A5054964974- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Lung Cancer Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Pneumonia and Respiratory Infections
- Pulmonary Hypertension Research and Treatments
- Inhalation and Respiratory Drug Delivery
- Pneumothorax, Barotrauma, Emphysema
- Congenital Diaphragmatic Hernia Studies
- Pediatric health and respiratory diseases
- Medical Imaging and Pathology Studies
- Immune Response and Inflammation
- Trauma Management and Diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tuberculosis Research and Epidemiology
- Ion Transport and Channel Regulation
- Hematological disorders and diagnostics
- Systemic Lupus Erythematosus Research
- Airway Management and Intubation Techniques
- Lung Cancer Treatments and Mutations
Sun Yat-sen University
2012-2024
Emory University
2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
The First Affiliated Hospital, Sun Yat-sen University
2009-2021
Bridge University
2020
Zero to Three
2017
Guangxi Medical University
2013
Shanxi Medical University
2012
China Postdoctoral Science Foundation
2007
Research Institute for Farm Animal Biology (FBN)
1999
Patients with mild or moderate chronic obstructive pulmonary disease (COPD) rarely receive medications, because they have few symptoms. We hypothesized that long-term use of tiotropium would improve lung function and ameliorate the decline in patients COPD.
Objectives: The purpose of this retrospective study was to identify factors associated with recurrent spontaneous pneumothorax (SP) in southern China, and compare the therapeutic effectiveness different procedures. Methods: A total 182 consecutive patients (89.0% male; mean age, 38.9 years), admitted their first episode pneumothorax, were reviewed retrospectively. Follow up available 138 (75.8%), including 68 treated by chemical pleurodesis 70 chest tube drainage alone. cumulative recurrence...
Sirtuin6 (SIRT6), a member of the sirtuins protein family, plays multiple complex roles in cancer. Here, we report that elevated SIRT6 expression was correlated with clinicopathological parameters such as T and N classification non-small cell lung cancer (NSCLC) patient tumors. overexpression NSCLC lines increased extracellular signal-regulated kinase (p-ERK)1/2 phosphorylation, activated matrix metalloproteinase 9 (MMP9) promoted tumor migration invasion. Upon treatment specific...
Abstract Background The lack of knowledge regarding the pathogenesis and host immune response during SARS-CoV-2 infection has limited development effective treatments. Thus, we longitudinally investigated dynamic changes in peripheral blood lymphocyte subsets parallel cytokine levels COVID-19 patients with different disease severities to further address pathogenesis. Methods A total 67 (10 moderate, 38 severe 19 critical cases) admitted a tertiary care hospital Wuhan from February 8th April...
Fractional exhaled nitric oxide (FeNO) is an easy, sensitive, reproducible, and noninvasive marker of eosinophilic airway inflammation. Accordingly, FeNO extensively used to diagnose manage asthma. Patients with COPD who share some the features asthma have a condition called asthma-COPD overlap syndrome (ACOS). The feasibility using differentiate ACOS patients from remains unclear.From February 2013 May 2016, suspected through physician's opinion were subjected measurement, pulmonary...
Chronic obstructive pulmonary disease (COPD) is an independent risk factor for lung cancer development, but the mechanism not fully understood. Muscarinic receptor 3 (M3R) has been found to be involved in progression of small-cell and pathological process COPD. We hypothesized that M3R may contribute especially patients with COPD.The correlation between expression clinical features non-small-cell (NSCLC) was evaluated 148 paraffin-embedded archived NSCLC specimens use immunohistochemistry....
Abstract Background and objective Triple combination therapy with tiotropium plus budesonide/formoterol has improved lung function reduced exacerbation risk in patients chronic obstructive pulmonary disease ( COPD ) Western countries, but no such data exist for E ast A sian patients. This study aimed to evaluate the efficacy tolerability of adding compared alone severe/very severe . Methods 12‐week, randomized, parallel‐group, multicentre, open‐label was conducted sia. After a 14‐day run‐in...
Corticosteroids can inhibit the inflammatory process and formation of fibrosis. The purpose this study was to determine whether concurrent use steroids at time talc-slurry pleurodesis would influence development pleurodesis. One group rabbits received an intrapleural injection talc (400 mg/kg) intramuscular triamcinolone (0.8 1 d before instillation weekly thereafter, whereas a control only talc. Ten in each were killed 6 h 1, 2, 4, 7, 14, 28 after instillation. mean volume pleural fluid...
