A5066860889- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
- Epilepsy research and treatment
- Chronic Kidney Disease and Diabetes
- Wnt/β-catenin signaling in development and cancer
- Renal and related cancers
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Reproductive System and Pregnancy
- Genetic and Kidney Cyst Diseases
- Neuroscience and Neuropharmacology Research
- Diabetes and associated disorders
- Cholesterol and Lipid Metabolism
- Biomedical Research and Pathophysiology
- Neurological disorders and treatments
- Cancer Research and Treatments
- melanin and skin pigmentation
- Atherosclerosis and Cardiovascular Diseases
- Regulation of Appetite and Obesity
- Tuberous Sclerosis Complex Research
- Antifungal resistance and susceptibility
- NF-κB Signaling Pathways
- Genomics, phytochemicals, and oxidative stress
- Lung Cancer Treatments and Mutations
University of Toledo
2018-2025
Ruijin Hospital
2007-2025
Shanghai Jiao Tong University
2008-2025
Second Xiangya Hospital of Central South University
2021-2025
Central South University
2011-2025
Jiangsu University
2024-2025
Affiliated Hospital of Jiangsu University
2024-2025
University of Florida
2000-2024
Xuzhou Medical College
2024
Nanjing University of Posts and Telecommunications
2023
Research reveals the structure of TRPC5 ion channel, a potential drug target kidney disease, depression and anxiety.
Transition of acute kidney injury (AKI) to chronic disease (CKD) represents an important cause failure. However, how AKI is transformed into CKD remains elusive. Following folic acid injury, mice developed with ensuing transition, featured by variable degrees interstitial fibrosis and tubular cell atrophy growth arrest. This lingering renal tubules was associated sustained oxidative stress that concomitant impaired Nrf2 antioxidant defense, marked mitigated nuclear accumulation blunted...
As life expectancy continues to increase, clinicians are challenged by age-related renal impairment that involves podocyte senescence and glomerulosclerosis. There is now compelling evidence lithium has a potent antiaging activity ameliorates brain aging increases longevity in Drosophila Caenorhabditis elegans. the major molecular target of action multitasking protein kinase recently implicated variety diseases, glycogen synthase 3β (GSK3β) overexpressed hyperactive with age glomerular...
Emerging evidence suggests that GSK3β, a redox-sensitive transducer downstream of insulin signaling, acts as convergent point for myriad pathways implicated in kidney injury, repair, and regeneration. However, its role diabetic disease remains controversial. In cultured glomerular podocytes, exposure to milieu type 2 diabetes elicited prominent signs podocyte injury degeneration, marked by loss homeostatic marker proteins like synaptopodin, actin cytoskeleton disruption, oxidative stress...
Evidence suggests that glycogen synthase kinase 3β (GSK3β) contributes to AKI; however, its role in post-AKI kidney repair remains uncertain. Here, delayed treatment with a single dose of lithium, selective inhibitor GSK3β and US Food Drug Administration-approved mood stabilizer, accelerated recovery renal function, promoted repopulation tubular epithelia, improved murine models cisplatin- ischemia/reperfusion-induced AKI. These effects associated reduced activity elevated expression...
Impaired adaptive response to oxidative injuries is a fundamental mechanism central the pathogenesis of chronic hepatitis C (CHC). Glycogen synthase kinase (GSK) 3β an indispensable regulator stress response. However, exact role GSK3β in CHC uncertain and was examined.GSK3β Nrf2 signalling pathways were examined JFH1 HCV infected Huh7.5.1 hepatocytes, also liver biopsy specimens from patients.HCV infection elicited prominent antioxidant marked by elevated expression Nrf2-dependent molecule...
Evidence suggests that the glycogen synthase kinase 3 (GSK3)–dictated nuclear exclusion and degradation of Nrf2 is pivotal in switching off self-protective antioxidant stress response after injury. Here, we examined mechanisms underlying this regulation glomerular disease. In primary podocytes, doxorubicin elicited cell death actin cytoskeleton disorganization, concomitant with overactivation GSK3 β (the predominant isoform expressed podocytes) minimal activation. SB216763, a highly...
