A5102502544- Mesenchymal stem cell research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Tissue Engineering and Regenerative Medicine
- Apelin-related biomedical research
- Digital Transformation in Law
- Remote Sensing and Land Use
- Ion Channels and Receptors
- Law, AI, and Intellectual Property
- Landslides and related hazards
- Nuclear Receptors and Signaling
- Legal and Policy Issues
- Biochemical Analysis and Sensing Techniques
- Geomechanics and Mining Engineering
- Evaluation Methods in Various Fields
- Thermodynamic and Structural Properties of Metals and Alloys
- Neurobiology and Insect Physiology Research
- Muscle Physiology and Disorders
- Regulation of Appetite and Obesity
- Gout, Hyperuricemia, Uric Acid
- Cardiac Fibrosis and Remodeling
- Environmental and Agricultural Sciences
- Osteoarthritis Treatment and Mechanisms
- Organ Transplantation Techniques and Outcomes
- Extracellular vesicles in disease
- Peroxisome Proliferator-Activated Receptors
Moscow State University
2025
Lomonosov Moscow State University
2025
China Earthquake Administration
2024
Max Planck Institute for the Science of Human History
2022
Xiamen University
2022
Institute of Law
2021
Central University of Finance and Economics
2021
Zhengzhou Central Hospital
2020
City University of New York
2020
The Graduate Center, CUNY
2020
We tested the hypothesis that activation of transient receptor potential vanilloid type-1 (TRPV1) by capsaicin prevents adipogenesis. TRPV1 channels in 3T3-L1-preadipocytes and visceral adipose tissue from mice humans were detected immunoblotting quantitative real-time RT-PCR. The effect on cytosolic calcium was determined fluorometrically human fat tissue. Adipogenesis stimulated oil red O-staining intracellular lipid droplets, triglyceride levels, expression peroxisome...
The use of adult stem cells is limited by the quality and quantity host cells. It has been demonstrated that Wharton's jelly–derived mesenchymal (WJMSCs), a primitive stromal population, could integrate into ischemic cardiac tissues significantly improve heart function. In this randomized, controlled trial, our aim was to assess safety efficacy intracoronary WJMSCs in patients with ST-elevation acute myocardial infarction (AMI). multicenter 116 MI were randomly assigned receive an infusion...
The article provides an interdisciplinary analysis of the "Dance with Wooden Drums" (木鼓舞) Miao people (苗族), which is a unique form traditional art that combines elements ritual practice, artistic expression and cultural identity. goal this study was to identify cultural, historical significance ethnic group by analyzing stylistic features. novelty research lies in its identification performance. Adopting comprehensive scientific approach material Drums", develops model for morphological...
At present, there are still significant barriers that impede the clinical use of hESCs and iPS cells, including ethics, immunorejection, tumorigenesis from hESCs, teratoma formation cells. It is therefore necessary to search for alternative sources stem WJ-MSCs originate embryonic epiblasts possess properties intermediate between adult However, stemness molecules in remain unclear compared those hESCs. In present study, we isolated by a nonenzymatic method. Further, using microarray analysis...
Objective Activation of nonselective cation channels the transient receptor potential canonical (TRPC) family has been associated with hypertension. Whether store-operated channels, which are activated after depletion intracellular stores, or second-messenger-operated by 1-oleoyl-2-acetyl-sn-glycerol, affected in essential hypertension is presently unknown. Methods Using a polymerase chain reaction, an in-cell western assay and fluorescent dye technique we studied TRPC3, TRPC5, TRPC6...
Endothelial dysfunction can be observed in preatherosclerotic conditions. However, its pathogenetic role hypertension is still controversial. Endothelial-dependent changes of blood pressure (BP) and expression endothelial nitric oxide synthase (eNOS) were evaluated cold-induced hypertensive rats. Wistar rats exposed to cold stress for 8 weeks. Exposure significantly increased the systolic BP The infusion acetylcholine lowered mean arterial control by 48 ± 2% 32 1% acetylcholine-induced...
Our previous study demonstrated that apelin level increased significantly after the treatment of intracoronary implantation bone marrow mononuclear cells (BMMCs), followed by improvement cardiac function in patients with severe ischemic heart failure. The present studies both vivo and vitro explored whether mesenchymal stem derived from (BMSCs) activate apelin-APJ pathway when differentiating into cardiomyogenic cells. Isolated BMSCs rat femurs tibias were cultured expanded for three...
We previously reported that intracoronary implantation of bone marrow mononuclear cells (BMMC) into ischemic hearts improved cardiac function after myocardial infarction. However, the mechanisms have not been elucidated. The present study investigates whether apelin, a newly described inotropic peptide with important cardiovascular regulatory properties, contributes to functional improvement in patients severe heart failure cell transplantation. Forty consecutive secondary infarction were...