To investigate the clinical features, management, and prognosis of pulmonary cryptococcosis in non-acquired immunodeficiency syndrome (AIDS) patients. 24 cases with accurate pathological diagnosis were retrospectively studied. 15 male patients nine female diagnosed at first affiliated hospital Sun Yat-sen University from November 1999 to 2011. The mean age time was 44.2 ± 11.3 years (range: 65 years). Among these patients, 13 had other comorbidities. symptomatic asymptomatic. most common...
Background: Asthma affects a large number of patients in China, but relatively little is known about asthma management among Chinese patients. This study aims to estimate control rate adult and identify predictors associated with uncontrolled asthma. Methods: A total 4125 aged ⩾17 years representing all regions mainland China except Tibet were surveyed. status was assessed using the Control Test (ACT) classified as controlled (ACT score ⩾ 20) ⩽ 19). multivariate logistic regression model...
To analyze the characteristics of tuberculosis (TB) in Southern Chinese renal transplant recipients, and summarize corresponding experiences diagnosis management.Retrospectively study 41 documented post-transplant TB cases out 2333 patients who received kidney transplantation First Affiliated Hospital Sun Yat-sen University between Jan. 1991 Apr. 2007.TB post-renal-transplant population China displayed following characteristics: (i) high incidence within a short time after transplantation,...
Abstract Background Bostrycin is a novel compound isolated from marine fungi that inhibits proliferation of many cancer cells. However, the inhibitory effect bostrycin on lung cancers has not been reported. This study to investigate effects and mechanism human cells in vitro. Methods We used MTT assay, flow cytometry, microarray, real time PCR, Western blotting detect A549 pulmonary adenocarcinoma Results showed significant inhibition cell induction apoptosis bostrycin-treated treatment...
Drug resistant Mycoplasma pneumoniae (MP) is a rising issue in the management of community-acquired pneumonia (CAP). Epidemiological monitoring essential for identifying patterns MP isolates against various antibiotics adult CAP patients.This prospectively designed multicenter study conducted on patients with visiting six teaching hospitals cities Beijing, Shanghai and Guangzhou between September 2010 June 2012.A total 520 (mean age: 45.7±26.2 years) were included. Of patients, only 75...
Invasive mucinous adenocarcinoma (IMA) is a variant of lung with several growth patterns, such as lepidic acinar and papillary. However, to our knowledge, no study regarding prognostic clinicopathologic aspects IMAs different patterns has been reported. Of 2,236 patients primary adenocarcinoma, 16 were identified having lepidic-predominant IMA 10 acinar-predominant IMA. Data the characteristics, computed tomography (CT) features, prognosis collected. No statistically significant difference...
Macrophage migration inhibitory factor (MIF) inhibition can attenuate pulmonary fibrosis, but the antifibrotic mechanism is unclear. Here we investigated effect of MIF knockdown in rats with bleomycin (BLM)-induced fibrosis. The results showed that attenuated lung injury and extracellular matrix deposition; significantly reduced levels cytokines including transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17), hydroxyproline (hyp), fibroblast 23...
Introduction . Since the NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B pathway regulates both inflammation and host defense, it is uncertain whether interventions targeting id="M3"><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B would be beneficial in sepsis. Based on kinetics of innate immune response, we postulated that selective id="M4"><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B inhibition during a...
Fractional exhaled nitric oxide (FeNO) measurement is a simple, rapid, highly reproducible, and noninvasive method of airway inflammation assessment. Therefore, FeNO extensively used for the diagnosis management asthma. The feasibility using as an alternative to conventional pulmonary function test differentiate patients with bronchiectasis (BE) bronchial asthma from those BE only remains unclear.From February 2013 2015, 99 diagnosed through high-resolution computed tomography (HRCT) were...
Objective: Fractional exhaled nitric oxide (FeNO) is a non-invasive method used to reveal the eosinophilic inflammation of airway and diagnose manage asthma. The use FeNO measurement or its combination with small function in differentiating CVA patients from chronic cough unexplored. Methods: From December 2012 June 2016, non-productive for more than 8 weeks based on physician's opinion were subjected FeNO, pulmonary function, bronchial hyperresponsiveness (BHR) tests. Receiver operating...