Activation of NFkappaB is a fundamental cellular event central to all inflammatory diseases. Hepatocyte growth factor (HGF) ameliorates both acute and chronic inflammation in multitude organ systems through modulating activity; nevertheless, the exact molecular mechanism remains uncertain. Here we report that HGF inactivation GSK3beta suppresses p65 phosphorylation specifically at position Ser-468. The Ser-468 RelA/p65 situates consensus motif could be directly phosphorylated by vivo vitro,...
Aberrant focal adhesion turnover is centrally involved in podocyte actin cytoskeleton disorganization and foot process effacement. The structural dynamic integrity of adhesions orchestrated by multiple cell signaling molecules, including glycogen synthase kinase 3β (GSK3β), a multitasking lately identified as mediator kidney injury. However, the role GSK3β podocytopathy remains obscure. In doxorubicin (Adriamycin)-injured podocytes, lithium, inhibitor neuroprotective mood stabilizer,...
Although over 40 type 1 diabetes (T1D) risk loci have been mapped in humans, the causative genes and variants for T1D are largely unknown. Here, we investigated a candidate gene 21q22.3 locus-UBASH3A, which is primarily expressed T cells where it thought to play redundant role. Genetic UBASH3A shown be associated with several autoimmune diseases addition T1D. However, molecular mechanism underlying these genetic associations unresolved. Our study reveals previously unrecognized role of human...
Converging evidence points to glycogen synthase kinase (GSK) 3 as a key player in the pathogenesis of podocytopathy and proteinuria. However, it remains unclear if GSK3 is involved podocyte autonomous injury glomerular disease. In normal kidneys, β isoform was found be major expressed glomeruli intensely stained podocytes. GSK3β expression podocytes markedly elevated experimental or human proteinuric glomerulopathy. Podocyte-specific somatic ablation adult mice attenuated proteinuria...
Burgeoning evidence points to glycogen synthase kinase (GSK)3β as a key player in diverse kidney diseases. However, pivotal transducer of the insulin signaling pathway, role GSK3β diabetic disease remains uncertain. In db/db mice, renal expression total and activated was increasingly elevated. This preceded development disease, correlated with progression signs injury, including albuminuria extracellular matrix accumulation glomeruli tubulointerstitia. vitro, exposure glomerular podocytes,...
The triglyceride-glucose (TyG) index has emerged as a validated and cost-effective indicator of insulin resistance (IR). Given the significant association between visceral obesity IR, this study aimed to investigate utility TyG in estimating patients with gastric cancer (GC). fat area (VFA), subcutaneous (SFA), VFA-to-SFA ratio (VSR) were determined through analysis CT images at lumbar 3 level. definition was established VFA ≥ 100 cm2. assessed using logistic regression restricted cubic...
<p dir="ltr">Genome-wide association studies have identified <i>SH2B3 </i>as an important non-MHC gene for islet autoimmunity and type 1 diabetes (T1D). In this study, we found a single <i>SH2B3</i> haplotype significantly associated with increased risk human T1D. Fine mapping has demonstrated the most credible causative variant is nucleotide rs3184504*T polymorphism in <i>SH2B3</i><i>.</i> To better characterize role of SH2B3 T1D, used...
<p dir="ltr">Genome-wide association studies have identified <i>SH2B3 </i>as an important non-MHC gene for islet autoimmunity and type 1 diabetes (T1D). In this study, we found a single <i>SH2B3</i> haplotype significantly associated with increased risk human T1D. Fine mapping has demonstrated the most credible causative variant is nucleotide rs3184504*T polymorphism in <i>SH2B3</i><i>.</i> To better characterize role of SH2B3 T1D, used...
This study aimed to explore the importance of routine coagulation tests for early detection sepsis and quickly identify patients at a high risk mortality. retrospective single-center collected data from meeting clinical criteria systemic inflammatory response syndrome (SIRS) with confirmed infection source. Patients disorders or on medications affecting were excluded. divided into non-sepsis groups based Sequential Organ Failure Assessment (SOFA) score ≥2. Univariate multivariate logistic...