A5027245585- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrowetting and Microfluidic Technologies
- Advanced Memory and Neural Computing
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Cancer Cells and Metastasis
- Pluripotent Stem Cells Research
- Muscle activation and electromyography studies
- Single-cell and spatial transcriptomics
- Biosensors and Analytical Detection
- Nanopore and Nanochannel Transport Studies
- Pain Mechanisms and Treatments
- Planarian Biology and Electrostimulation
- Advanced biosensing and bioanalysis techniques
- Electrohydrodynamics and Fluid Dynamics
- Orbital Angular Momentum in Optics
- Mesenchymal stem cell research
- Laser Material Processing Techniques
- Laser-Plasma Interactions and Diagnostics
- Motor Control and Adaptation
- Numerical methods in engineering
- Electronic and Structural Properties of Oxides
Indiana University Bloomington
2018-2025
Shanghai Sixth People's Hospital
2025
Shanghai Jiao Tong University
2025
South China Normal University
2024
Beijing Transportation Research Center
2024
Wuhan Polytechnic University
2024
Indiana University – Purdue University Indianapolis
2019-2023
Indiana University School of Medicine
2019-2023
Indiana University Health
2019-2023
Jinan Central Hospital
2012-2023
Significance We present 3D acoustic tweezers, which can trap and manipulate single cells particles along three mutually orthogonal axes of motion by recourse to surface waves. use tweezers pick up cells, or entire cell assemblies, deliver them desired locations create 2D patterns, print the into complex shapes. This technology is thus shown offer better performance over prior manipulation techniques in terms both accurate precise a noninvasive, label-free, contactless manner. method offers...
Significance We present a unique acoustic well approach that can precisely control cell-to-cell distance and cell–cell interactions. Our technology achieve high precision throughput simultaneously while preserving the integrity of cells. It is capable creating cell assemblies with precise spatial both in suspension on substrate. envision exploitation this powerful technology, for example, study interactions fields, such as immunology, developmental biology, neuroscience, cancer metastasis,...
The use of adult stem cells is limited by the quality and quantity host cells. It has been demonstrated that Wharton's jelly–derived mesenchymal (WJMSCs), a primitive stromal population, could integrate into ischemic cardiac tissues significantly improve heart function. In this randomized, controlled trial, our aim was to assess safety efficacy intracoronary WJMSCs in patients with ST-elevation acute myocardial infarction (AMI). multicenter 116 MI were randomly assigned receive an infusion...
For decades, scientists have pursued the goal of performing automated reactions in a compact fluid processor with minimal human intervention. Most advanced fluidic handling technologies (e.g., microfluidic chips and micro-well plates) lack rewritability, associated benefits multi-path routing re-programmability, due to surface-adsorption-induced contamination on contacting structures. This limits their processing speed complexity reaction test matrices. We present contactless droplet...
Abstract Transdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute diseases mainly due to their inability timely administrate therapeutics precisely regulate pharmacokinetics within a short time window. Here we report the development of active acoustic metamaterials-driven transdermal rapid on-demand disease management. Through integration metamaterials, compact therapeutic patch is integrated...
Multifunctional Janus particles have a variety of applications in wide range fields. However, to achieve many these applications, high-throughput, low-cost techniques are needed synthesize with precise control the various structural/physical/chemical properties. Microfluidics provides unique platform fabricate using carefully controlled liquid flow microfluidic channels form droplets and types solidification methods solidify them into particles. In this Focus article, we summarize most...
The emerging field of droplet microfluidics requires effective on-chip handling and sorting droplets. In this work, we demonstrate a microfluidic device that is capable picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This integrates single-layer channel with interdigital transducers (IDTs) to achieve generation sorting. Within the SSAW field, experience an radiation force are pushed toward pressure node. As result, by tuning frequency...
A 3D acoustic tweezers platform is developed to fabricate size-controllable multicellular spheroids in a rapid and high-throughput manner, utilizing the Gor'kov potential field microstreaming.
We present a theoretical analysis and experimental demonstration of particle trapping manipulation around optothermally generated bubbles. show that located within 500 μm surface bubble can be attracted towards by drag force resulting from convective flow. Once the comes in contact with bubble's surface, balance between tension forces pressure traps on allowing to move without detaching. The proposed mechanism is confirmed computational fluid dynamics simulations, calculations, experiments....
Patterning of nanowires in a controllable, tunable manner is important for the fabrication functional nanodevices. Here we present simple approach nanowire patterning using standing surface acoustic waves (SSAW). This technique allows construction large-scale arrays with well-controlled geometry and spacing within 5 s. In this approach, SSAWs were generated by interdigital transducers, which induced periodic alternating current (ac) electric field on piezoelectric substrate consequently...
We developed a standing surface acoustic wave (SSAW)-based cell sorting device. The throughput of our device has been significantly improved by using focused interdigital transducers (FIDTs) as SSAW generator.
Current treatments of bacterial biofilms are limited by the poor penetration antibiotics through their physical barrier as well significant off-target toxicity and induction antibiotic resistance. Here we report a microneedle patch-mediated treatment for effective elimination penetrating biofilm specifically delivering to regions active growth. We fabricated patches with self-dissolvable microneedles needle tips loaded chloramphenicol (CAM)-bearing gelatinase-sensitive gelatin nanoparticles...
Nanoparticles are regarded as promising transfection reagents for effective and safe delivery of nucleic acids into a specific type cells or tissues providing an alternative manipulation/therapy strategy to viral gene delivery. However, the current process searching novel materials is limited due conventional low-throughput time-consuming multistep synthetic approaches. Additionally, approaches frequently accompanied with unpredictability continual optimization refinements, impeding flexible...
Prenatal cannabis exposure (PCE) influences human brain development, but it is challenging to model PCE using animals and current cell culture techniques. Here, we developed a one-stop microfluidic platform assemble cerebral organoids from embryonic stem cells (hESC) investigate the effect of on early development. By incorporating perfusable chambers, air-liquid interface, protocol, this can simplify fabrication procedure produce large number (169 per 3.5 cm × device area) without fusion, as...
Three-dimensional (3D) culture of multicellular spheroids, offering a desirable biomimetic microenvironment, is appropriate for recapitulating tissue cellular adhesive complexity and revealing more realistic drug response.
By exploiting surface acoustic waves and a coupling layer technique, cells are patterned within photosensitive hydrogel fiber to mimic physiological cell arrangement in tissues. The aligned cell–polymer matrix is polymerized with short exposure UV light the extracted. These fibers manipulated into simple complex architectures, demonstrating feasibility for tissue-engineering applications.
The fusion of human organoids holds promising potential in modeling physiological and pathological processes tissue genesis organogenesis. However, current fused organoid models face challenges high heterogeneity variable reproducibility, which may stem from the random heterogeneous organoids. Thus, we developed a simple versatile acoustofluidic method to improve standardization via controllable spatial arrangement By regulating dynamic acoustic fields within hexagonal device, can rotate,...