A5101418557- Advanced Battery Technologies Research
- Bone Tissue Engineering Materials
- Advanced DC-DC Converters
- Electrospun Nanofibers in Biomedical Applications
- Geomechanics and Mining Engineering
- Magnetic properties of thin films
- Advancements in Battery Materials
- Electric Vehicles and Infrastructure
- Advanced MEMS and NEMS Technologies
- Geoscience and Mining Technology
- Coal Properties and Utilization
- Seismic Imaging and Inversion Techniques
- Mechanical and Optical Resonators
- Grouting, Rheology, and Soil Mechanics
- Graphene and Nanomaterials Applications
- Semiconductor Quantum Structures and Devices
- Organic and Molecular Conductors Research
- Electric and Hybrid Vehicle Technologies
- Semiconductor materials and devices
- Tissue Engineering and Regenerative Medicine
- Magnetism in coordination complexes
- Magnetic Field Sensors Techniques
- Nanoparticle-Based Drug Delivery
- Ecology and Vegetation Dynamics Studies
- Acoustic Wave Resonator Technologies
Xijing Hospital
2025
Henan Provincial Institute of Communications Planning Survey & Design (China)
2024
Fudan University
2023
Donghua University
2013-2023
Columbia University
2018-2022
Taiyuan University of Science and Technology
2022
Xi'an Technological University
2021
Shaoxing People's Hospital
2020
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials
2015-2018
Chongqing University
2008-2018
Surface fuctionalization plays a crucial role in developing efficient nanoparticulate drug-delivery systems by improving their therapeutic efficacy and minimizing adverse effects. Here we propose simple layer-by-layer self-assembly technique capable of constructing mesoporous silica nanoparticles (MSNs) into pH-responsive drug delivery system with enhanced biocompatibility. In this system, biocompatible polyelectrolyte multilayers alginate/chitosan were assembled on MSN's surface to achieve...
Bone morphogenetic protein-2 (BMP-2), a growth factor that induces osteoblast differentiation and promotes bone regeneration, has been extensively investigated in tissue engineering. The peptides of bioactive domains, corresponding to residues 73–92 BMP-2 become an alternative reduce adverse side effects caused by the use high doses protein. In this study, peptide functionalized mesoporous silica nanoparticles (MSNs-pep) were synthesized covalently grafting on surface via aminosilane linker,...
A drug-loaded implantable scaffold is a promising alternative for the treatment of tissue defect after tumor resection. In this study, mesoporous silica nanoparticles (MSNs) were used as carriers to load an anticancer drug - doxorubicin hydrochloride (DOX), and DOX-loaded MSNs (DOX@MSNs) subsequently incorporated into poly(l-lactic acid) (PLLA) nanofibers via electrospinning, resulting in new nanofibrous (PLLA/DOX@MSNs). The as-prepared composite was characterized by various techniques....
Developing biodegradable photothermal agent holds great significance for potential clinical translation of therapy. In the current study, one-pot hydrothermal synthesis MoS2 nanoflakes with desirable degradation capability was presented. The participation poly(acrylic acid) (PAA) in process could not only facilitate modification polyethylene glycol (PEG), but also bestow degradability to prepared nanoflakes. Moreover, PEGylated hybrid (MoS2-PPEG) exhibited excellent stability various medium...
The convenient modification of mesoporous silica nanoparticles (MSN) can provide great opportunities for constructing a new generation nanocarriers with multiple functions. In the current study, we fabricated multifunctional drug delivery system based on MSN capped by gadolinium-based bovine serum albumin complex (BSA-Gd) and hyaluronic acid (HA) via reductive-cleavable disulfide bond. this nanoparticle (MSN-ss-GHA), BSA-Gd component was prepared biomineralization acted as both smart...
The incorporation of microcarriers as drug delivery vehicles into polymeric scaffold for bone regeneration has aroused increasing interest. In this study, the aminated mesoporous silica nanoparticles (MSNs-NH2) were prepared and used dexamethasone (DEX) loading. Poly(l-lactic acid)/poly(ε-caprolactone) (PLLA/PCL) nanofibrous was fabricated via thermally induced phase separation (TIPS) served template, onto which drug-loaded MSNs-NH2 deposited by electrophoretic deposition (EPD)....
Vascularization and bone regeneration are two closely related processes during reconstruction. A three-dimensional (3D) scaffold with porous architecture provides a suitable microenvironment for vascular growth formation. Here, we present simple general strategy to construct nanofibrous poly(l-lactide)/poly(ε-caprolactone) (PLLA/PCL) interconnected perfusable microchannel networks (IPMs) based on 3D printing technology by combining the phase separation sacrificial template methods. The...
