A5072488525- Nanoplatforms for cancer theranostics
- Supramolecular Chemistry and Complexes
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Supramolecular Self-Assembly in Materials
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Acoustic Wave Resonator Technologies
- RNA Interference and Gene Delivery
- Lanthanide and Transition Metal Complexes
- Photodynamic Therapy Research Studies
- Chemical Synthesis and Reactions
- Advanced Biosensing Techniques and Applications
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Crystallization and Solubility Studies
- Polymer Surface Interaction Studies
- X-ray Diffraction in Crystallography
- Piezoelectric Actuators and Control
Northwest A&F University
2016-2025
First Hospital of Jilin University
2022-2025
Jilin University
2022-2025
Duke University
2020-2024
China Academy of Building Research
2023-2024
Beijing Agricultural Machinery Research Institute
2013-2023
Zhejiang University of Water Resource and Electric Power
2023
Zhejiang Center for Disease Control and Prevention
2023
Harbin Institute of Technology
2016-2022
State Key Laboratory of Robotics and Systems
2022
Abstract A novel ferrocenium capped amphiphilic pillar[5]arene (FCAP) was synthesized and self‐assembled to cationic vesicles in aqueous solution. The vesicles, displaying low cytotoxicity significant redox‐responsive behavior due the redox equilibrium between cations ferrocenyl groups, allow building an ideal glutathione (GSH)‐responsive drug/siRNA co‐delivery system for rapid drug release gene transfection cancer cells which higher GSH concentration exists. This is first report of...
Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic (CDT) based Fenton/Fenton-like reactions a non-invasive cancer treatment, which converts hydrogen peroxide (H2O2) found locally into lethal hydroxyl radicals (OH) through exploitation of transition metal ions catalysts acidic microenvironment (TME) suitable effective oncotherapy. Metal-organic...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSupramolecular Vesicles Based on Complex of Trp-Modified Pillar[5]arene and Galactose Derivative for Synergistic Targeted Drug DeliveryKui Yang, Yincheng Chang, Jia Wen, Yuchao Lu, Yuxin Pei*, Shoupeng Cao, Feng Wang, Zhichao Pei*View Author Information College Science, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic China*Z. Pei. E-mail: [email protected]*Y. protected]Cite this: Chem. Mater. 2016, 28, 7,...
In aqueous solution, probe 1 selectively reacts with hydrazine (N2H4), leading to a 30.5-fold turn-on fluorescence response at 560 nm. Probe can detect in both solution and gas state by color changes from readily prepared strips. Furthermore, it was found that is able Hela cells.
Acoustofluidics, the fusion of acoustics and microfluidic techniques, has recently seen increased research attention across multiple disciplines due in part to its capabilities contactless, biocompatible, precise manipulation micro-/nano-objects. Herein, a bimodal signal amplification platform which relies on acoustofluidics-induced enrichment nanoparticles is introduced. The dual-function biosensor can perform sensitive immunofluorescent or surface-enhanced Raman spectroscopy (SERS)...
The integration of acoustics and microfluidics (termed acoustofluidics) presents a frontier in the engineering functional micro-/nanomaterials. Acoustofluidic techniques enable active precise spatiotemporal control matter, providing great potential for design advanced nanosystems with tunable material properties. In this work, we introduce an acoustofluidic approach multifunctional three-dimensional nanostructure arrays demonstrate their enrichment biosensing applications. particular, our...
Abstract Mild magnetic hyperthermia therapy (MMHT) holds great potential in treating deep‐seated tumors, but its efficacy is impaired by the upregulation of heat shock proteins (HSPs) during treatment process. Herein, Lac‐FcMOF, a lactose derivative (Lac‐NH 2 ) modified paramagnetic metal‐organic framework (FcMOF) with property and thermal stability, has been developed to enhance MMHT therapeutic efficacy. In vitro studies showed that Lac‐FcMOF aggravates two‐way regulated redox...
The problem of antibiotic resistance seriously affects the treatment bacterial infections, so there is an urgent need to develop novel antibiotic-independent antimicrobial strategies. Herein, a urease-driven bowl-like mesoporous polydopamine nanorobot (MPDA@ICG@Ur@Man) based on single-wavelength near-infrared (NIR) remote photothermal acceleration achieve antibiotic-free phototherapy(photothermal therapy, PTT, plus photodynamic PDT) first reported. smart nanorobots can perform active...
Metal–organic frameworks (MOFs) hold tremendous potential in cancer therapy due to their remarkable structural and functional adaptability, enabling them serve as nanocarriers for biopharmaceuticals nanoreactors organizing cascade bioreactions. Nevertheless, MOFs are predominantly utilized biologically inactive carriers most cases. Developing nanoscale prodrug suitable biomedical applications remains a huge challenge. In this study, we have designed novel nano-MOFs (nMOFs, named DCCMH) using...
A glyco-nanovesicle (Lac-SS-DCM) is self-assembled by a rationally designed amphiphilic lactose derivative (1), which features surface corona, disulfide linkage, and an activatable DCM near-infrared (NIR) probe moiety. Taking advantage of the Lac-SS-DCM can be triggered to disassemble glutathione (GSH) simultaneously activate dormant NIR, allows for drug-loaded vesicle capable both therapies in cancer cells where higher GSH concentration exists real-time monitoring drug release. Furthermore,...
A novel stick-slip type piezoelectric rotary actuator is proposed in this paper. The equips with a parallelogram driving mechanism to generate pair of variable force couple drive the rotor. Two piezo-stacks are used deform realize large range motions high resolution both forward and backward directions. By utilizing pseudo-rigid-body method, geometric model established analyze motion actuator. Finite element analysis conducted simulate deformation mechanism. prototype fabricated series...
A novel core-shell metal organic framework (MOF), Cu-MOF@SMON/DOX-HA, was fabricated using 3-amino-1,2,4-triazole (3-AT) and organosilicon for combined chemo-chemodynamic therapy with high drug-loading capacity, pH/GSH dual-responsiveness, good biocompatibility. The Cu-MOF@SMON/DOX-HA could not only generate reactive oxygen species, but also effectively consume glutathione (GSH) to induce cell ferroptosis. This work involves the modification of on surface MOFs, which possess performance in...
A supramolecular NIR nanophotosensitizer for dual-modal imaging and ablation of tumors was constructed by loading disulfiram (DSF) into the vesicle from host–guest complex lactose-capped pillar[5]arene (LacP5) with aza-BODIPY derivative (BSTA).
Impacts of exposure to particulate matter can be wide-ranging, with some evidence suggesting potential impacts on nervous system, cognition, and productivity. However, most date addresses ambient chronic outcomes limited research indoor short-term PM2.5 cognitive performance. Hence, the aim this study was evaluate if there is a relationship between within workplace context performance in adults. A randomized single-blind cross-over trial conducted an urban mixed-mode ventilated office...