A5043608846- Nanoplatforms for cancer theranostics
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- biodegradable polymer synthesis and properties
- RNA Interference and Gene Delivery
- Carbon dioxide utilization in catalysis
- Dendrimers and Hyperbranched Polymers
- Erythrocyte Function and Pathophysiology
- Polymer Surface Interaction Studies
- Cancer therapeutics and mechanisms
- Synthetic Organic Chemistry Methods
- Graphene and Nanomaterials Applications
- Advanced Drug Delivery Systems
- Ferroptosis and cancer prognosis
- Pickering emulsions and particle stabilization
- Inhalation and Respiratory Drug Delivery
- Hydrogels: synthesis, properties, applications
- Click Chemistry and Applications
- Geochemistry and Elemental Analysis
- Organometallic Complex Synthesis and Catalysis
- Blood properties and coagulation
- Electrostatics and Colloid Interactions
- PARP inhibition in cancer therapy
- Ginseng Biological Effects and Applications
- Magnetic Properties and Synthesis of Ferrites
Tianjin University
2024-2025
Zhejiang University
2023-2024
Luoyang Normal University
2024
Southwest Jiaotong University
2021-2023
Stomatology Hospital
2023
Second Affiliated Hospital of Zhejiang University
2019-2022
Northern Jiangsu People's Hospital
2021-2022
Texas A&M University
2017-2022
Australian Regenerative Medicine Institute
2022
Monash University
2022
Although nanomedicines have been pursued for nearly 20 years, fundamental chemical strategies that seek to optimize both the drug and carrier together in a concerted effort remain uncommon yet may be powerful. In this work, two block polymers one dimeric prodrug molecule were designed coassembled into degradable, functional nanocarriers, where chemistry of each component was defined accomplish important tasks. The result is poly(ethylene glycol) (PEG)-protected redox-responsive paclitaxel...
Abstract Active tumor penetration has been recently recognized as a promising strategy to resolve the limitation of nanomedicine in terms penetration, but it is challenging develop active transporting nanocarriers. Here, an ultrasonic cavitation‐assisted and acid‐activatable liposome for broad range tumors reported. The (size charge dual‐conversional gemcitabine prodrug‐integrated liposomal nanodroplet (SCGLN)) overcomes tight blood vessel walls with aid cavitation. SCGLN subsequently...
Abstract The electrochemical reduction of CO 2 into fuels and valuable chemicals represents an appealing approach to alleviate energy crisis global warming. Due its sluggish reaction kinetics the lack suitable electrocatalysts it remains a major challenge. In this work, we report facile synthetic engineer polymeric cobalt phthalocyanine network with rich defects for significantly enhanced electrocatalytic activity reduction. successful defect engineering not only promotes formation stronger...
Fundamental studies that gain an understanding of the tunability physical properties natural product-based polymers are vital for optimizing their performance in extensive applications. Variation glass transition temperature (Tg) was studied as a function side chain structure and molar mass linear poly(glucose carbonate)s. A remarkable range Tg values, from 38 to 125 °C, accomplished with six different alkyloxycarbonyl chains. The impact on investigated two series discrete oligomers...
Sonodynamic therapy (SDT) induces immunogenic cell death (ICD) in tumors and promises to play an assistive role immunotherapy pancreatic cancer. However, the short half-life limited diffusion distance of reactive oxygen species (ROS) impair ICD induction, especially with relatively poor blood perfusion dense stroma.To address this problem, we fabricated cavitation-assisted endoplasmic reticulum (ER) targeted sonodynamic nanodroplets (PMPS NDs, 329 nm). The good effect precise target was...
Abstract As an iron‐dependent, non‐apoptosis, regulated cell death (RCD) modality, ferroptosis has gained growing attention for cancer therapy. With the development of nanomaterials in biomedical field, ferroptotic nanomedicine is extensively investigated. Amongst various nanomaterials, metal‐organic frameworks (MOFs) are hybridized porous materials consisting metal ions or clusters bridged by organic linkers. The superior properties MOFs, such as high porosity and cargo loading, ease...
Mechanical ventilation can induce or aggravate lung injury, which is termed ventilator-induced injury (VILI). Piezo1 a key element of the mechanotransduction process and transduce mechanical signals into biological by mediating Ca2+ influx, in turn regulates cytoskeletal remodeling stress alterations. We hypothesized that it plays an important role occurrence VILI, investigated underlying mechanisms.High tidal volume high magnitude cyclic stretch were performed on Sprague-Dawley rats, A549...
