A5021205870- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Advanced Breast Cancer Therapies
- Pleural and Pulmonary Diseases
- Colorectal Cancer Treatments and Studies
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Colorectal and Anal Carcinomas
- Venous Thromboembolism Diagnosis and Management
- Heme Oxygenase-1 and Carbon Monoxide
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Research Studies
- Tuberculosis Research and Epidemiology
- Effects of Radiation Exposure
- Colorectal Cancer Surgical Treatments
- Lung Cancer Diagnosis and Treatment
- Amoebic Infections and Treatments
- Inhalation and Respiratory Drug Delivery
- Organ Transplantation Techniques and Outcomes
- Advanced Biosensing Techniques and Applications
- Family and Patient Care in Intensive Care Units
- COVID-19 Impact on Reproduction
Sun Yat-sen University
2013-2024
The First Affiliated Hospital, Sun Yat-sen University
2013-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2021
Huazhong University of Science and Technology
2020
Wuhan Union Hospital
2020
The interaction between CD155 and its high-affinity ligand TIGIT is being increasingly investigated in various solid tumors. However, the prognostic significance of lung adenocarcinoma (LUAD) remains unclear. In this study, immunohistochemistry was applied 334 LUAD cases to evaluate expression TIGIT. Western blotting conducted 5 paired primary adjacent normal tissues. Our results reveal that are overexpressed tissues aberrant overexpression closely correlated with poor clinical outcomes (P <...
Abstract Background The lack of knowledge regarding the pathogenesis and host immune response during SARS-CoV-2 infection has limited development effective treatments. Thus, we longitudinally investigated dynamic changes in peripheral blood lymphocyte subsets parallel cytokine levels COVID-19 patients with different disease severities to further address pathogenesis. Methods A total 67 (10 moderate, 38 severe 19 critical cases) admitted a tertiary care hospital Wuhan from February 8th April...
Macrophage migration inhibitory factor (MIF) inhibition can attenuate pulmonary fibrosis, but the antifibrotic mechanism is unclear. Here we investigated effect of MIF knockdown in rats with bleomycin (BLM)-induced fibrosis. The results showed that attenuated lung injury and extracellular matrix deposition; significantly reduced levels cytokines including transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17), hydroxyproline (hyp), fibroblast 23...
Precise detection of anaplastic lymphoma kinase (ALK) rearrangement guides the application ALK-targeted tyrosine inhibitors (ALK-TKIs) in patients with non-small-cell lung cancer (NSCLC). Next-generation sequencing (NGS) has been widely used clinics, but DNA-based NGS to detect fusion genes delivered false-negative results. However, can be successfully detected at transcription level and higher sensitivity using RNA-based reverse polymerase chain reaction (RT-PCR). This study compared...
Targeted next-generation sequencing (tNGS) has become a trending tool in the field of infection diagnosis, but concerns are also raising about its performance compared with metagenomic (mNGS). This study aims to explore clinical feasibility tNGS panel for respiratory tract diagnosis and compare it mNGS same cohort inpatients.
A large number of EGFR mutant non-small cell lung cancer patients primordially benefit from first-line treatment with first-generation EGFR-tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. However, multiple acquired resistance mechanisms have been described that limit the clinical efficacy EGFR-TKIs. Herein, we report a rare case adenocarcinoma harboring an exon 19-deletion mutation before administration target therapy. This patient to EGFR-TKIs through small (SCLC)...
Bronchoscopies are extensively adopted for diagnosing and staging thoracic malignancies, but studies missing as how to keep the process streamlined more efficient. To evaluate current role of bronchoalveolar lavage (BAL) cancer possible infection diagnosis when practicing comprehensive bronchoscopy patients suspected with malignancy, provide foundation practice modification.We retrospectively analyzed a prospectively kept database immunocompetent undergoing non-hematologic malignancies....
Abstract Stage III non‐small cell lung cancer (NSCLC) encompasses a group of diseases with high heterogeneity. Such patients should actively receive comprehensive treatments. It is imperative for all stage NSCLC to consultation multiple disciplinary team, which allows the development proposal clinical diagnosis and treatment. In this consensus, divided into two types (operable inoperable) according different conditions. Resectable further subdivided conditions (with or without driver genes)....
In patients with refractory pleural effusion or pneumothorax, fever and elevated level of white blood cell count (WBC) are frequently observed after chemical pleurodesis intrapleural injection OK-432, which make it difficult to differentiate whether was from the side effects OK-432 concurrent bacterial infection.Procalcitonin (PCT) levels were measured before so as discuss PCT is useful for distinguishing between infection.Twenty-six pneumothorax who underwent at First Affiliated Hospital...
