A5017376448- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Electrowetting and Microfluidic Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Biosensors and Analytical Detection
- 3D Printing in Biomedical Research
- Photoacoustic and Ultrasonic Imaging
- Nanopore and Nanochannel Transport Studies
- Electrohydrodynamics and Fluid Dynamics
- Acoustic Wave Resonator Technologies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Graphene research and applications
- Electrostatics and Colloid Interactions
- Microbial Community Ecology and Physiology
- Digital Platforms and Economics
- Ultrasound and Cavitation Phenomena
- Laser Material Processing Techniques
- Rare-earth and actinide compounds
- Orbital Angular Momentum in Optics
- Electrical and Bioimpedance Tomography
- Iron-based superconductors research
- Complex Network Analysis Techniques
- ICT Impact and Policies
- Advanced machining processes and optimization
- Advanced Measurement and Metrology Techniques
Duke University
2018-2025
Tsinghua University
2024
Insilicos (United States)
2024
Insilico Medicine (United States)
2024
China Southern Power Grid (China)
2023-2024
Hebei Normal University
2021-2024
National University of Defense Technology
2023
Beijing Jiaotong University
2018-2022
Tianjin University
2021
Zhejiang University
2018-2020
Acoustic tweezers have recently raised great interest across many fields including biology, chemistry, engineering, and medicine, as they can perform contactless, label-free, biocompatible, precise manipulation of particles cells. Here, we present wave number-spiral acoustic tweezers, which are capable dynamically reshaping surface (SAW) wavefields to various pressure distributions facilitate dynamic programmable particle/cell manipulation. SAWs propagating in multiple directions be...
For decades, scientists have pursued the goal of performing automated reactions in a compact fluid processor with minimal human intervention. Most advanced fluidic handling technologies (e.g., microfluidic chips and micro-well plates) lack rewritability, associated benefits multi-path routing re-programmability, due to surface-adsorption-induced contamination on contacting structures. This limits their processing speed complexity reaction test matrices. We present contactless droplet...
Acoustofluidic centrifugation enables the spinning of a fluidic droplet and nanoparticle enrichment separation.
Raman-activated cell sorting (RACS) is a promising single-cell technology that holds several significant advantages, as RACS label-free, information-rich, and potentially in situ. To date, the ability of technique to identify single cells high-speed flow has been limited by inherent weakness spontaneous Raman signal. Here we present an alternative pause-and-sort microfluidic system combines positive dielectrophoresis (pDEP) for trap release with solenoid-valve-suction-based switch...
Microfluidic fluorescence-activated cell sorters (μFACS) have attracted considerable interest because of their ability to identify and separate cells in inexpensive biosafe ways. Here a high-performance μFACS is presented by integrating standing surface acoustic wave (SSAW)-based, 3D cell-focusing unit, an in-plane fluorescent detection SSAW-based cell-deflection unit on single chip. Without using sheath flow or precise rate control, the technique can focus into file at designated position....
Acoustic tweezers enable contactless, dynamic, precise, and multifunctional manipulation of bioparticles in Petri dishes.
A disposable acoustofluidic platform was developed for nano/microparticle separation with high versatility, precision, and biocompatibility.
Acoustic-based techniques can manipulate particles in a label-free, contact-free, and biocompatible manner. However, most previous work acoustic manipulation has been constrained by axisymmetric patterns of pressure nodes antinodes. Acoustic holography is an emerging technique that offers the potential to generate arbitrary distributions which be applied particle with higher degrees freedom. since current rely on radiation forces, decrease dramatically when target size decreases, they have...
Sarcasm is sophisticated linguistic expression and commonly observed on social media e-commerce platforms. Failure to detect sarcastic expressions in natural language processing tasks, such as opinion mining sentiment analysis, leads poor model performance. Traditional approaches rely heavily discrete handcrafted features will incur enormous human costs. It was not until recent that scholars began employ neural networks address these limitations have achieved new state-of-the-art In this...
Acoustofluidics, the fusion of acoustics and microfluidic techniques, has recently seen increased research attention across multiple disciplines due in part to its capabilities contactless, biocompatible, precise manipulation micro-/nano-objects. Herein, a bimodal signal amplification platform which relies on acoustofluidics-induced enrichment nanoparticles is introduced. The dual-function biosensor can perform sensitive immunofluorescent or surface-enhanced Raman spectroscopy (SERS)...
