A5012008900- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Parasite Biology and Host Interactions
- Macrophage Migration Inhibitory Factor
- Electrospun Nanofibers in Biomedical Applications
- Amoebic Infections and Treatments
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Mitochondrial Function and Pathology
- Natural product bioactivities and synthesis
- Gut microbiota and health
- ATP Synthase and ATPases Research
- Wound Healing and Treatments
- Nanoparticle-Based Drug Delivery
- Autophagy in Disease and Therapy
- Biochemical and Molecular Research
- Polysaccharides and Plant Cell Walls
- Ubiquitin and proteasome pathways
- Nanomaterials for catalytic reactions
- Photoacoustic and Ultrasonic Imaging
- Probiotics and Fermented Foods
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Innovative Microfluidic and Catalytic Techniques Innovation
Donghua University
2020-2025
Chongqing University
2025
Ministry of Agriculture and Rural Affairs
2025
China Animal Health and Epidemiology Center
2025
Qingdao University
2023-2025
Affiliated Hospital of Qingdao University
2023-2025
Pennsylvania State University
2021-2024
Children's Hospital of Zhejiang University
2020-2024
Zhejiang University of Science and Technology
2024
Shandong Provincial Hospital
2024
Abstract Although accumulating evidence has linked mesenchymal stem cells (MSCs) with tumor growth, the underlying mechanisms are poorly understood. Here, we demonstrated for first time that human umbilical cord MSCs (hUCMSCs) dramatically increased growth of lung adenocarcinoma (LUAD) cancer in a xenograft model. Then, observed hUCMSC-derived extracellular vesicles (hUCMSC-EVs) contribute to hUCMSC-promoted LUAD cell through direct effect on cells. Furthermore, showed hUCMSC-EV-mediated is...
Vascularization and bone regeneration are two closely related processes during reconstruction. A three-dimensional (3D) scaffold with porous architecture provides a suitable microenvironment for vascular growth formation. Here, we present simple general strategy to construct nanofibrous poly(l-lactide)/poly(ε-caprolactone) (PLLA/PCL) interconnected perfusable microchannel networks (IPMs) based on 3D printing technology by combining the phase separation sacrificial template methods. The...
Aquaporin-4 (AQP4) is highly expressed in mammalian brains and involved the pathophysiology of cerebral disorders, including stroke, tumors, infections, hydrocephalus, epilepsy, traumatic brain injury. We found that AQP4-deficient mice were hypersensitive to stimulations such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or lipopolysaccharide compared wild-type (WT) littermates. In a mouse model MPTP-induced Parkinson's disease (PD), animals show more robust microglial inflammatory...
Schistosome eggs are trapped in host liver and elicit severe hepatic granulomatous inflammation, which can lead to periportal fibrosis, portal hypertension, hemorrhage, or even death the host. It was reported that macrophage plays an important role immune responses schistosome infection. Nitric oxide (NO) produced by classically activated macrophages (M1 macrophages) is cytotoxic schistosomula prevent schistosomal while arginase-1 (Arg-1) expressed alternatively (M2 promotes fibrosis....
// Yuan Fang 1, * , Xiaoxia Zhu Jian Wang Na Li 1 Dianhe Nazmus Sakib Zhou Sha Wen Song Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China These authors have contributed equally to this work Correspondence to: Zhu, e-mail: zhuxx01@126.com Keywords: miR-744, nasopharyngeal carcinoma, ARHGAP5, tumorigenesis, metastasis Received: October 24, 2014 Accepted: April 6, 2015 Published: 18, ABSTRACT Nasopharyngeal carcinoma (NPC) is a highly invasive and...
The as-prepared nanoparticles integrate bone targeted chem-chemodynamic combination therapy and dual-modality computed tomography/magnetic resonance (CT/MR) imaging into a single platform.