Abstract: Osimertinib has efficacy superior to that of standard epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) for the first-line treatment patients with EGFR-mutant advanced non-small cell lung cancer (NSCLC). However, treated osimertinib eventually acquire drug resistance. MET missense mutations have been demonstrated mediate resistance MET-TKIs, such as crizotinib. But role in mediating EGFR TKI is undefined. With increasing use next-generation sequencing (NGS)...
Objective: To investigate the effect of irradiation to anastomosis from preoperative radiotherapy for patients with rectal cancer by studying pathological changes. Methods: In this retrospective study, enrolled in FOWARC study January 2011 July 2014 Sixth Affiliated Hospital Sun Yat-Sen University were included. local advanced randomly assigned receive either neoadjuvant chemo-radiotherapy or chemotherapy. Among these patients, 23 selected as radiation proctitis (RP)group, who fulfilled...
Importance: Checkpoint inhibitor pneumonitis (CIP) is a rare but serious adverse event that may impact treatment decisions. However, there limited information comparing CIP risks between immune checkpoint (ICI) monotherapy and combination with chemotherapy due to lack of direct cross-comparison in clinical trials. Objective: To determine whether ICI superior other drug regimens (including monotherapy) terms risk. Study Design Methods: This observational, cross-sectional worldwide...
Toll-like receptor (TLR) 7 is an important mediator in inflammation. However, its role hyperoxia-induced acute lung injury (HALI) remains to be elucidated. C57BL/6 wild-type and background TLR deficiency mice were exposed hyperoxia stimulate HALI airtight cages. Animals sacrificed at 72 h post or room air exposure. Lung indicators measured. Moreover, soluble epoxide hydrolase (sEH) activity was detected by a 14, 15-EET/DHET ELISA kit. Activation of activator protein (AP)-1 nuclear factor...
Abstract Bioluminogenic probes emerged as powerful tools for imaging and analysis of various bioanalyses, but traditional approaches would be limited to the low sensitivity during determine activity protease in clinical specimens. Herein, we proposed a caged luciferase inhibitor‐based bioluminescence‐switching strategy (CLIBS) by using cleavable inhibitor modulate reporter amplify detective signals, which led enhancement detection sensitivity, enabled determination circulating Aminopeptidase...
Negative conversion of nucleic acid was a key factor in deciding discharge or the end isolation asymptomatic mild COVID-19 patients. We aimed to explore effect vaccination on time negative after Omicron infection.This retrospective cohort study included patients with admitted Fangcang shelter Hospital from November 10, 2022 December 2, 2022. The relationship between status and analyzed by multiple linear regression.A total 2,104 were analysis, whom 1,963 vaccinated. mean no vaccination, one...
Objective: To explore clinical features and prognosis of anastomotic leak (AL) after anterior resection following neoadjuvant chemoradiotherapy for rectal cancer patients. Methods: A retrospective cohort study was performed. Data were retrieved from colorectal database the Sixth Affiliated Hospital, Sun Yat-sen University. The data 470 patients with who underwent at our department September 2010 to December 2018 enrolled. Clinical outcome postoperative AL analyzed. primary outcomes...
Abstract Background Kodamaea ohmeri is a rare pathogen with high mortality and found among blood samples in considerable proportion; however, gastrointestinal infection of K. extremely rare. Invasive pulmonary aspergillosis also an uncommon fungal; these two fungal infections reported concomitantly are unprecedented. Case presentation We described case 37-year-old male who got infected invasive aspergillosis. used the mass spectrometry histopathology to identify separately. For treatment ,...
Objective: To investigate the safety and efficacy of surgical treatment for chronic radiation intestinal injury. Methods: A descriptive cohort study was performed. Clinical data 73 patients with definite history diagnosed clinically as injury, undergoing operation at Department Colorectal Surgery, Sixth Affiliated Hospital Sun Yat-sen University from January 1, 2012 to February 28, 2019, were reviewed analyzed retrospectively. Patients did not undergo or only received adhesiolysis excluded....
Abstract Background: The number of deaths caused by COVID-19 are on the rising worldwide. This study focused severe and critically ill COVID-19, aim to explore independent risk factors associated with disease severity build a nomogram predict patients’ prognosis. Methods: Patients laboratory-confirmed admitted Union Hospital, Tongji Medical College Hankou Hospital Wuhan, China, from February 8th April 6th, 2020. LASSO Regression Multivariate Analysis were applied screen factors. COX Nomogram...