A5101419031- Heme Oxygenase-1 and Carbon Monoxide
- Acute Ischemic Stroke Management
- Congenital Heart Disease Studies
- Renal Diseases and Glomerulopathies
- Cardiac Structural Anomalies and Repair
- Cancer-related molecular mechanisms research
- Venous Thromboembolism Diagnosis and Management
- RNA modifications and cancer
- Stroke Rehabilitation and Recovery
- Cardiac Valve Diseases and Treatments
- Autophagy in Disease and Therapy
- Anatomy and Medical Technology
- Inflammasome and immune disorders
- Glioma Diagnosis and Treatment
- Surgical Simulation and Training
- Cancer-related gene regulation
- Lipid metabolism and disorders
- MRI in cancer diagnosis
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Sepsis Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Gout, Hyperuricemia, Uric Acid
- Advanced Glycation End Products research
First Affiliated Hospital of Zhengzhou University
2014-2025
Henan Provincial Center for Disease Control and Prevention
2021-2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
First People's Hospital of Foshan
2023-2024
Zhengzhou University
2014-2023
First Affiliated Hospital Zhejiang University
2023
Kelun Group (China)
2023
National Clinical Research Center for Digestive Diseases
2021
Zhengzhou Children's Hospital
2019
In fully-automatic radiomics model for predicting overall survival (OS) of glioblastoma multiforme (GBM) patients, the effect image standardization parameters such as voxel size, quantization method and gray level on reproducibility prognostic performance are still unclear. this study, 45792 multiregional features were automatically extracted from multi-modality MR images with different sizes, methods, levels. The feature assessed. Multiparametric fixed-parameter signatures constructed based...
Evidence suggests that the glycogen synthase kinase 3 (GSK3)–dictated nuclear exclusion and degradation of Nrf2 is pivotal in switching off self-protective antioxidant stress response after injury. Here, we examined mechanisms underlying this regulation glomerular disease. In primary podocytes, doxorubicin elicited cell death actin cytoskeleton disorganization, concomitant with overactivation GSK3 β (the predominant isoform expressed podocytes) minimal activation. SB216763, a highly...
Objective To assess the clinical value of three-dimensional (3D) printing technology for treatment strategies complex double outlet right ventricle (DORV). Methods Twenty-five patients with were enrolled in this study. The divided into two groups: 3D group (eight patients) and a non-3-D control (17 patients). cardiac images transformed to Digital Imaging Communications segmented reconstructed create heart model. No models created group. A Pearson coefficient analysis was used correlation...
Abstract Background LncRNA AK044604 (regulator of insulin sensitivity and autophagy, Risa ) autophagy-related factors Sirt1 GSK3β play important roles in diabetic nephropathy (DN). In this study, we sought to explore the effect on Sirt1/GSK3β-induced podocyte injury. Methods Diabetic db/db mice received -inhibition adeno-associated virus (AAV) via tail vein injection, intraperitoneal injection lithium chloride (LiCl). Blood, urine, kidney tissue samples were collected analyzed at different...
Acute kidney injury (AKI) involves a series of syndromes characterized by rapid increase in creatinine levels. Ferroptosis, as an iron-dependent mode programmed cell death, reportedly participates the pathogenesis AKI. Methyltransferase-like 3 (METTL3)-mediated m6A modification has been recently associated with various diseases; however, mechanism METTL3 crosstalk molecules involved ferroptosis is not clearly understood. Here, we investigated between METTL3-mediated and was elevated patients...
Acute kidney injury (AKI) lacks a definitive therapeutic approach beyond supportive care. One significant pathological mechanism involves the regulated death of tubular epithelial cells; however, regulatory mechanisms underlying this cell pathway require further investigation. The N6-methyladenosine (m6A) modification, recognized as most prevalent modification in eukaryotes, plays critical role processes associated with AKI. Here, study investigates association between methyltransferase-like...
Background and purpose Stroke is a leading cause of morbidity mortality worldwide. Endovascular therapy (EVT) has been established as gold standard option to treat acute ischemic stroke (AIS) patients with large vessel occlusion (LVO) presenting within 6 h symptom onset. However, there paucity information regarding patient outcome in late time window 24 h. In this study, we aimed assess for predictors outcomes following EVT. Methods We analyzed data from 202 treated EVT four comprehensive...
Background: Epithelial-mesenchymal transition (EMT) is recognized to play an important role in diabetic nephropathy (DN). Objective: To analyze the roles of glycogen synthase kinase 3β (GSK-3β), β-catenin and Snail signaling high glucose (HG)-induced mouse podocytes EMT. Methods: Differentiated were divided into: normal group (NG: 5.6mM), HG groups (12.5HG: 12.5mM; 25HG: 25mM; 50HG: 50mM glucose), osmotic control (NG+M: 5.6mM mannitol 44.4mM). GSK-3β, assessed using semi-quantitative RT-PCR,...
N6-Methyladenosine (m6A) refers to the methylation modification occurring at nitrogen-6 position of adenosine. Many human physiological processes such as modulation spermatogenesis are caused by m6A RNA modifications. However, relationship between regulators and kidney renal clear cell carcinoma (KIRC) remains rarely investigated. This work aimed explore influence in KIRC. We examined abnormally expressed among different clinicopathological features recognized three subgroups (KIRC1, KIRC2,...
Diabetic nephropathy is a lethal disease that can lead to chronic kidney and end-stage disease. Exosomes, which are nanosized extracellular vesicles, closely involved in intercellular communication. Most importantly, exosomes play critical roles occurrence development. However, the function of diabetic progression has not been fully elucidated. In present study, we determined expression profiles differences lncRNAs, mRNAs, circRNAs miRNAs derived from human renal tubular epithelial cells...
