Li Wan

ORCID: 0000-0003-2839-2475
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About
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Research Areas
  • Hemodynamic Monitoring and Therapy
  • Sepsis Diagnosis and Treatment
  • Advanced Software Engineering Methodologies
  • Anesthesia and Pain Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Renal function and acid-base balance
  • Cancer Immunotherapy and Biomarkers
  • Viral Infections and Vectors
  • Esophageal Cancer Research and Treatment
  • Software Engineering Research
  • Anesthesia and Sedative Agents
  • Acute Kidney Injury Research
  • Power Systems and Technologies
  • Cardiac Arrest and Resuscitation
  • Smart Grid Energy Management
  • Advanced Battery Technologies Research
  • Virology and Viral Diseases
  • Guidance and Control Systems
  • Musculoskeletal pain and rehabilitation
  • Non-Invasive Vital Sign Monitoring
  • Cardiac Health and Mental Health
  • Ultrasound in Clinical Applications
  • Pediatric Hepatobiliary Diseases and Treatments
  • Industrial Technology and Control Systems
  • Software Engineering Techniques and Practices

Mianyang Central Hospital
2024-2025

University of Electronic Science and Technology of China
2024-2025

Weatherford College
2024

Huaian First People’s Hospital
2015-2024

OriginWater (China)
2024

Union Hospital
2016-2024

Huazhong University of Science and Technology
2014-2023

National Transportation Research Center
2023

Oak Ridge National Laboratory
2023

China University of Mining and Technology
2023

As a special form of noncoding RNAs, circular RNAs (circRNAs) played important roles in regulating cancer progression mainly by functioning as miRNA sponge. While the function RNA-ITCH (cir-ITCH) lung is still less reported, this study, we firstly detected expression cir-ITCH tumor tissues and paired adjacent noncancer 78 patients with using TaqMan-based quantitative real-time PCR (qRT-PCR). The results showed that was significantly decreased tissues. In cellular studies, also enhanced...

10.1155/2016/1579490 article EN cc-by BioMed Research International 2016-01-01

10.1007/s11010-013-1959-1 article EN Molecular and Cellular Biochemistry 2014-01-04

Abstract Background The lack of knowledge regarding the pathogenesis and host immune response during SARS-CoV-2 infection has limited development effective treatments. Thus, we longitudinally investigated dynamic changes in peripheral blood lymphocyte subsets parallel cytokine levels COVID-19 patients with different disease severities to further address pathogenesis. Methods A total 67 (10 moderate, 38 severe 19 critical cases) admitted a tertiary care hospital Wuhan from February 8th April...

10.1186/s12879-021-05792-7 article EN cc-by BMC Infectious Diseases 2021-01-18

Comprehensive antitumor therapy through integrated multimodal means has drawn increasing attention owing to its high efficiency and metastasis suppression.We describe a synergistic triple protocol combining photothermal sonodynamic (PTT SDT), together with immune checkpoint blockade for the inhibition of breast cancer growth metastases in 4T1 mouse model. PTT SDT are synergistically augmented by novel imaging nanoprobe cell membrane-biomimetic nanoparticles (CHINPs) loaded superparamagnetic...

10.1186/s12951-022-01287-y article EN cc-by Journal of Nanobiotechnology 2022-02-15

The purpose of the present study was to measure incidence and outcome septic patients presenting at emergency department (ED) with criteria for early goal-directed therapy (EGDT). This hospital-based, retrospective, observational using prospectively collected electronic databases based in a teaching hospital Melbourne, Australia. We conducted outcome-blinded screening infection admitted via ED from 1 January 2000 30 June 2003. obtained data on demographics, laboratory clinical features...

10.1186/cc4918 article EN cc-by Critical Care 2006-01-01

<i >Background</i>. The pulmonary artery catheter (PAC) is an accepted clinical method of measuring cardiac output (CO) despite no prior validation. ultrasonic monitor (USCOM) a noninvasive alternative to PAC using Doppler ultrasound (CW). We compared and USCOM CO measurements against gold standard, the aortic flow probe (FP), in sheep at varying outputs. >Methods</i>. Ten conscious sheep, with implanted FPs, had by FP, USCOM, PAC, rest during intervention inotropes vasopressors....

