A5043398762- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Tryptophan and brain disorders
- Nanocomposite Films for Food Packaging
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Seaweed-derived Bioactive Compounds
- Studies on Chitinases and Chitosanases
- Computational Drug Discovery Methods
- Geochemistry and Geologic Mapping
- Aluminum toxicity and tolerance in plants and animals
- Vitamin C and Antioxidants Research
- Geological and Geochemical Analysis
- Supramolecular Self-Assembly in Materials
- Nuclear Receptors and Signaling
- Medicinal Plants and Neuroprotection
- Heavy metals in environment
- Proteins in Food Systems
- Trace Elements in Health
- earthquake and tectonic studies
- Arsenic contamination and mitigation
- Biochemical effects in animals
- Flavonoids in Medical Research
- Phytochemicals and Medicinal Plants
Beijing Union University
2015-2025
China Nonferrous Metals Changsha Investigation Design Institute
2024
Gansu Desert Control Research Institute
2014
Chinese Academy of Sciences
2014
Institute of Geology and Geophysics
2014
Lanzhou Veterinary Research Institute
2013
Chinese Academy of Agricultural Sciences
2013
Peking University
2011-2013
Capital Normal University
2006-2007
Zhaotong University
2006
Our present study was conducted to investigate whether liquiritin (7-hydroxy-2-[4-[3,4,5-trihydroxy-6-(hydroxymethyl) oxan-2-yl] oxyphenyl]-chroman-4-one, 1), an active component of Glycyrrhiza uralensis Fisch., exerts a neuroprotective effect against focal cerebral ischemia/reperfusion (I/R) in male Institute Cancer Research (ICR) mice. On the establishment mice with middle artery occlusion (MCAO) for 2 h and reperfusion 22 h, at doses 40, 20, 10 mg/kg administered before MCAO once day...
In recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation impaired performance. The aim this study was to investigate potential effects Morinda officinalis oligosaccharides (MOO) on its symptom, dysfunction. Chronic unpredictable mild stress (CUMS)-induced model constructed, MOO abilities were evaluated. results revealed that able alleviate CUMS-induced depression-like behavior in mice, inhibit...
Alzheimer’s disease (AD) is characterized by a large number of amyloid-β (Aβ) deposits in the brain. Therefore, inhibiting Aβ aggregation or destabilizing preformed aggregates could be promising therapeutic target for halting/slowing progression AD. Chitosan oligosaccharides (COS) have previously been reported to exhibit antioxidant and neuroprotective effects. Recent study shows that COS markedly decrease oligomeric Aβ-induced neurotoxicity oxidative stress rat hippocampal neurons. However,...
Lutein is known to be a nonprovitamin A carotenoid found in broccoli and spinach. The aim of present study was investigate whether lutein can protect brain against ischemic injury by reducing oxidative stress. Male ICR mice were randomly divided into five experimental groups: model group, sham high, middle, low-dose groups (30, 15, 7.5 mg/kg). Mice subjected 2-h middle cerebral artery occlusion followed reperfusion for 22 h. reduced glutathione/oxidized glutathione (GSH/GSSG) ratio,...
This study assessed the modulating effects of liquiritin against cognitive deficits, oxidative damage, and neuronal apoptosis induced by subsequent bilateral intrahippocampal injections aggregated amyloid-β1-42 (Aβ1-42). also explored molecular mechanisms underlying above phenomena. Liquiritin was orally administered to rats with Aβ1-42-induced deficits for 2 weeks. The protective on learning memory impairment Aβ1-42 were examined in vivo using Morris water maze. then euthanized further...
We determined the complete mitochondrial DNA (mtDNA) sequence of a fluke, Paramphistomum cervi (Digenea: Paramphistomidae). This genome (14,014 bp) is slightly larger than that Clonorchis sinensis (13,875 bp), but smaller those other digenean species. The mt P. contains 12 protein-coding genes, 22 transfer RNA 2 ribosomal genes and non-coding regions (NCRs), complement consistent with digeneans. arrangement in identical to digeneans except for group Schistosoma species exhibit derived...
Capripox viruses are economically important pathogens in goat and sheep producing areas of the world, with specific focus on pox virus (GTPV), (SPPV) Lumpy Skin Disease (LSDV). Clinically, have same symptoms cannot be distinguished serologically. This presents a real need for rapid, inexpensive, easy to operate maintain genotyping tool facilitate accurate disease diagnosis surveillance better management outbreaks.A LAMP method was developed differential detection GTPV SPPV using three sets...
Mounting evidence has shown that dyshomeostasis of the redox-active biometals such as Cu and Fe can lead to oxidative stress, which plays a key role in neuropathology Alzheimer' disease (AD). Here we demonstrate with formation Cu(II).beta1-40 complexes, copper markedly potentiates neurotoxicity exhibited by beta-amyloid peptide (Ab). A greater amount hydrogen peroxide was released when complexes added xanthine oxidase/xanthine system detected potassium iodide spectrophotometry. Copper bound...
beta-amyloid peptide (Abeta) is considered to be responsible for the formation of senile plaques, which hallmark Alzheimer's disease (AD). Oxidative stress, manifested by protein oxidation and lipid peroxidation, among other alterations, a characteristic AD brain. A growing body evidence has been presented in support Abeta(1-40) forming an oligomeric complex that binds copper at CuZn superoxide dismutase-like binding site. Abeta(1-40)Cu(II) complexes generate neurotoxic hydrogen peroxide...
Alzheimer's disease (AD) is a neurodegenerative disorder that damages health and welfare of the elderly, there has been no effective therapy for AD until now. It proved tanshinone IIA (tan IIA) could alleviate pathological symptoms via improving non-amyloidogenic cleavage amyloid precursor protein, decreasing accumulations p-tau amyloid-β1-42 (Aβ1-42), so forth. However, further biochemical mechanisms tan are not clear. The experiment was undertaken to explore metabolites in rats induced by...
Background The rationale for the pathogenesis of Alzheimer’s disease (AD) is production amyloid-beta (Aβ) and its resultant toxic effects. Purpose In this work, rats with AD were used as models to assess modulatory effects tanshinone IIA (tan IIA) in alleviating cognitive impairment, oxidative damage, inflammation apoptosis. Materials Methods Aβ 1–42 was injected bilaterally hippocampus establish an rat model. tan II A on learning memory capacities detected by ethological experiments. Tan...
The Baoshan Cu-Pb-Zn deposit is situated at the intersection of Qin-Hang Cu polymetallic and Nanling W-Sn metallogenic belts. age, lithology, petrogenesis, tectonic setting granodiorite porphyry within remain subjects debate. Additionally, there a lack comparative studies with W-Sn-related granites in region. This study conducted whole-rock major trace element analysis, Sr-Nd isotope zircon U-Pb dating on porphyry. age 162 ± 1 Ma. SiO2 K2O contents range from 65.87 to 68.21 wt.% 3.42 5.62...
Abstract Background Brain amyloid deposition is one of the main pathological characteristics Alzheimer’s disease (AD). Soluble oligomers formed during process that causes β-amyloid (Aβ) to aggregate into plaques are considered have major neurotoxicity. Currently, drug development for treatment has encountered serious difficulties. Our newly proposed solution accelerate aggregation Aβ reduce amount cytotoxic in brain tissue. This strategy differs from existing reducing total content and...