Controllable, precise, and stable rotational manipulation of model organisms is valuable in many biomedical, bioengineering, biophysics applications. We present an acoustofluidic chip capable rotating Caenorhabditis elegans (C. elegans) both static continuous flow a controllable manner. Rotational was achieved by exposing C. to surface acoustic wave (SAW) field that generated vortex distribution inside microchannel. By selectively activating interdigital transducers, we bidirectional...
Synthesis of nanoparticles and particulate nanomaterials with tailored properties is a central step toward many applications ranging from energy conversion imaging/display to biosensing nanomedicine. While existing microfluidics-based synthesis methods offer precise control over the process, most them rely on passive, partial mixing reagents, which limits their applicability potentially, adversely alter synthesized products. Here, an acoustofluidic (i.e., fusion acoustic microfluidics)...
Abstract Modern biomedical research and preclinical pharmaceutical development rely heavily on the phenotyping of small vertebrate models for various diseases prior to human testing. In this article, we demonstrate an acoustofluidic rotational tweezing platform that enables contactless, high-speed, 3D multispectral imaging digital reconstruction zebrafish larvae quantitative phenotypic analysis. The acoustic-induced polarized vortex streaming achieves contactless rapid (~1 s/rotation)...
The integration of acoustics and microfluidics (termed acoustofluidics) presents a frontier in the engineering functional micro-/nanomaterials. Acoustofluidic techniques enable active precise spatiotemporal control matter, providing great potential for design advanced nanosystems with tunable material properties. In this work, we introduce an acoustofluidic approach multifunctional three-dimensional nanostructure arrays demonstrate their enrichment biosensing applications. particular, our...
Abstract Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side effects. However, development exosome-encapsulated nanocarriers is limited by low loading efficiencies and/or complex, time-consuming processes. Herein, we have developed an acoustofluidic device that simultaneously performs both encapsulation. By synergistically leveraging acoustic radiation force, microstreaming, shear stresses...
Acoustic black holes offer superior capabilities for slowing down and trapping acoustic waves various applications such as metastructures, energy harvesting, vibration noise control. However, no studies have considered the linear nonlinear effects of on micro/nanoparticles in fluids. This study presents acoustofluidic (AFBHs) that leverage controlled interactions between AFBH-trapped wave particles droplets to enable versatile particle manipulation functionalities, translation,...
Abstract Extracellular vesicles (EVs) have been identified as promising biomarkers for the noninvasive diagnosis of various diseases. However, challenges in separating EVs from soluble proteins resulted variable EV recovery rates and low purities. Here, we report a high-yield ( > 90%) rapid < 10 min) isolation method called FL occulation via O rbital A coustic T rapping (FLOAT). The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate controllably heat liquid...
The complex interaction of spin, valley and lattice degrees freedom allows natural materials to create exotic topological phenomena. interplay between wave hydrodynamics could offer promising opportunities for visualizing physics manipulating bioparticle unconventionally. Here we present acoustofluidic chips illustrate the elastic spin nonlinear fluid dynamics. We created streaming vortices chiral swirling patterns backward-immune particle transport. Using tracer particles, observed arrays...
Advances in lab-on-a-chip technologies are driven by the pursuit of programmable microscale bioreactors or fluidic processors that mimic electronic functionality, scalability, and convenience. However, few mechanisms allow for basic logic operations on rewritable paths due to cross-contamination, which leads random interference between "fluidic bits" droplets. Here, we introduce a mechanism allows contact-free gating individual droplets based scalable features acoustic streaming vortices...
Decomposition and control of acoustic streaming enable contact-free manipulation bioanalytes digitalized liquid handling.
High-precision isolation of small extracellular vesicles (sEVs) from biofluids is essential toward developing next-generation liquid biopsies and regenerative therapies. However, current methods sEV separation require specialized equipment time-consuming protocols have difficulties producing highly pure subpopulations sEVs. Here, we present Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER), which allows single-step, rapid (<10 min), high-purity (>96% exosomes, >80%...