A5101963460- Cardiac Fibrosis and Remodeling
- Cell Adhesion Molecules Research
- Immune cells in cancer
- TGF-β signaling in diseases
- RNA Interference and Gene Delivery
- Signaling Pathways in Disease
- Protease and Inhibitor Mechanisms
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- GDF15 and Related Biomarkers
- Skin Protection and Aging
- Nanoplatforms for cancer theranostics
- Thermoregulation and physiological responses
- Lipid Membrane Structure and Behavior
- Medicinal Plants and Bioactive Compounds
- Peptidase Inhibition and Analysis
- Climate Change and Health Impacts
- Biomarkers in Disease Mechanisms
- Paraoxonase enzyme and polymorphisms
- Advanced Nanomaterials in Catalysis
- Chemotherapy-induced cardiotoxicity and mitigation
- Diabetes Management and Research
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Sodium Intake and Health
Zhejiang University
2024-2025
Zhejiang University of Science and Technology
2024
Albert Einstein College of Medicine
2020-2024
Xuzhou Medical College
2023
Affiliated Hospital of Guizhou Medical University
2023
Fudan University
2018-2020
Huashan Hospital
2018-2020
Repair of the infarcted heart requires TGF-β/Smad3 signaling in cardiac myofibroblasts. However, TGF-β–driven myofibroblast activation needs to be tightly regulated order prevent excessive fibrosis and adverse remodeling that may precipitate failure. We hypothesized induction inhibitory Smad, Smad7, restrain infarct activation, we examined molecular mechanisms Smad7 actions. In a mouse model nonreperfused infarction, Smad3 triggered synthesis α-SMA+ myofibroblasts, but not α-SMA–PDGFRα+...
Metal–organic frameworks (MOFs) hold tremendous potential in cancer therapy due to their remarkable structural and functional adaptability, enabling them serve as nanocarriers for biopharmaceuticals nanoreactors organizing cascade bioreactions. Nevertheless, MOFs are predominantly utilized biologically inactive carriers most cases. Developing nanoscale prodrug suitable biomedical applications remains a huge challenge. In this study, we have designed novel nano-MOFs (nMOFs, named DCCMH) using...
Background The triglyceride glucose-body mass index (TyG-BMI) is a surrogate indicator of insulin resistance. However, the association TyG-BMI with heart failure (HF) in individuals diabetes mellitus or prediabetes unknown. Methods This study included 7,472 participants aged 20–80 years old from National Health and Nutrition Examination Survey (2007–2018). was calculated as Ln [triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2] BMI, were categorized into tertiles based on levels....
Abstract Reliable tools for macrophage identification in mouse tissues are critical studies investigating inflammatory and reparative responses. Transgenic reporter mice anti-macrophage antibodies have been used as “specific pan-macrophage” markers many studies; however, organ-specific patterns of expression non-specific labeling other cell types, such fibroblasts, may limit their usefulness. Our study provides a systematic comparison normal injured tissues, using the CX3CR1 CSF1R lines...
Abstract Macrophages sense changes in the extracellular matrix environment through integrins and play a central role regulation of reparative response after myocardial infarction. Here we show that macrophage integrin α5 protects infarcted heart from adverse remodeling protective actions are associated with acquisition an angiogenic phenotype. We demonstrate myeloid cell- macrophage-specific knockout mice have accentuated post-infarction remodeling, accompanied by reduced angiogenesis...
The emergence of mRNA vaccines has heralded an epoch in disease prevention and treatment. Safe efficient delivery systems are highly desired for the widespread application therapeutics. Herein, we have designed a facile synthetic pathway producing ionizable lipids featuring various branched linkers. These been integrated into lipid nanoparticles (LNPs) to improve vaccines. influence linker structure on LNPs is currently underreported, yet it undeniably exerts substantial impact outcomes....
