A5072170620- Neurological diseases and metabolism
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Pain Mechanisms and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Hereditary Neurological Disorders
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Asthma and respiratory diseases
- Noise Effects and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Circular RNAs in diseases
- Urologic and reproductive health conditions
- Dermatology and Skin Diseases
- Vascular Malformations and Hemangiomas
- Eosinophilic Esophagitis
- Cancer-related molecular mechanisms research
- Allergic Rhinitis and Sensitization
- Cancer-related gene regulation
- IL-33, ST2, and ILC Pathways
- Kruppel-like factors research
- Hearing Loss and Rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Tuberous Sclerosis Complex Research
- Parasitic Diseases Research and Treatment
Shanghai Jiao Tong University
2018-2025
Chinese PLA General Hospital
2023-2025
Renji Hospital
2009-2025
Shanghai Cancer Institute
2022-2025
Taiyuan Central Hospital
2024
PLA 306 Hospital
2012-2023
Second Affiliated Hospital of Nanchang University
2017-2023
Huanggang Normal University
2023
Shanghai Children's Hospital
2022-2023
Shanghai Sixth People's Hospital
2017-2023
Switching microglial polarization from the pro-inflammatory M1 phenotype to anti-inflammatory M2 represents a novel therapeutic strategy for neuropathic pain (NP). This study aims investigate whether botulinum toxin type A (BTX-A) regulates M1/M2 by inhibiting P2X7 expression in rat model of NP.The BTX-A administration elevated threshold, induced toward phenotype, and decreased protein level NP chronic compression injury (CCI). Lipopolysaccharide (LPS) was used activate HAPI cells as an...
To explore the clinical characteristics of noise-induced hearing loss (NIHL) caused by long-term exposure to steady-state noise and find a possible inflection point time leading deterioration. Subjects exposed were selected as noise-exposed group matched with control individuals not noise. Both groups underwent pure-tone audiometry (PTA) distortion product otoacoustic emissions (DPOAE), their conditions analyzed. The most significant disparities in NIHL between early late was evaluated....
HCC is one of the most prevalent and deadliest malignancies worldwide, with a poor prognosis. Altered histone modifications have been shown to play significant role in HCC. However, biological roles clinical relevance specific modifications, such as asymmetric dimethylation on arginine 3 H4 (H4R3me2a), remain poorly understood In this study, immunohistochemical staining was performed assess H4R3me2a modification 32 pairs tissues corresponding adjacent nontumor liver tissues. Cellular-level...
Inhibitory response occurs throughout the nervous system, including peripheral olfactory system. While odor-evoked excitation in cells is known to encode odor information, molecular mechanism and functional roles of inhibition remain largely unknown. Here, we examined Drosophila sensory neurons found that inhibitory odors triggered outward receptor currents by reducing constitutive activities odorant receptors, inhibiting basal spike firing neurons. Remarkably, this elicited itself a full...
Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA (miRNA)-based regulation of using an in vitro thrombin toxicity model applied to primary human microglia.A miRNA array identified 22 differential candidates. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) miR-181c the most significantly downregulated miRNA. TargetScan analysis mixed lineage leukemia-1 (MLL1)...
Abstract Background Botulinum toxin type A (BTX-A) was considered to be a new potential drug for neuropathic pain (NP) treatment. Results In vivo, BTX-A attenuated chronic compression injury (CCI)-induced in rats, and reduced production of pro-inflammatory factors. The inhibition expression phosphorylation SNAP23 were partly reversed by TLR2/MyD88 upregulation. LPS-stimulated microglia, we also found that suppressed TLR2, MyD88, p-SNAP23 expression, factors secretion. Upregulation TLR2 MyD88...
Background: The differentiation of microglia from M1 to M2 exerts a pivotal role in the aggression intracerebral hemorrhage (ICH), and long non-coding RNAs (lncRNAs) are associated with microglia. However, underlying mechanism had not been fully clarified. Methods: expression profile lncRNAs thrombin-induced primary was analyzed by RNA sequencing. Under thrombin treatment, effect lncRNA TCONS_00145741 on determined immunofluorescence staining, quantitative real-time PCR, Western blot....
One-third of patients with epilepsy suffer from drug-resistant (DRE). Valproic acid (VPA) is a classic anticonvulsant drug, and its resistance crucial predictor DRE, but the pathogenesis remain unknown. Most VPA-resistant appear distinct inflammatory response local hypoxia. Hypoxia-inducible factor (HIF)-1α an essential effector molecule hypoxia inflammation, may exert therefore significant effect on development epilepsy. We systematically assess significance HIF-1α children mice epilepsy,...
We investigated the mechanisms underlying therapeutic effects of Yiqi Jiemin decoction (YJD), a traditional Chinese medicine (TCM), in ovalbumin (OVA)-induced allergic rhinitis (AR) model guinea pigs. YJD significantly decreased infiltration mast cells and eosinophils into nasal mucosa AR also increased expression TGF-β mucosa, restored balance Th1/Th2 immune cell responses, serum levels various pro-inflammatory mediators, including histamine (HA), neuropeptide Y (NPY), acetylcholine (ACH),...
The connection between m6A-assiociateed lncRNAs and prognosis has been demonstrated in multiple types of tumors. However, potential roles glioma is still rare.We implemented consensus cluster analysis to group the downloaded samples into two subtypes. least absolute shrinkage selection operator (LASSO) was used create a risk model. Additionally, conjunction m6A-related immune cells infiltration explored by conducting R package. Ultimately, we inspected underlying downstream pathways subtypes...
Evaluation of the clinical effect small-volume resuscitation on uncontrolled hemorrhagic shock in emergency Gang Zhao, Wei Wu, Qi-ming Feng, Jian Sun Department Emergency, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, Republic China Objective: The objective present study was to explore resuscitative emergency. Methods: In this study, effects 200 trauma patients with were studied. Half these infused hypertonic/hyperoncotic fluid (small-volume group, n=100),...
Esophageal cancer (EC) is a common malignancy of the digestive tract, with high incidence. The objective this study was to investigate effect miR-630 expression on esophageal cell invasion and migration.The group comprised 58 EC patients admitted our hospital from April 2014 2016, control 60 healthy people visiting during same period. levels in peripheral blood two groups were compared, diagnostic value for analyzed. lines used evaluate influence migration.miR-630 low (p < 0.050). A receiver...
<title>Abstract</title> <bold>Background</bold>: Hypertension, diabetes, and high cholesterol are risk factors for stroke recurrence, referred to as the three highs, their management in patients with cerebral infarction can reduce recurrence death. This study aimed investigate cognition implementation of highs by neurologists tertiary general hospitals Southwest China. <bold>Methods</bold>: A self-designed questionnaire was used evaluate highs. cross-sectional <bold>Results</bold>: Compared...
Abstract: (1) Background: Cancer immune escape is associated with the metabolic reprogramming of TME, and combining targets immunotherapy has great potential to improve clinical outcomes. Among all processes, lipid metabolism, especially fatty acid (FA) a huge role in cancer cell survival, migration, proliferation, but its mechanism tumor microenvironment remain be investigated. (2) Methods: We comprehensively analyzed 309 acid-related genes, screened 121 different used one-way COX...
Neuropathic pain (NP) is one of the most common types chronic and significantly compromises quality life. Autophagy an intracellular catabolic process that required to maintain cellular homeostasis in response various stresses. The role autophagy-related genes diagnosis treatment neuropathic remains unclear.We identified differentially expressed (ARDEGs) miRNAs (DE-miRNAs) by bioinformatics analysis GSE145226 GSE145199 datasets. These ARDEGs their co-expressed were subjected Gene Ontology...