Platelet-like and cylindrical nanostructures from sugar-based polymers are designed to mimic the aspect ratio of bacteria achieve uroepithelial cell binding internalization, thereby improving their potential for local treatment recurrent urinary tract infections. Polymer nanostructures, derived amphiphilic block composed zwitterionic poly(d-glucose carbonate) semicrystalline poly(l-lactide) segments, were constructed with morphologies that could be tuned enhance binding. These nanoparticles...
Click chemistry has increasing applications of the development polymer materials and modification drug carriers. The amino–yne click polymerization reacts quickly at room temperature without catalyst, enamine bond (-ena-) gained from reaction is sensitive to acid can be used prepare stimulus-responsive polymeric prodrugs. Herein, we report an alkynyl-terminated containing alternately distributed low molecular weight polyethylene glycol (PEG) hexamethylenediamino (HMDA) linked by bonds,...
The extent of participation side-chain functionalities during the 1,5,7-triazabicyclo[5.4.0]dec-5-ene (TBD) organobase-catalyzed ring-opening polymerizations (ROP) six-membered cyclic d-glucose-based carbonates was found to result in significantly different regiochemical outcomes. High regioselectivity observed for naturally derived poly(4,6-d-glucose carbonate)s (PGCs) containing carbonate side chain substituents 2- and 3-positions, whereas regioirregularity analogous PGCs with ether...
Inefficient intracellular gene release and transfection limit nonviral delivery applications in cancer therapy. Reactive oxygen species (ROS) responsive is the most widely explored strategy for such applications, yet development of fast safe ROS nanocarriers proves to be a challenge because chemical equilibrium high glutathione levels. Here, we report an ultrasound-enhanced charge-reversal polymeric nanocarrier (BTIL) efficient pancreatic delivery. The BTIL composed B-PDEAEA/DNA...
In this paper, we present a computational reverse-engineering analysis for scattering experiments (CREASE) based on genetic algorithms and molecular simulation to analyze the structure within self-assembled amphiphilic polymer solutions. For given input comprised of intensity profiles information about polymers in solution, CREASE outputs micelles (e.g., core corona diameters, aggregation number) as well conformations chains micelle blocks' radii gyration, chain monomer concentration...
As a rapid, controllable, and easily transferrable approach to the preparation of antimicrobial nanoparticle systems, one-step, light-driven procedure was developed produce asymmetric hybrid inorganic–organic nanoparticles (NPs) directly from homogeneous Ag/polymer mixture. An amphiphilic triblock polymer designed synthesized build biocompatible NPs, consisting poly(ethylene oxide) (PEO), carboxylic acid-functionalized polyphosphoester (PPE), poly(l-lactide) (PLLA). Unexpectedly,...
In this work, we investigated the fundamental molecular parameters that guide supramolecular assembly of glucose-based amphiphilic coil-brush block polymers in aqueous solution and elucidated architecture-morphology relationships through experimental simulation tools. Well-defined were synthesized ring-opening polymerizations (ROP) glucose carbonates to afford norbornenyl-functionalized poly(glucose carbonate) (NB-PGC) macromonomers, followed by sequential metathesis (ROMP) norbornene...
Zwitterionic polymers are a class of that acts as both Lewis base and acid in solution.
Effective delivery of therapeutics to tumors is generally hampered by the limited penetration biological barriers imposed tumor microenvironment. Despite broad applications cell-penetrating peptides (CPPs) for intracellular across membrane bilayers, discovery novel CPPs with enhanced tissue permeability remains largely unexplored. Herein, we identified two short stapled aromatic cross-links that confer superior dual-penetration in cells and tissues over their linear counterparts. This work...
Camptothecin (CPT) is a promising anticancer drug, yet its therapeutic potential has been limited by poor water solubility and facile hydrolysis of the lactone form into an inactive carboxylate at neutral pH. In this work, fundamental synthetic methodology was advanced to allow for preparation well-defined functional polyphosphoramidate (PPA)-based block copolymers that coassembled with CPT nanoparticles, which underwent coincident acid-triggered polymer backbone degradation, nanoparticle...