A5100388702- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Covalent Organic Framework Applications
- Biosensors and Analytical Detection
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Microfluidic and Capillary Electrophoresis Applications
- Nanocluster Synthesis and Applications
- Advanced Proteomics Techniques and Applications
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Spectroscopy and Chemometric Analyses
- Microfluidic and Bio-sensing Technologies
- Nanopore and Nanochannel Transport Studies
- Lipid Membrane Structure and Behavior
- Gold and Silver Nanoparticles Synthesis and Applications
- Conducting polymers and applications
- Analytical chemistry methods development
- Advanced NMR Techniques and Applications
Liaocheng University
2025
Capital Normal University
2016-2024
Southwest Petroleum University
2023
Shandong Normal University
2023
Zhejiang University of Technology
2022
University of Jinan
2022
Liaoning Normal University
2022
Zhejiang A & F University
2022
Chongqing Medical University
2021
Bengbu Medical College
2020
Microfluidic technologies with precise fluid control and rapid microscale mixing have attracted widespread interest in the fabrication engineering of nanomaterials for drug delivery. The drug-loaded prepared by microfluidic methods can exhibit better monodispersity, higher encapsulation efficiency, prolonged blood circulation time as compared to those conventional bench methods. In this review, we summarize recent advances a variety nanomaterials, including organic, inorganic, hybrid...
The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the structure its effect on cell–particle interaction. Here we develop a microfluidic chip allowing synthesis structurally well-defined lipid-polymer same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force...
A hand-powered centrifugal microfluidic platform enables simultaneous detection of pathogenic bacteria within a small disc in an electricity-free manner.
Cherry tomato (Solanum lycopersicum) is popular with consumers over the world due to its special flavor. Soluble solids content (SSC) and firmness are two key metrics for evaluating product qualities. In this work, we develop non-destructive testing techniques SSC fruit based on hyperspectral images corresponding deep learning regression model. Hyperspectral reflectance of 200 fruits derived spectrum ranging from 400 1,000 nm. The acquired corrected spectral information extracted. A novel...
Abstract G-quadruplex (G4)/hemin DNAzyme is promising horseradish peroxidase (HRP)-mimic candidate in the biological field. However, its relatively unsatisfactory catalytic capacity limits potential applications. Inspired by nature protease, we conducted a proximity-enhanced cofactor assembly strategy (PECA) to form an exceptional HRP mimic, namely zippered G4/hemin (Z-G4/H). The hybridization of short oligonucleotides induced proximity DNA-grafted hemin (DGH) with complementary G4 sequences...
A heteroditopic fluoroionophoric platform has been designed for constructing fluorescent probes zinc ions over large concentration ranges. The responses of the prototype 3a and 3b to were shown be consistent with our hypothesis, according which modulation photoinduced electron transfer followed by conformation rigidification or enhanced internal charge a ditopic ligand upon successive coordination affords sensitive fluorescence enhancement in one wavelength channel an emission band shift...
Chromosome 17q23 amplification occurs in ~11% of human breast cancers. Enriched HER2+ cancers, the is significantly correlated with poor clinical outcomes. In addition to previously identified oncogene WIP1, we uncover an oncogenic microRNA gene, MIR21, a majority WIP1-containing amplicons. The results aberrant expression WIP1 and miR-21, which not only promotes tumorigenesis, but also leads resistance anti-HER2 therapies. Inhibiting miR-21 selectively inhibits proliferation, survival...
Herein, a strand displacement amplification (SDA)-assisted CRISPR/Cas12a (LbCpf1) electrochemiluminescence (ECL) biosensor was fabricated for ultrasensitive identification of Staphylococcus aureus (Sa)-16S rDNA. A porphyrinic Zr metal-organic framework (MOF) (PCN-224) nanomaterial prepared as the coreactant accelerator, which promoted conversion S2O82- and SO4*-, thus enhancing reaction with CdS quantum dots (QDs) amplifying ECL emission signal. Meanwhile, presence Sa-16S rDNA, auxiliary...
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) has become a powerful method for studying the spatial distribution of molecules. Preparation tissue sections is critical step obtaining high-quality data. The thickness slice affects feature quality MALDI MSI. However, few studies involved in-depth and systematic examination thickness. Herein, we investigate effect on MSI detection. We found that thicker slice, worse results obtained by MS, which attributed to...
Commercially available dyes of the esculetin and alizarin families are identified as lead structures for constructing ratiometric fluorescent probes zinc ions.
Our previous study demonstrated that 45S ribosomal DNA (45S rDNA) clusters were chromosome fragile sites expressed spontaneously in Lolium. In this study, phenotypes of rDNA observed under aphidicolin (APH) incubation several plant species. Further actinomycin D (ActD) treatment showed transcriptional stress might interfere with chromatin packaging, resulting expression. These data identified as replication-dependent well transcription-dependent plants. the presence ActD, a dramatic switch...
A novel electrochemical cytosensor was developed for the fast and high-sensitivity recognition of drug-resistant leukemia K562/ADM cells based on P-glycoprotein (P-gp) expression level a cell membrane. The nanocomposite interface gold nanoparticles/polyaniline nanofibers (AuNPs/PANI-NF) chosen to design biosensor detection. Au/PANI-NF-based cytosensors coated with anti-P-glycoprotein (anti-P-gp) molecules could provide biomimetic immunosensing surface P-glycoprotein, thus capture...
Photochemically stable fluorescent heteroditopic ligands (9 and 10) for zinc ion were prepared studied. Two independent metal coordination-driven photophysical processes, chelation-enhanced fluorescence (CHEF) internal (or intramolecular) charge transfer (ICT), designed into our ligand framework. This strategy successfully relates three coordination states of a ligand, non-, mono-, dicoordinated, to states, OFF, ON at one wavelength, another wavelength. platform has provided chemical...