A5100349121- Nanoplatforms for cancer theranostics
- Bone Tissue Engineering Materials
- Nanopore and Nanochannel Transport Studies
- Advanced Nanomaterials in Catalysis
- Electrospun Nanofibers in Biomedical Applications
- Pancreatic function and diabetes
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Dental materials and restorations
- Biosensors and Analytical Detection
- Orthopaedic implants and arthroplasty
- Graphene and Nanomaterials Applications
- MXene and MAX Phase Materials
- Advanced biosensing and bioanalysis techniques
- Fuel Cells and Related Materials
- Extracellular vesicles in disease
- Dental Implant Techniques and Outcomes
- Traditional Chinese Medicine Analysis
- Oral microbiology and periodontitis research
- Metabolomics and Mass Spectrometry Studies
- Nanoparticle-Based Drug Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Sensor and Energy Harvesting Materials
- Antibiotics Pharmacokinetics and Efficacy
Qingdao University
2018-2025
Yuhuangding Hospital
2023-2025
Institute of Computing Technology
2025
Sun Yat-sen University
2023-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2023-2025
Zhengzhou University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Institute of Hydrobiology
2025
Chinese Academy of Sciences
2025
Xi'an Jiaotong University
2022-2025
Abstract Photothermal cancer therapy has attracted considerable interest for treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can applied clinically. In study, we therefore develop flower-like molybdenum disulfide (MoS 2 ) nanoflakes and investigate their potential ablation of cells. MoS are synthesized via a facile hydrothermal method then modified with lipoic acid-terminated polyethylene glycol (LA-PEG), endowing obtained high...
Developing biodegradable photothermal agent holds great significance for potential clinical translation of therapy. In the current study, one-pot hydrothermal synthesis MoS2 nanoflakes with desirable degradation capability was presented. The participation poly(acrylic acid) (PAA) in process could not only facilitate modification polyethylene glycol (PEG), but also bestow degradability to prepared nanoflakes. Moreover, PEGylated hybrid (MoS2-PPEG) exhibited excellent stability various medium...
The convenient modification of mesoporous silica nanoparticles (MSN) can provide great opportunities for constructing a new generation nanocarriers with multiple functions. In the current study, we fabricated multifunctional drug delivery system based on MSN capped by gadolinium-based bovine serum albumin complex (BSA-Gd) and hyaluronic acid (HA) via reductive-cleavable disulfide bond. this nanoparticle (MSN-ss-GHA), BSA-Gd component was prepared biomineralization acted as both smart...
Vascularization and bone regeneration are two closely related processes during reconstruction. A three-dimensional (3D) scaffold with porous architecture provides a suitable microenvironment for vascular growth formation. Here, we present simple general strategy to construct nanofibrous poly(l-lactide)/poly(ε-caprolactone) (PLLA/PCL) interconnected perfusable microchannel networks (IPMs) based on 3D printing technology by combining the phase separation sacrificial template methods. The...
Three-dimensional (3D) printing can construct products with accurate complex architecture. Engineered bone tissues that promote vascularization and regulate directed differentiation of marrow-derived mesenchymal stem cells (BMSCs) are considered as an ideal substitute the healing for defects treatment. Herein, we fabricated a 3D printed BMSCs-laden scaffold using methacrylated gelatin silk fibroin (GelMA/SFMA) based bioinks along localized sustained release small molecule drug fingolimod...
Many ion channels in the cell membrane are believed to function as gates that control water and flow through transitions between an inherent hydrophobic state a stimuli-induced hydration state. The construction of nanofluidic gating systems with high efficiency reversibility is inspired by this behavior. A kind electrically actuated nanochannel developed integrating polypyrrole (PPy) micro/nanoporous film doped perfluorooctanesulfonate ions onto anodic aluminum oxide nanoporous membrane....
The construction of safe and stable theranostics is beneficial to realize simultaneous cancer diagnosis treatment. In this study, bovine serum albumin–gadolinium (BSA–Gd) complexes MoS2 nanoflakes (MoS2–Gd–BSA) were successfully married as for dual-modality magnetic resonance (MR)/photoacoustic (PA) imaging photothermal therapy (PTT). BSA–Gd prepared by the biomineralization method then conjugated with via an amide bond. as-prepared MoS2–Gd–BSA possessed a good photostability effect....
Abstract Small-scale electromagnetic soft actuators are characterized by a fast response and simple control, holding prospects in the field of miniaturized robotics. The use liquid metal (LM) to replace rigid conductor inside can reduce rigidity enhance actuation performance robustness. Despite research efforts, challenges persist flexible fabrication LM improvement performance. To address these challenges, we developed robust microplate actuator based on laser-induced selective adhesion...
Bioinspired artificial nanochannels exhibiting ion transport properties similar to biological channels have been attracting some attention for biosensors, separation technologies, and nanofluidic diodes. Herein, an easily available heterogeneous nanochannel shows both gating rectification characteristics when irradiated by ultraviolet light. The fabrication of includes the coating anatase TiO 2 porous layer on alumina supporter, followed a chemical modification with octadecyltrimethoxysilane...
To meet the urgent need of society for advanced photocatalytic materials, novel visible light driven heterostructured composite was constructed based on graphitic carbon nitride (g-C3N4) and fibrous TiO2. The g-C3N4/TiO2 (CNT) prepared through electrospinning technology followed calcination process. state g-C3N4 TiO2 tightly coupled. performance measured by degrading Rhodamine B. Compared to commercial (P25®) electrospun nanofibers, CNT higher than them. formation heterostructures enlarged...
Flower-like MoS<sub>2</sub> nanoparticles modified with bovine serum albumin loading doxorubicin hydrochloride for chemo-photothermal synergistic therapy.
It is a big challenge to develop polyethylene terephthalate (PET) artificial ligament with excellent osteogenetic activity enhance graft-bone integration for reconstruction. Herein, we evaluated the effect of biomineralization (BM) and electrodeposition (ED) method depositing calcium-phosphate (CaP) on PET in vitro vivo. Scanning electron microscopy energy-dispersive X-Ray spectrometer mapping analysis revealed that ED-CaP had more uniform particles element distribution (Ca, P O),...
3D printed scaffolds with micro and nano architectures that facilitate cell growth migration were prepared, the allowed deferoxamine release to accelerate bone formation.
In the repair of large segmental bone defects, tissue is often unable to heal due destruction vascular network near wound site. An ideal material should have both angiogenic and osteogenic capabilities. To achieve this goal, we used biodegradable mesoporous silica nanoparticles (MSNs) as a delivery vehicle for dexamethasone (DEX), small-molecule drug that induces differentiation. Subsequently, chitosan was covalently modified onto surface by glycidoxypropyltrimethoxysilane (GPTMS) construct...
This research proposes a novel 3D Convolutional Neural Network (CNN) to perform organ tissue segmentation from volumetric medical images. Accurate and efficient on the image of human is critical step towards disease diagnosis. For tasks, effectiveness conventional 2D CNNs are reduced due loss spatial information. To overcome obstacles, CNN that implements convolution pooling processes in space applied as substitution patch division scheme CNNs. By using CNN, becomes scalable direction,...