The construction of safe and stable theranostics is beneficial to realize simultaneous cancer diagnosis treatment. In this study, bovine serum albumin–gadolinium (BSA–Gd) complexes MoS2 nanoflakes (MoS2–Gd–BSA) were successfully married as for dual-modality magnetic resonance (MR)/photoacoustic (PA) imaging photothermal therapy (PTT). BSA–Gd prepared by the biomineralization method then conjugated with via an amide bond. as-prepared MoS2–Gd–BSA possessed a good photostability effect....
A highly porous composite scaffold with localized and sustained antibiotic release property for treatment of infected bone defects.
Vegetation and soil restoration are the key to ecological reconstruction in damaged areas of open-pit coal mining areas. Ecological stability is an important indicator degree restoration. In this study, process plant were investigated at different refuse dumps three mines, namely, Wulanhada (WLHD) mine, Liulingou (LLG) Jinzhengtai (JZT) Jungar Banner. Results show that organic matter, total N, available K increased with increase age two mines WLHD LLG. JZT firstly increased, then slightly...
The success of tissue engineered vascular grafts depends greatly on the synthetic tubular scaffold, which can mimic architecture, mechanical, and anticoagulation properties native blood vessels. In this study, small-diameter scaffolds were fabricated with different weight ratios poly(l-lactic acid) (PLLA) poly(l-lactide-co-ɛ-caprolactone) (PLCL) by means thermally induced phase separation technique. To improve property materials, heparin was covalently linked to...
Dual release of S1P/BMP-2 from porous nanofibrous scaffold promotes angiogenesis and ectopic bone formation.
A decomposable silica nanoparticle-incorporated electrospun mat as a carrier for anticancer drugs.
To achieve enhanced stimulatory effects on the osteogenic differentiation of stem cells, combination dual factors with synergistic bioactivity has been regarded as most effective and powerful strategy. In this study, polylysine-modified polyethylenimine (PEI-PLL) copolymers various molecular weight PEI blocks were first synthesized evaluated focusing their cytotoxicity gene transfection efficiency, results demonstrated that copolymer PEI-PLL-25k (synthesized using 25 kDa PEI) exhibited lower...
A nonisolated DC charger is proposed for electric vehicle (EV) battery system. The leakage current can be reduced by the novel charging system without bulky transformer. zero sequence voltage control method developed to stabilize common-mode voltage, thus, reduce current. fast includes two energy conversion stages: DC–DC converter side control; DC–AC grid interface and control. parameters of with <italic xmlns:mml="http://www.w3.org/1998/Math/MathML"...
This article outlines the design process of a high-efficiency (99.5% peak) transformerless dc electric vehicle fast charger in conjunction with relevant standards on conducted harmonics and leakage current. The topology is nonisolated which allows for elimination additional transformer volume losses that are present galvanically isolated topologies. Methods calculating optimal switching frequency inductance to minimize loss as function chosen device power level provided. Filter sizing...
Redistributive balancing brings many benefits to electric vehicles, such as increased range and more uniform cell degradation. Despite previous analyses suggesting a 17%–36% extension of battery lifetime, the cost systems has prevented technology from being adopted in practice. This study proposes simplified topology for battery-balancing auxiliary power modules (BB-APMs) with reduced magnetic material achieve cost-friendly solutions without sacrificing functionality or modes. The proposed...
Development of denoising algorithm for 3D acceleration signals is essential to facilitate accurate assessment human movement in body sensor networks (BSN). In this study, firstly were captured by self-developed nine-axis wireless BSN platform during 12 subjects performing regular walking. Then, noise was filtered using four common filters respectively: median filter, Butterworth low-pass discrete wavelet package shrinkage and Kalman filter. Finally, signal-to-noise ratio (SNR) correlation...
Macroporous nanofibrous vascular scaffold with improved biodegradability and smooth muscle cells infiltration prepared by dual phase separation technique Weizhong Wang,1 Wei Nie,1 Dinghua Liu,1 Haibo Du,1 Xiaojun Zhou,1 Liang Chen,1 Hongsheng Xiumei Mo,1 Lei Li,2 Chuanglong He1 1Key Laboratory of Science & Technology Eco-Textiles, Ministry Education, College Chemistry, Chemical Engineering Biotechnology, Donghua University, Shanghai 201620, China; 2Department Gastroenterology, Ninth...