Abstract Chronic schistosome infection results in the suppression of host immune responses, allowing long‐term survival and restricting pathology. Current theories suggest that Treg play an important role this regulation. However, mechanism induction during is still unknown. The aim study was to determine behind CD4 + CD25 T cells by Schistosoma japonicum HSP60 (SjHSP60)‐derived peptide SJMHE1 as well elucidate cellular molecular basis for S. infection. Mice immunized with or spleen LN from...
In this study, we advance our understanding of the spatial relationship between purinosome, a liquid condensate consisting six enzymes involved in de novo purine biosynthesis, and mitochondria. Previous research has shown that purinosomes move along tubulin toward mitochondria, suggesting direct uptake glycine from Here, propose purinosome is located proximally to mitochondrial transporters SLC25A13 SLC25A38, facilitating glycine, aspartate, glutamate, essential factors for synthesis. We...
Metastasis-associated gene 1 (MTA1) is associated with cell growth, metastasis, and survival in non-small-cell lung cancer (NSCLC). Several previous reports have demonstrated that microRNAs affect expression through interaction between their seed region the 3'-untranslated of target mRNA, resulting post-transcriptional regulation. The aim this study was to identify miRNAs suppress malignancy NSCLC cells by targeting MTA1. Two human lines were analyzed for MTA1 quantitative RT-PCR western...
Cyclodextrin (CD)-capped mesoporous silica nanoparticles (MSN) with pH-responsive properties were synthesized, but little research has been carried out to evaluate the impact of critical factors such as stalk density and type CD on release behavior. Here, effect different densities behavior was investigated. Either too low or high grafted p-anisidine could result in poor cargo release, optimum for MSN measured by thermal analysis, found be approximately 8.7 stalks nm−2. To achieve effective...
The stability of the intestinal microenvironment is basis for maintaining normal physiological activities intestine.
Exhaustion of the immune system's ability to adapt novelty suggests that changes it undergoes might be a consequence an evolutionary unpredictable antigenic exposure over lifetime. Thus, we raise question whether naive system can manage new antigens better than educated system. Here, by employing germ-free (GF) mice without history microbial exposure, compared their adaptive responses with those conventional (Conv) upon viral infection. Interestingly, GF showed robust T-cell responses, more...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious that poses significant threat to the global pig farming industry, resulting in substantial economic losses. However, owing high variability of PRRSV unclear mechanisms infection, there are currently no effective vaccines or drugs available for its prevention control. Our previous report revealed pathogenic (HP-PRRSV) requires FAK-PI3K-AKT signaling pathway facilitate entry into cells. In this study, we further...
Abstract Agrobacterium tumefaciens has the unique ability to mediate inter-kingdom DNA transfer, and for this reason, it been utilized plant genetic engineering. To increase transformation frequency in engineering, we focused on gamma-aminobutyric acid (GABA), which is a negative factor -plant interaction. Recent studies have shown contradictory results regarding effects of GABA vir gene expression, leading speculation that inhibits T-DNA transfer. In study, examined effect transfer using...
Background Parasitic helminths need to suppress the host immune system establish chronic infections. Paradoxically, immunosuppression induced by worm also benefits limiting excessive inflammation and tissue damage, which remains major cause leading serious morbidity mortality. Regulatory T cells (Tregs) are key regulators of this mutualism. The successive rise in Tregs during schistosome infection plays a critical role immunoregulation. We others previously showed that Schistosoma japonicum...
A periplasmic catalase has been purified and cloned from Brucella abortus. The functional enzyme is a tetramer with subunit molecular weight of 55,000. All evidence indicates that typical N-terminal signal sequence not associated the export this protein to periplasm.
Toll-like receptor (TLR) ligands have been explored as vaccine adjuvants for tumor and virus immunotherapy, but few TLR affecting schistosoma vaccines characterized. Previously, we developed a partially protective DNA encoding the 26-kDa glutathione S-transferase of Schistosoma japonicum (pVAX1-Sj26GST).In this study, evaluated TLR7/8 ligand (R848) TLR9 (CpG oligodeoxynucleotides, or CpG) pVAX1-Sj26GST assessed their effects on immune system protection against S. japonicum. We show that...