A5005085624- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Immune cells in cancer
- Immune Cell Function and Interaction
- Medical Imaging Techniques and Applications
- Cancer-related gene regulation
- Head and Neck Cancer Studies
- Tryptophan and brain disorders
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Metabolomics and Mass Spectrometry Studies
Qidong Liver Cancer Prevention Research
2025
Southern Medical University
2015-2024
Zhujiang Hospital
2020-2023
Sichuan University
2020-2023
West China Hospital of Sichuan University
2023
Ningbo University
2022-2023
Yixing People's Hospital
2022
Jiangsu University
2022
Shanxi Medical University
2021
Nanfang Hospital
2009-2020
Cancer associated fibroblasts (CAFs) are key stroma cells that play dominant roles in tumor progression. However, the CAFs-derived molecular determinants regulate colorectal cancer (CRC) metastasis and chemoresistance have not been fully characterized. CAFs NFs were obtained from fresh CRC adjacent normal tissues. Exosomes isolated conditioned medium serum of patients using ultracentrifugation method ExoQuick Exosome Precipitation Solution kit, characterized by transmission electronic...
Use of artificial intelligence to identify dermoscopic images has brought major breakthroughs in recent years the early diagnosis and treatment skin cancer, incidence which is increasing year by worldwide poses a great threat human health. Achievements have been made research cancer image classification using deep backbone convolutional neural network (CNN). This approach, however, only extracts features small objects image, cannot locate important parts.As result, researchers paper turn...
Upregulation of matrix metalloproteinase MMP-14 (MT1-MMP) is associated with poor prognosis in cancer patients, but it unclear how becomes elevated tumors. Here, we show that miR-181a-5p downregulated aggressive human breast and colon cancers where its levels correlate inversely expression. In clinical specimens, enhanced expression was observed cells located at the invasive front tumors relative to adjacent normal cells. Bioinformatics analyses defined a potential response element within...
Oral mucositis is probably the most debilitating complication that can arise in treating a patient with head and neck cancer. Little known about impacts of oral microbiota on initiation progression mucositis.Based 16S rRNA gene sequencing, dynamic changes bacterial profile as well correlations between severity shifts during radiotherapy were investigated.Our results revealed community structure altered progressively radiation therapy, parallel marked increase relative abundance some...
Abstract To develop a deep learning system based on 3D convolutional neural networks (CNNs), and to automatically predict EGFR‐mutant pulmonary adenocarcinoma in CT images. A dataset of 579 nodules with EGFR mutation status labels mutant (Mut) or wild‐type (WT) was retrospectively analyzed. system, namely DenseNets, developed process patches from data, learn strong representations supervised end‐to‐end training. The DenseNets were trained training subset 348 tuned development 116 nodules....
Esophageal adenocarcinoma ranks sixth in cancer mortality the world and its incidence has risen dramatically Western population over last decades. Data presented herein strongly suggest that Notch signaling is critical for esophageal underlies resistance to chemotherapy. We present evidence drives a stem cell phenotype by regulating genes establish stemness. Using patient-derived xenograft models, we demonstrate inhibition of gamma-secretase inhibitors (GSI) efficacious downsizing tumor...
Abstract In many cancers, aberrant Notch activity has been demonstrated to play a role in the initiation and maintenance of neoplastic phenotype cancer stem cells, which may allude its additional involvement metastasis resistance therapy. Therefore, is an exceedingly attractive therapeutic target cancer, but full range potential targets within pathway underexplored. To date, there are no small-molecule inhibitors that directly intracellular or assembly transcriptional activation complex....
Background: We performed a meta-analysis to compare overall survival (OS) outcomes in patients with synchronous oligometastatic non-small cell lung cancer (NSCLC) who underwent aggressive thoracic therapy (ATT) those did not. Methods: A systematic review of controlled trials ATT on NSCLC was conducted. Hazard ratio (HR) for the main endpoint OS pooled using fixed-effects model. Subgroup analysis single organ metastases, or different numbers brain stages disease. Pooled curves were...