Reaction diffusion is the most common growth modelling methodology due to its simplicity and consistency with biological tumor process. However, current extensions of reaction model lack one or more following: efficient inclusion treatments' effects, taking into account viscoelasticity brain tissues, guaranteed stability numerical solution. We propose a new overcome aforementioned drawbacks. Guided by directional information derived from tensor imaging, our relates tissue heterogeneity...
Phakic intraocular lenses (pIOLs), particularly posterior chamber pIOLs, are becoming important for patients with high myopia and thin corneas. By phakic intraocular, we mean the ocular environmental conditions, where natural lens is unremoved. A new pIOL, sine wave refractive (SW-PRL), in development stage, its aqueous humor (AH) dynamics effects of geometry on flow characteristics not well understood. To analyze adaptability functionality SW-PRL, a comparison study made counterparts,...
Background Right internal jugular vein (IJV) is a preferred access route for tunneled (cuffed) dialysis catheters (TDCs), and both right external (EJV) left IJV are alternative routes patients in case the isn't available TDC placement. This retrospective study aimed to determine if disparity exists between two hemodialysis terms of outcomes TDCs. Methods 49 who required TDCs through EJV (n = 21) or 28) as long-term vascular were included this study. The primary end point was cumulative...
Abstract Albuminuria is a hallmark of diabetic nephropathy (DN). Podocyte injury significantly contributes to proteinuria in DN. Our study found that lncRNA EVF‐2 upregulated podocytes DN patients, correlating with cell cycle re‐entry and inflammation. Specific knockout or knockdown evf‐2 mice cultured alleviated podocyte associated these processes. RNA sequencing evf‐2‐overexpressing unveiled predominant enrichment mRNAs inflammation pathways, alternative splicing cycle‐related Ccnb1 Tacc3....
This study sought to evaluate the feasibility, safety, and efficacy of perventricular device closure a doubly committed sub-arterial ventricular septal defect (dcVSD) through left infra-axillary approach.Forty-five patients, with dcVSD less than 8 mm in diameter, were enrolled this study. The pericardium was exposed opened mini-incision. Two parallel purse-string sutures placed on right ventricle outflow tract under transesophageal echocardiography guidance, delivery sheath loaded inserted...
Introduction: Endovascular thrombectomy (EVT) is the standard of care for patients with large-vessel occlusion acute ischemic stroke (AIS). There may be differing recanalization effectiveness based on patients’ sex, and understanding such variations can improve patient outcomes by adjusting differences. We aimed to assess sex differences in outcome after EVT AIS. Methods: retrospectively analyzed 250 consecutive AIS who underwent from July 2019 February 2022 across two large comprehensive...
New Findings What is the central question of this study? Activation glycogen synthase kinase 3 β (GSK‐3β)–hypoxia‐inducible factor 1 α (HIF‐1α) pathway results in stimulation pyroptosis under high glucose, and exerts actions a number renal diseases: does have role tubular epithelial cells? main finding its importance? Down‐regulation GSK‐3β can inhibit cells induced by glucose may be related to down‐regulation HIF‐1α. This GSK‐3β–HIF‐1α has not previously been reported identifies potential...
Objective This study reports the results of a steerable delivery system under guidance transesophageal echocardiography (TEE) for treatment transjugular closure secundum atrial septal defects (ASD). Methods From July 2015 to May 2016, 33 patients underwent ASD general anesthesia with TEE guidance. The right internal jugular vein was punctured and FuStar™ sheath implanted into atrium aligned vertically septum, device deployed close defect. Results Thirty-two an were successfully occluded; one...
Ecdysteroids are steroidal insect molting hormones that also exist in herbs. Ecdysteroid-containing adaptogens have been popularly used to improve well-being and by bodybuilders for muscle growth. However, the use of ecdysone mammals is associated with kidney growth enlargement, indications disturbed homeostasis. The underlying pathogenic mechanism remains be clarified. Virtual screening tools were employed identify compounds homologous predict putative ecdysone-interacting proteins. effect...
// Pei Wang 1,2 , Sijie Zhou Yan Ge 2 Minglei Lu Zhangsuo Liu 1 and Rujun Gong Institute of Nephrology, Blood Purification Center, the First Affiliated Hospital Zhengzhou University, Zhengzhou, China Department Medicine, Division Kidney Disease Hypertension, Brown University School Providence, Rhode Island, USA Correspondence to: Liu, email: Gong, Keywords : glomerulus, podocyte, immune phenotype, proteinuria, NFkB, Pathology Section Received July 02, 2017 Accepted 26, Published August 03,...
Background: Perimembranous ventricular septal defect (pmVSD) is a common congenital heart disease. Transaxillary occluder device closure of the pmVSD has been proved effective and an alternative to surgical closure. The study aimed evaluate immediate operation outcomes early midterm follow-up transaxillary Methods: From January 2014 December 2017, we retrospectively analyzed patients who underwent pmVSD. All transthoracic echocardiography (TTE), chest x-ray, electrocardiogram (ECG) before...
Objective: This cross-sectional investigation aimed to determine the incidence, clinical characteristics, prognosis, and related risk factors of olfactory gustatory dysfunctions infection with SARS-CoV-2 Omicron strain in mainland China. Methods: Data patients from December 28, 2022, February 21, 2023, were collected through online offline questionnaires 45 tertiary hospitals one center for disease control prevention The questionnaire included demographic information, previous health...
Diabetic kidney disease (DKD) is a renal microvascular caused by hyperglycemia that involves metabolic remodeling, oxidative stress, inflammation, and other factors. The mechanism complex not fully unraveled. We performed an integrated single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq) RNA-sequencing (scRNA-seq) analyses of kidneys from db/db db/m mice to identify differential open regions gene expression, particularly in genes related proximal tubular...