A5017173574- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Congenital Anomalies and Fetal Surgery
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Toxoplasma gondii Research Studies
- Cell Adhesion Molecules Research
- Helminth infection and control
- Trace Elements in Health
- RNA modifications and cancer
- Animal Disease Management and Epidemiology
- Immune Response and Inflammation
- Insect-Plant Interactions and Control
- Invertebrate Taxonomy and Ecology
- Identification and Quantification in Food
- Herpesvirus Infections and Treatments
- Hepatitis C virus research
- Poxvirus research and outbreaks
- Chromosomal and Genetic Variations
- Genetics, Bioinformatics, and Biomedical Research
- Viral Infections and Immunology Research
- Hepatitis B Virus Studies
- Cancer Research and Treatments
Chinese Academy of Agricultural Sciences
2013-2025
Lanzhou University
2006-2025
Lanzhou Veterinary Research Institute
2014-2025
Jilin University
2014-2018
Institute of Parasitology
2013
Lanzhou City University
2013
Codon usage bias is an important evolutionary feature in a genome and has been widely documented many genomes. Analysis of codon significance for mRNA translation, design transgenes, new gene discovery, studies molecular biology evolution, etc. However, the information about synonymous pattern T. saginata remains unclear. food-borne zoonotic cestode which infects approximataely 50 million humans worldwide, causes significant health problems to host considerable socio-economic losses as...
Abstract Taenia saginata, solium and asiatica (beef, pork Asian tapeworms, respectively) are parasitic flatworms of major public health food safety importance. Among them, T. is a newly recognized species that split from saginata via an intermediate host switch ∼1.14 Myr ago. Here we report the 169- 168-Mb draft genomes . Comparative analysis reveals high rates gene duplications functional diversifications might have partially driven divergence between We observe accelerated evolutionary...
Coenurosis, caused by the larval coenurus of tapeworm Taenia multiceps, is a fatal central nervous system disease in both sheep and humans. Though treatment prevention options are available, control coenurosis still faces presents great challenges. Here, we present high-quality genome sequence T. multiceps which 240 Mb (96%) has been successfully assembled using Pacbio single-molecule real-time (SMRT) Hi-C data with N50 length 44.8 Mb. In total, 49.5 (20.6%) repeat sequences 13, 013 gene...
ABSTRACT Cystic echinococcosis (CE), caused by Echinococcus granulosus sensu stricto ( s.s. ), poses a substantial risk to both humans and domestic animals globally. Here, we compared the whole genomes of 111 E. samples from China. Genomic variation data revealed frequent cross-fertilization in hermaphroditic . The G1 G3 genotypes represent distinct mitochondrial lineages, while showing no differentiation nuclear genome, suggesting mito-nuclear discordance historical geographic separation...
We determined the complete mitochondrial DNA (mtDNA) sequence of a fluke, Paramphistomum cervi (Digenea: Paramphistomidae). This genome (14,014 bp) is slightly larger than that Clonorchis sinensis (13,875 bp), but smaller those other digenean species. The mt P. contains 12 protein-coding genes, 22 transfer RNA 2 ribosomal genes and non-coding regions (NCRs), complement consistent with digeneans. arrangement in identical to digeneans except for group Schistosoma species exhibit derived...
The cestode Echinococcus multilocularis is the causative agent of human alveolar echinococcosis (AE). However, this life-threatening disease still difficult to treat and control, due lack efficient drugs vaccines. Excretory/secretory (ES) proteins are crucial for parasite survival represent potential preferred targets novel intervention strategies. ES protein features in have been poorly investigated until now. current study was carried out identify characterise a repertoire E. at...
Alveolar echinococcosis (AE), which is caused by larval Echinococcus multilocularis, one of the world's most dangerous neglected diseases. Currently, no fully effective treatments are available to cure this disease.In vitro protoscolicidal assay along with in vivo murine models was applied repurposing drugs against AE. Genome-wide identification and homology-based modeling were used for predicting drug targets. RNAi, enzyme assay, RNA-Seq analyses utilized investigating roles parasite...
Tissue-dwelling helminths affect billions of people around the world. They are potent manipulators host immune system, prominently by promoting regulatory T cells (Tregs) and generally associated with a modified gut microbiome. However, role microbiota in immunomodulatory processes for these non-intestinal parasites is still unclear. In present study, we used an extra-intestinal cestode helminth model-larval Echinococcus multilocularis to explore tripartite partnership...
As the linker between A chain and B of proinsulin, C-peptide displays high variability in length amino acid composition, has been considered as an inert byproduct insulin synthesis processing for many years. Recent studies have suggested that can act a bioactive hormone, exerting various biological effects on pathophysiology treatment diabetes. In this study, we analyzed coevolution molecules among vertebrates, aiming at exploring evolutionary characteristics molecule, especially C-peptide....
The tapeworm Taenia solium is an important human zoonotic parasite that causes great economic loss and also endangers public health. At present, effective vaccine will prevent infection chemotherapy without any side effect remains to be developed. In this study, codon usage patterns in the T. genome were examined through 8,484 protein-coding genes. Neutrality analysis showed had a narrow GC distribution, significant correlation was observed between GC12 GC3. Examination of NC (ENC vs...
Gene duplication (GD), thought to facilitate evolutionary innovation and adaptation, has been studied in many phylogenetic lineages. However, it remains poorly investigated trematodes, a medically important parasite group that evolutionarily specialized during long-term host-parasite interaction. In this study, we conducted genome-wide study of GD modes contributions S. mansoni, pathogen causing human schistosomiasis. We combined several lines evidence provided by duplicate age...
Cysticercosis remains a major neglected tropical disease of humanity in many regions, especially sub-Saharan Africa, Central America and elsewhere. Owing to the emerging drug resistance inability current drugs prevent re-infection, identification novel vaccines chemotherapeutic agents against Taenia solium related helminth pathogens is public health priority. The T. genome predicted proteome were reported recently, providing wealth information from which new interventional targets might be...
Wnt proteins are a family of secreted glycoproteins that evolutionarily conserved and considered to be involved in extensive developmental processes metazoan organisms. The characterization wnt genes may improve understanding the parasite's development. In present study, wnt4 gene encoding 491amino acids was amplified from cDNA metacestodes Taenia solium using reverse transcription PCR (RT-PCR). Bioinformatics tools were used for sequence analysis. domain predicted. expression profile Wnt4...
Besides the complete genome, different partial genomic sequences of Hepatitis E virus (HEV) have been used in genotyping studies, making it difficult to compare results based on them. No commonly agreed region for HEV has determined. In this study, we a statistical method evaluate phylogenetic performance each sequence from genome wide, by comparisons evolutionary distances between regions and full-length genomes 101 isolates identify short that can reproduce genotype assignments genomes....
We report here a human case of Taenia asiatica infection which was confirmed by genetic analyses in Dali, China. A patient found to have symptoms taeniasis with discharge tapeworm proglottids. By sequencing the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene, we observed nucleotide sequence identity 99% T. and 96% saginata. Using b (cytb) saginata were found. Our findings suggest that people China may be mainly caused asiatica. Key words: asiatica, report, cox1 cytb gene
Taenia hydatigena is a widespread gastrointestinal helminth that causes significant health problems in livestock industry. This parasite can survive remarkably wide range of intermediate hosts and affects the transmission dynamics zoonotic parasites. T. therefore particular interest to researchers interested studying diseases evolutionary strategies Herein we report high-quality draft genome for this tapeworm, characterized by some hallmarks (e.g., expanded size, integrations viral-like...