuries such as DOMS. Objective To characterize therapeutic effect IPC on DOMS induced by plyometric exercise. Design Randomized controlled trial. Setting Department Sport and Health Sciences, Nanjing Institute....
OBJECTIVESTo study the feasible and safe volume threshold for chest tube removal following video-assisted thoracoscopic surgical lobectomy.
Brain disconnection model has been proposed as a possible neural mechanism for cognitive aging. However, the relationship between structural connectivity degeneration and decline with normal aging remains unclear. In present study, using diffusion MRI tractography techniques, we report graph theory-based analyses of brain connectome in cross-sectional, community-based cohort 633 cognitively healthy elderly individuals. Comprehensive neuropsychological assessment subjects was performed. The...
Background: Deep learning (DL) could predict isocitrate dehydrogenase (IDH) mutation status from MRIs. Yet, previous work focused on CNNs with refined tumor segmentation. To bridge the gap, this study aimed to evaluate feasibility of developing a Transformer-based network IDH free Methods: A total 493 glioma patients were recruited two independent institutions for model development (TCIA; N = 259) and external test (AHXZ; 234). was predicted directly T2 images Swin Transformer conventional...
Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Although treatment options for AF exist, many patients cannot be maintained in normal sinus rhythm. Amiodarone an effective medication but has limited clinical utility because of off-target tissue toxicity. Methods: Here, we use a pig model to test efficacy amiodarone-containing polyethylene glycol–based hydrogel. The gel placed directly on atrial epicardium through pericardial space minimally invasive procedure...
The purposes of this study were to evaluate the mental health among patients with diabetic retinopathy (DR) and explore its' influencing factors. A cross-sectional survey was conducted in Liaoning Province, China. total 200 volunteered participate survey. Psycho-social variables included stress, self-efficacy, resilience, social support. logistic regression analysis used effect psycho-social factors on depression anxiety DR patients. prevalence 25% 13.5% Regression showed that support had a...
Age is the major risk factor for Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, there limited evidence about MCI-specific aging-related simultaneous changes of brain structure their impact on cognition. We analyzed imaging data from 269 subjects (97 MCI patients 172 cognitively normal [CN] elderly) using voxel-based morphometry tract-based spatial statistics procedures to explore special structural pattern during aging. found that with showed accelerated age-related...
Normal aging is accompanied by structural degeneration and glucose hypometabolism in the human brain. However, relationship between network disconnections normal remains largely unknown. In present study, combining MRI PET techniques, we investigated metabolic mechanism of brain connectome its with a cross-sectional, community-based cohort 42 cognitively elderly individuals aged 57-84 years. The was constructed based on diffusion tractography, efficiency metrics were quantified using graph...
Abstract Background Aortic stiffness shares a similar profile of risk factors with left ventricular hypertrophy (LVH) and can also lead to LVH by itself. Published data have demonstrated the correlation between aortic LVH. Recent revealed estimated pulse wave velocity (ePWV) be simple cost-effective marker severity stiffness. Our analysis aimed explore association ePWV prevalence, investigate incremental value for identification prevalence. Methods The present based on cross-sectional survey...
Atrial fibrillation (AF) is the most common arrhythmias, which significantly jeopardizes global cardiovascular health through complicated heart failure and stroke. Published studies have demonstrated impact of insulin resistance on genesis AF. Hence, monitoring may be a possible way to improve detection early-stage Accordingly, our work aimed investigate association between TyG, surrogate resistance, prevalent AF, evaluate potential TyG refine AF in diabetic population.This cross-sectional...