Recent studies have shown that TRPA1, a nonselective cation channel with high permeability to calcium, is expressed in many tissues of the cardiovascular system and involved pathogenesis diseases. However, role TRPA1 cardiac repair after myocardial infarction (MI) has not been clearly defined. The aim this study was confirm whether inhibition could attenuate MI-induced ischemia injury. C57BL/6 mice were subjected ligation left anterior descending coronary artery treated TRPA1-specific...
mRNA vaccines have been revolutionizing disease prevention and treatment. However, their further application is hindered by inflammatory side effects, primarily caused delivery systems such as lipid nanoparticles (LNPs). In response to this issue, we prepared cationic lipids (mLPs) derived from mildronate, a small-molecule drug, subsequently developed the LNP (mLNP-69) comprising low dose of mLP. Compared with (sLNP) based on SM-102, commercially available ionizable lipid, mLNP-69 ensures...
Abstract Oxidized low‐density lipoprotein (ox‐LDL)‐induced oxidative stress and apoptosis are considered as a critical contributor to atherosclerosis. MicroRNAs (miRNAs) have been reported versatile functions in all biological processes via directly suppressing target messenger RNA at posttranscriptional level. Although miRNA‐221 has implied be involved the regulation of atherosclerosis, underlying mechanism remains unclear. Here, we showed that ox‐LDL treatment remarkably suppressed...
Under the condition of lipopolysaccharide (LPS)/interferon (IFN)-γ activation, macrophage metabolism is converted from oxidative phosphorylation to glycolysis. In present work, we analysed whether glycolysis could affect interleukin (IL)-1β expression through altering histone acetylation levels in mouse bone marrow-derived macrophages. Immunocytochemistry and Western blot analysis are used characterize macrophages stimulated by LPS/IFN-γ. Real-time polymerase chain reaction enzyme-linked...
Abstract Smad7 restrains TGF‐β responses, and has been suggested to exert both pro‐ anti‐inflammatory actions that may involve effects on macrophages. Myocardial infarction triggers a macrophage‐driven inflammatory response not only plays central role in cardiac repair, but also contributes adverse remodeling fibrosis. We hypothesized macrophage expression regulate inflammation fibrosis the infarcted heart through suppression of or via TGF‐independent actions. In mouse model myocardial...
Vascular inflammation is a key factor in the pathogenesis of atherosclerosis. Salidroside an important active ingredient extracted from root Rhodiola rosea plant, which has been reported to have antioxidative, anti‑cancer, neuroprotective and cardioprotective effects. However, effects salidroside on vascular not clarified. The purpose present study was investigate protective against tumor necrosis (TNF)‑α‑induced cardiac microvascular endothelial cells (CMECs), specific cell type derived...
Abstract Background In previous studies, sun-protective behaviors increased cardiovascular incidence. Our present article is to further analyze the potential relationship between (staying in shade, wearing long-sleeved clothing, and applying sunscreen) hypertension. Method The cross-sectional study evaluated 8,613 participants (aged 20–60 years) from National Health Nutrition Examination Survey (NHANES) obtained 2009 2014. We performed multiple logistic regression analysis examine Subgroup...
<title>Abstract</title> Metal-organic frameworks (MOFs) hold tremendous potential in cancer therapy due to their remarkable structural and functional adaptability, enabling them serve as nanocarriers for biopharmaceuticals nanoreactors organizing cascade bioreactions. Nevertheless, MOFs are predominantly utilized biologically inactive carriers most cases. Developing nanoscale prodrug suitable biomedical applications remains a huge challenge. In this study, we have designed novel nano-MOFs...
Abstract Background In previous studies, sun-protective behaviors increased cardiovascular incidence. Our present article is to further analyze the potential relationship between (staying in shade, wearing long-sleeved clothing, and applying sunscreen) hypertension. Method The cross-sectional study evaluated 8,613 participants (aged 20–60 years) from National Health Nutrition Examination Survey (NHANES) obtained 2009 2014. We performed multiple logistic regression analysis examine Subgroup...
Abundant macrophages infiltrate the infarcted heart and play a critical role in repair, remodeling fibrosis. Macrophages sense changes extracellular matrix (ECM) environment through Integrins, thus activating signaling pathways that regulate their function. Analysis of our RNA sequencing data identified integrin α5 (Itgα5) as one most upregulated genes infarct macrophages. Accordingly, we hypothesized transduces ECM-derived signals, regulating responses for repair heart.In order to study...