Our previous study demonstrated that the apelin–APJ pathway contributed to myocardial regeneration and functional recovery after bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation during differentiation of BM-MSCs into cardiomyogenic cells in acute infarction (AMI) rat models. However, underlying mechanisms by which apelin promotes cardiac repair have not been completely clarified. In present study, we investigated whether could mobilize activate endogenous progenitors,...
Two polymorphic sites in the first exon 1 of MSTN gene 180 Wenling grass-chicken including 3 lines were studied by PCR-RFLP method,and its genetic effects on carcass traits researched. The results showed that 2 genotypes (MN and NN) G(2100)A locus identified Bsh1236 I (AA, AB BB) G(2109)A Msp I, 5 emerged while com-analyzing loci. chi2 test indicated genotype frequencies had no significant deviation (P > 0.05) among lines. analysis variance different <0.01 or P < percent. multiple...
Abstract Currently, the original Miedema mixing enthalpy model yields calculation results that exhibit some discrepancies when compared to experimental data. Therefore, improving precision of is essential advance its development and application in developing samarium–cobalt permanent magnet alloys. To address this issue, enthalpies for Sm–(Co, Cu, Fe, Zr) binary alloys were calculated using modified model. In addition, (Δ H ), excess entropy ( S E Gibbs free energy G component activity α )...
Introduction: The relationship between uric acid (UA) levels and cardiovascular cerebrovascular diseases (CCVD) is controversial. A two-sample Mendelian randomization (MR) study was conducted to explore the causal effects of UA on CCVD. Methods: Genetic variants strongly associated with were selected as instrumental variables from Genome-Wide Association Study (GWAS) dataset. GWAS data, sourced Global Urate Genetics Consortium (GUGC), comprised a sample size 110,347 individuals. CCVD...
Algorithmic discrimination is a kind of unreasonable, unequal treatment based on algorithms, which widely existing in all areas our social and economic life. Compared with traditional discrimination, algorithmic inherent, professional concealed. In practice, both market forces government regulation have certain limitations regulating discrimination. On the one hand, enterprise autonomy often fails due to benefit considerations, while industry self-discipline lacks set mature effective rules....
Rainfall is one of the most important factors slope stability. After "5.12" earthquake, there are a large number loose solid produced by earthquake on mountain, which leads to soils strength loss in disaster zones. and induces landslides collapses easily heavy rainfall condition. The soil parameters obtained from tests, scene investigation Erman mountain landslide Han Yuan County, new developed control ArcGIS obtain intuitive warning graphs have been carried out. Results show that picture...
Aimed to the problem of excavation and stability for a high steep rocky slope, with design height 90.23m, this paper grasped engineering geological conditions physical mechanical properties rock mass by such following methods as field survey, measuring, drilling sampling laboratory test. Based on this, comparative analysis two different ways was conducted using large discrete element program-UDEC. The included stress-strain law deformation failure trends slope when adopting slow...
Compressive sensing (CS) is an emerging technology which can capture and represent compressible signal at a rate below the Nyquist of sampling. In this paper, perceptual compressive scheme proposed. Firstly, two-dimentional Discrete Wavelet Transform (DWT) applied for sparse representation feature calculated different wavelet coefficient. Then coefficients are partitioned into four blocks. According to features, weighted CS measurement performed block respectively. Experimental results show...
The geological disaster is one of the important research contents field Earth Science. In this paper, method theoretical knowledge,field surveys and laboratory experiments adopted.The Erman Mountain in Hanyuan County object.Analysis environmental conditions,development characteristics mechanism. Select characters landslide, structure, elevation, slope, earthquake, rainfall other factors as analysis variables. Combine GIS with fuzzy mathematical evaluation method, develop landslide stability...
Dialysis and transplant -Mortality outcomes vi415 onset of diabetes was immunostained for p27 Kip1 (quantitative analysis, number stained cell/glomeruli, n=6 per group).Results: In podocytes, HG-induced hypertrophy completely abolished in the presence PTHrP neutralizing antibodies.This effect also associated with an inhibition overexpression.PTHrP is able to upregulate kip1 on these cells.Interestingly, PTHrP-induced overexpression prevented GF, a PKC inhibitor ERK inhibitor, U0126.Moreover,...
Abstract Objective: We aimed to determine the significance of MSC-derived exosomes (MSC-Exos) in chondrocyte autophagy under normal and inflammatory conditions. Design: Human umbilical cord-derived MSCs (hMSCs) were cultured vitro. hMSC-Exos( EX） isolated by an ultracentrifugation method. Transmission electron microscopy western analysis used identify exosomes. chondrocytes extracted from five adult males with OA undergoing total knee arthroplasty. Primary cultures patients stimulated 50...