A5101562905- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Advanced battery technologies research
- Traditional Chinese Medicine Analysis
- RNA Research and Splicing
- Genetics and Plant Breeding
- Genetic Mapping and Diversity in Plants and Animals
- RNA Interference and Gene Delivery
- Electrocatalysts for Energy Conversion
- Traditional Chinese Medicine Studies
- Plant-based Medicinal Research
- Plant Molecular Biology Research
- Supercapacitor Materials and Fabrication
- Hepatitis B Virus Studies
- Genetic and phenotypic traits in livestock
- Cancer-related Molecular Pathways
- CRISPR and Genetic Engineering
- Fuel Cells and Related Materials
- DNA Repair Mechanisms
- Biosensors and Analytical Detection
- Circular RNAs in diseases
- Nanomaterials for catalytic reactions
- Cancer Research and Treatments
China Association of Acupuncture-Moxibustion
2025
Beijing University of Chinese Medicine
2022-2025
Guizhou Institute of Technology
2019-2024
Army Medical University
2022-2024
Southwest Hospital
2022-2024
Guangdong Medical College
2023
Guangzhou University
2023
Texas A&M University
2009-2022
Indiana University Health
2018-2022
Indiana University – Purdue University Indianapolis
2018-2022
In addition to regulating growth and development, the most important function of microRNAs (miRNAs) in plants is regulation a variety cellular processes underlying plant adaptation environmental stresses. To gain deep understanding mechanism drought tolerance rice, genome-wide profiling analysis miRNAs was carried out drought-challenged rice across wide range developmental stages, from tillering inflorescence formation, using microarray platform. Among 30 identified as significantly down- or...
Oxidation of 5-methylcytosine in DNA by ten-eleven translocation (Tet) family enzymes has been demonstrated to play a significant role epigenetic regulation mammals. We found that Tet also possess the activity catalyzing formation 5-hydroxymethylcytidine (5-hmrC) RNA vitro. In addition, catalytic domains all three as well full-length Tet3 could induce 5-hmrC human cells. Moreover, was present at appreciable levels (∼1 per 5000 5-methylcytidine) mammalian cells and tissues. Our results...
Active DNA demethylation is an important part of epigenetic regulation in plants and animals. How active regulated its relationship with histone modification patterns are unclear. Here, we report the discovery IDM1, a regulator Arabidopsis. IDM1 required for preventing hypermethylation highly homologous multicopy genes other repetitive sequences that normally targeted by Repressor Silencing 1 related 5-methylcytosine glycosylases. binds methylated at chromatin sites lacking H3K4 di- or...
The present study was performed to understand the effects of high temperature (HT) during filling on expression storage proteins and quality rice grains. HT (35/30 °C day/night) reduced weight, amylose content, flour gel consistency It increased accumulation all classes at early stage but decreased prolamins maturation. For albumins, expressions cyclophilin 2, peroxiredoxin, HSP16.9 were differentially enhanced by HT. globulins, globulin that glyoxalase I peroxiredoxin. transcription genes...
Three-dimensional (3D) culture of multicellular spheroids, offering a desirable biomimetic microenvironment, is appropriate for recapitulating tissue cellular adhesive complexity and revealing more realistic drug response.
Abstract Dysregulated energetic metabolism has been recently identified as a hallmark of cancer. Although mutations in metabolic enzymes hardwire to tumourigenesis, they are relatively infrequent ovarian More often, cancer is re-engineered by altered abundance and activity the enzymes. Here we identify ubiquitin-specific peptidase 13 (USP13) master regulator that drives metabolism. USP13 specifically deubiquitinates thus upregulates ATP citrate lyase oxoglutarate dehydrogenase, two key...
Abstract A novel gene, OsAHL1, containing an AT-hook motif and a PPC domain was identified through genome-wide profiling analysis of mRNAs by comparing the microarray drought-challenged versus normally watered rice. The results indicated OsAHL1 has both drought avoidance tolerance that could greatly improve resistance rice plant. Overexpression enhanced multiple stress tolerances in plants during seedling panicle development stages. Functional studies revealed regulates root under condition...
ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) encodes 12 pre-microRNAs (pre-miRNAs). Current studies have shown that these miRNAs are involved in regulation of viral and host gene expression, implicating a role the maintenance latency suppression antiviral innate immunity. However, functions remain largely unknown. On basis sequence homology between oncogenic miR-155 KSHV-encoded miR-K12-11, we hypothesized miR-K12-11 could attenuate transforming growth factor β (TGF-β) signaling,...
Posttranscriptional maturation is a critical step in microRNA (miRNA) biogenesis that determines mature miRNA levels. In addition to core components (Drosha and DGCR8 [DiGeorge syndrome region gene 8]) the microprocessor, regulatory RNA-binding proteins may confer specificity for recruiting processing of individual primary miRNAs (pri-miRNAs). Here, we identify DDX1 as protein promotes expression subset miRNAs, including five members microRNA-200 (miR-200) family four an eight-miRNA...
Defective cobalt oxide hydrate nanosheets with abundant oxygen vacancies and high porosity were fabricated via room-temperature reductive treatments, they performed well in the electrocatalytic oxidation reaction of 5-hydroxymethylfurfural.
Expression of microRNAs (miRNAs) involves transcription miRNA genes and maturation the primary transcripts. Recent studies have shown that posttranscriptional processing precursor miRNAs is induced after DNA damage through regulatory RNA-binding proteins in Drosha Dicer complexes, such as DDX5 KSRP. However, little known about regulation nuclear export pre-miRNAs DNA-damage response, a critical step maturation. Here, we show accelerated an ATM-dependent manner. The ATM-activated AKT kinase...
Chromosome 17q23 amplification occurs in ~11% of human breast cancers. Enriched HER2+ cancers, the is significantly correlated with poor clinical outcomes. In addition to previously identified oncogene WIP1, we uncover an oncogenic microRNA gene, MIR21, a majority WIP1-containing amplicons. The results aberrant expression WIP1 and miR-21, which not only promotes tumorigenesis, but also leads resistance anti-HER2 therapies. Inhibiting miR-21 selectively inhibits proliferation, survival...
Heterozygous deletion of chromosome 17p (17p) is one the most frequent genomic events in human cancers. Beyond tumor suppressor TP53, POLR2A gene encoding catalytic subunit RNA polymerase II (RNAP2) also included a ~20-megabase region 63% metastatic castration-resistant prostate cancer (CRPC). Using focused CRISPR-Cas9 screen, we discovered that heterozygous loss confers selective dependence CRPC cells on ubiquitin E3 ligase Ring-Box 1 (RBX1). RBX1 activates by K63-linked ubiquitination and...
Abstract Most traits of agricultural importance are quantitative controlled by numerous genes. However, it remains unclear about the molecular mechanisms underpinning traits. Here, we report characteristics genes controlling three randomly selected from diverse plant species, including ginsenoside biosynthesis in ginseng ( Panax C.A. Meyer), fiber length cotton Gossypium hirsutum L. and G. barbadense L.) grain yield maize Zea mays L.). We found that a vast majority trait were significantly...
Abstract Background Renal colic is one of the worst types pain in acute renal caused by urinary calculi (ARCUC). We previously proved that acupuncture can alleviate ARCUC patients, but its effect on suspected remains unclear. Objective The objective was to evaluate effectiveness and safety patients with ARCUC. Design This prospective, double-blind, sham acupuncture-controlled, randomized clinical trial conducted from July 2021 June 2024 an emergency department China. Methods immediately...