10.1155/2012/621496 article EN cc-by Critical Care Research and Practice 2012-01-01

Robotic surgery is a cutting-edge minimally invasive technique that overcomes many shortcomings of laparoscopic techniques, yet few studies have evaluated the use robotic to treat Hirschsprung's disease (HSCR).To analyze feasibility and medium-term outcomes robotic-assisted proctosigmoidectomy (RAPS) with sphincter- nerve-sparing in HSCR patients.From July 2015 January 2022, 156 rectosigmoid patients were enrolled this multicenter prospective study. Their sphincters nerves spared by...

10.3748/wjg.v29.i23.3715 article EN cc-by-nc World Journal of Gastroenterology 2023-06-16

Background and Aims Although terlipressin (TP) may improve renal function in cirrhotic patients, its use sepsis remains controversial due to concerns about regional ischemia. We investigated the effects of TP on hemodynamics kidney experimental hyperdynamic sepsis. Methods studied thirteen merino ewes a university physiology laboratory using randomized controlled cross over design. implanted flow probes around pulmonary, circumflex coronary, superior mesenteric, iliac arteries. injected live...

10.1371/journal.pone.0029693 article EN cc-by PLoS ONE 2012-02-15

10.1016/j.trd.2023.103943 article EN Transportation Research Part D Transport and Environment 2023-10-26

DNA damage repair genes JWA, XRCC1 and BRCA1 were associated with clinical outcomes could convert the response to cisplatin-based therapy in some carcinomas. The synergistic effects of mRNA expression on personalized remain unknown advanced esophageal squamous cell carcinoma (ESCC).We employed quantitative real-time polymerase chain reaction (qPCR) determine paraffin-embedded specimen from 172 patients ESCC who underwent first-line cisplatin-or docetaxel-based treatments.High JWA or...

10.1186/s12885-015-1364-0 article EN cc-by BMC Cancer 2015-04-29

<h3>Background and Objectives</h3> The medical community commonly uses lipid emulsion combined with epinephrine in local anesthetic–induced cardiac arrest, but the optimal timing of administration relative to is currently unknown needs be determined. <h3>Methods</h3> Thirty adult male Sprague-Dawley rats were subjected bupivacaine-induced asystole then randomly divided into 3 groups. temporal varied each group: (1) immediately after completion initial bolus therapy (postILE0); (2) arrest...

10.1097/aap.0000000000000220 article EN Regional Anesthesia & Pain Medicine 2015-01-01

To assess the relationship between PiCCO-derived signals and conventional measures of pre-load gas exchange in patients with septic shock.Prospective observational study 23 shock. Scheduled collection clinical, haemodynamic PiCCO derived variables. Statistical analysis correlations.Patients had a mean SAPS II score 53.5 +/- 14.5 78.3% on mechanical ventilation at insertion. monitoring lasted 4.3 2.9 days. predicted 28-day mortality was 54.2%, while actual 39.1%. At insertion, there an...

10.1016/s1441-2772(23)02036-7 article EN cc-by-nc-nd Critical Care and Resuscitation 2005-09-01

BACKGROUND:The aim of the present study was to evaluate prognosis among patients with a single large hepatocellular carcinoma (HCC) >5 cm compared other in Barcelona Clinic Liver Cancer (BCLC) stage A or B. MATERIAL AND METHODS:Data on BCLC A/B HCC were collected between 2008 and 2012. subclassified as A1 (single tumor, 2-5 cm, 2-3 nodules £3 cm), A2 tumor cm). Overall survival (OS) evaluated compared. RESULTS:Among 1005 HCC, 455 A1, 188 A2, 362 The OS significantly worse than that (median...

10.12659/msm.926797 article EN Medical Science Monitor 2020-10-16
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