A5101541522- Renal cell carcinoma treatment
- Bone health and osteoporosis research
- Renal and related cancers
- Mesenchymal stem cell research
- Bone Metabolism and Diseases
- Urinary Tract Infections Management
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac Ischemia and Reperfusion
- Venous Thromboembolism Diagnosis and Management
- RNA modifications and cancer
- Hip and Femur Fractures
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Urinary Bladder and Prostate Research
- Tissue Engineering and Regenerative Medicine
- Cancer, Lipids, and Metabolism
- EEG and Brain-Computer Interfaces
- Bone and Joint Diseases
- Cardiac Fibrosis and Remodeling
- Plant Molecular Biology Research
- Cardiac Imaging and Diagnostics
- Cancer-related molecular mechanisms research
- Biomarkers in Disease Mechanisms
- Lung Cancer Treatments and Mutations
- Prostate Cancer Diagnosis and Treatment
Hainan Normal University
2021-2025
Peking University
2014-2025
Peking University Cancer Hospital
2014-2025
University of Electronic Science and Technology of China
2023-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023-2024
Hubei University of Medicine
2024
Taihe Hospital
2024
Peking University Shougang Hospital
2023-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
The use of adult stem cells is limited by the quality and quantity host cells. It has been demonstrated that Wharton's jelly–derived mesenchymal (WJMSCs), a primitive stromal population, could integrate into ischemic cardiac tissues significantly improve heart function. In this randomized, controlled trial, our aim was to assess safety efficacy intracoronary WJMSCs in patients with ST-elevation acute myocardial infarction (AMI). multicenter 116 MI were randomly assigned receive an infusion...
Abstract Objective Our aim was to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). Methods In this randomized, single-blind, controlled trial, STEMI (aged 39–76 years) were enrolled at 6 centers Beijing (The People’s Liberation Army Navy General Hospital, Armed Police Chinese Huaxin Tongren Chaoyang Hospital West Hospital). All underwent optimum medical...
Purpose To evaluate the diagnostic values of systemic immune-inflammation index (SII) and neutrophil–lymphocyte ratio (NLR) in patients with localized prostate cancer (PCa). Methods Between January 2014 December 2019, 117 benign hyperplasia (BPH) 278 PCa who underwent radical prostatectomy (RP) were included this study. The inflammatory markers including SII, NLR, platelet–lymphocyte (PLR), lymphocyte–monocyte (LMR), lymphocyte (LR), neutrophil (NR), mean platelet volume (MPV), red cell...
Albizia odoratissima (L. f.) Benth. is a highly valuable tree species, both economically and ecologically. It has great potential for development. To conserve, develop, use its genetic resources sustainably, it crucial to evaluate the habitat of A. identify key environmental factors that affect distribution. In this study, Biomod2 model was used predict distribution in China, using 65 occurrence points 11 variables current future climate scenarios. The mainly influenced by three...
Clear cell renal carcinoma (ccRCC) is a prevalent urogenital malignancy characterized by heterogeneous patterns. Stemness pivotal factor in tumor progression, recurrence, and metastasis. Nevertheless, the impact of stemness-related long non-coding RNAs (SRlncRNAs) on prognosis ccRCC remains elusive. In this study, we aimed to delve into SRlncRNAs develop signature for risk stratification prediction. Gene-expression clinical data were downloaded from The Cancer Genome Atlas (TCGA) Gene...
Uveal melanoma is an aggressive cancer which has a high percentage metastasizing to the liver, with worse prognosis. Identification of patients at risk metastases may provide information for early detection and treatment.Expression profiling ocular tumor tissues from 46 liver metastatic uveal samples 45 non-metastatic were got GEO database. Bioinformatic analyses such as Gene Oncology Kyoto Encyclopedia Genes Genomes used identify genes pathways specifically associated melanoma.A total 1138...
Purpose: To validate the efficacies of three screening tools including Osteoporosis Self-Assessment Tool for Asians (OSTA), Fracture Risk Assessment (FRAX) without bone mineral density (BMD), and body mass index (BMI) predicting postmenopausal osteoporosis (OP) to define ideal thresholds avoidance dual-energy X-ray absorptiometry (DXA) scanning in a Han Chinese population Beijing. Patients Methods: A total 2055 community-dwelling Beijing females aged ≥ 45 years were enrolled this study. All...
To investigate the association between preoperative systemic immune-inflammation index (SII) and neutrophil-lymphocyte ratio (NLR) oncological outcomes in localized prostate cancer (PCa) patients after radical prostatectomy (RP).Between January 2014 December 2019, 291 with pathologically confirmed PCa who underwent RP were included this study. The threshold values of SII NLR for biochemical recurrence (BCR) calculated according to Youden's based on receiver operating characteristic (ROC)...