// Yuan Fang 1, * , Xiaoxia Zhu Jian Wang Na Li 1 Dianhe Nazmus Sakib Zhou Sha Wen Song Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China These authors have contributed equally to this work Correspondence to: Zhu, e-mail: zhuxx01@126.com Keywords: miR-744, nasopharyngeal carcinoma, ARHGAP5, tumorigenesis, metastasis Received: October 24, 2014 Accepted: April 6, 2015 Published: 18, ABSTRACT Nasopharyngeal carcinoma (NPC) is a highly invasive and...
The prognostic factors of oligometastatic non-small cell lung cancer (NSCLC) are uncertain. We performed a meta-analysis to assess the NSCLC patients who most likely achieve long-term survival.We searched PubMed, EMBASE, Cochrane identify eligible articles and all randomized controlled trials (RCTs) retrospective comparative studies revealing NSCLC. primary endpoint interest was overall survival (OS).We analyzed data from twenty-four studies, including 1,935 with In univariate analysis, we...
Abstract Background The metastasis-associated gene 1 (MTA1) has been identified as one critical regulator of tumor metastasis. Previously, we miR-125b a downregualted miRNA in non-small cell lung cancer (NSCLC) line upon MTA1 depletion. However, the role and regulation NSCLC metastasis remains unclear. Methods Stable knockdown lines 95D SPC-A-1 were established by transfection with shRNA. effects depletion on expression migration invasion examined real-time PCR, wound healing matrigel assay....
Metastasis-associated gene 1 (MTA1) is associated with cell growth, metastasis, and survival in non-small-cell lung cancer (NSCLC). Several previous reports have demonstrated that microRNAs affect expression through interaction between their seed region the 3'-untranslated of target mRNA, resulting post-transcriptional regulation. The aim this study was to identify miRNAs suppress malignancy NSCLC cells by targeting MTA1. Two human lines were analyzed for MTA1 quantitative RT-PCR western...
Abstract The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. response initiated is highly cell context dependent, indicating that multiple factors influence target gene selection and activity. However, the mechanism which drives transcription not well understood. Herein, we identify characterize a novel Notch-interacting protein, activation complex kinase (NACK), acts as coactivator. We show NACK associates with on DNA, mediates...
Xiao Yao San (XYS) is a classical Chinese medicine formula that has been widely used to treat mood disorders for hundreds of years. To confirm the effect XYS and better understand its underlying mechanism, high-performance liquid chromatography-mass spectrometry analysis-based quality control extracts proteomics-based identification differential proteins in hippocampus were adopted social isolation chronic unpredictable mild stress- (CUMS-) treated rats. The depressive-like behavior rats...
Aims/Background Medullary thyroid carcinoma (MTC) is a rare malignancy with high mortality rate. Early detection of cervical lymph node metastasis (LNM) critical for improving prognosis patients MTC. This study aimed to investigate the predictive utility ultrasound-based radiomics preoperative prediction LNM in MTC patients. Methods The clinical, ultrasound, and pathological information 193 were retrospectively examined. Radiomics features obtained from ultrasound images using PyRadiomics....
MicroRNAs (miRNAs) are important regulators in the process of cardiac hypertrophy and heart failure. Previous studies have shown that miR-199a is upregulated pressure-overload inhibition attenuates vitro. However, therapeutic role anti-miR-199a treatment vivo model less known. Here, we show an efficient useful method to treat mouse restore function through injection adeno-associated virus (AAV)-mediated tough decoys (TuDs). RNA-seq transcriptome analysis indicated genes related cytoplasmic...
Non-small cell lung cancer (NSCLC) accounts for about 85% of cancers. This study aimed to discover the potential miRNA biomarkers early detection NSCLC.Total circulating miRNAs were extracted from six patients and volunteers run on chip. The differentially expressed acquired by data mining intersected with chip results, qRT-PCR carried out. Then validated using a validation cohort (120 participants). ROC curves established evaluate diagnostic efficacy miRNAs. target genes differential...