China ranks the first worldwide in number of new colorectal cancer (CRC) cases and CRC-related deaths. The increasing incidence early-onset CRC recent years highlights challenges related to screening prevention. High-quality colonoscopy is universally used gold standard for screening. Risk assessment combined with a two-step strategy based on non-invasive examinations was proven be highly effective. However, systematic use well-established risk factors associated CRC, beyond age, could...
Mucinous adenocarcinoma (MAC) is a unique subtype of colorectal cancer and its prognostic value remains controversial. This study aimed to compare the clinicopathological characteristics differences between patients with MAC non-mucinous (NMAC). 674 NMAC, 110 mucinous component (ACWM) 77 2016-2019 were enrolled in study. Univariate multivariate Cox regression performed analyze factors associated prognosis. Predictive nomograms overall survival (OS) cancer-specific (CSS) for constructed....
Introduction: Renal cell carcinoma (RCC) is a common type of kidney cancer with limited treatment options and high mortality rate. Therefore, it essential to understand the role mechanism key genes in RCC development progression. This study aimed analyze zinc fingers homeoboxes 2 (ZHX2) underlying mechanism. Methods: RNA expression was analyzed by quantitative real-time polymerase chain reaction, while protein Western blotting assay immunohistochemistry assay. Cell viability evaluated using...
In this cross-sectional study, three clinical tools, the Osteoporosis Self-Assessment Tool for Asians (OSTA), Fracture Risk Assessment (FRAX) without bone mineral density (BMD), and body mass index (BMI), predicting primary osteoporosis (OP) were compared ideal thresholds omission of screening BMD proposed in a community-dwelling elderly Han Beijing male population.A total 1,349 males aged ≥50 years enrolled study. All subjects completed questionnaire measured by dual-energy X-ray...
// Baoan Hong 1 , Yong Yang 2 Sheng Guo 3 Shayiremu Duoerkun 4 Xiaohu Deng 5 Dawei Chen Shijun Yu Wubin Qian Qixiang Li Qing 6 Kan Gong and Ning Zhang Department of Urology, Peking University First Hospital, Institute University, Beijing, P.R. China Beijing Cancer for Research, Division Translational Oncology, Crown Bioscience, Taicang, Jiangsu, Central Hospital HaMi Region, Xinjiang, People's Kelamayi, Center Cellular & Structural Biology, School Pharmaceutical Sciences, Sun Yat-Sen...
Melon is a popular fruit vegetable crop worldwide with diverse morphological variation. We report high-density genetic map of melon and nine major QTLs physical region ranging from 43.47 kb to 1.89 Mb. Importantly, two seed-related trait were repeatedly detected in environments, the mapping was narrowed 522 according regional linkage analysis. A total 40 annotated genes screened for nonsynonymous variations, which EVM0009818, involved cytokinin-activated signaling, differentially expressed...
Peptidyl arginine deiminase, type IV (PADI4) plays an important role in inflammation and the immune response, it has been shown to be associated with rheumatoid arthritis, osteoarthritis ankylosing spondylitis (AS). However, little is known about precise of PADI4 pathogenic process vitro. In this study, we aimed investigate expression synovial tissue patients AS determine potential effects on human mesenchymal stem cell (hMSC) proliferation osteogenic differentiation under normal...
To investigate the role of inflammatory factors including systemic immune-inflammation index (SII) and neutrophil to lymphocyte ratio (NLR) in predicting Gleason Score (GS) upgrading (GSU) localized prostate cancer (PCa) after radical prostatectomy (RP).The data 297 patients who underwent biopsy RP our center from January 2014 March 2020 were retrospectively analyzed. Preoperative clinical characteristics age, values tPSA, total volume (TPV), f/t PSA ratio, body mass (BMI), GS SII, NLR,...
Background: Lung cancer is a heterogeneous disease with severe burden. Because the prognosis of patients lung varies, it critical to identify effective biomarkers for prediction. Methods: A total 2325 were integrated into four independent sets (training set, validation set I, II and III) after removing batch effects in our study. We applied microarray data algorithm screen differentially expressed genes training set. The most robust markers identified using LASSO-Cox regression model, which...
This cross-sectional study estimated three clinical tools including the Osteoporosis Self-Assessment Tool for Asians (OSTA), Body Mass Index (BMI), and Beijing Friendship Hospital Self-assessment Elderly Male (BFH-OSTM) identifying primary osteoporosis found optimal cut-off values in an elderly Han male population.We conducted a study, enrolling 400 community-dwelling males aged ≥50 from 8 medical institutions. was diagnosed as T-score of -2.5 standard deviations or lower than that average...