A5100696074- Thyroid Cancer Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 Clinical Research Studies
- Diabetes Treatment and Management
- Spinal Cord Injury Research
- Thyroid and Parathyroid Surgery
- Artificial Intelligence in Healthcare and Education
- RNA modifications and cancer
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Long-Term Effects of COVID-19
- Global Cancer Incidence and Screening
- Cervical Cancer and HPV Research
- Circadian rhythm and melatonin
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- COVID-19 and Mental Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Ferroptosis and cancer prognosis
- Cardiac Arrest and Resuscitation
- BRCA gene mutations in cancer
Ruijin Hospital
2024-2025
Shanghai Jiao Tong University
2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Nanchang University
2023-2025
Sun Yat-sen University
2017-2024
Guilin Medical University
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
Chinese PLA General Hospital
2019-2024
Johns Hopkins University
2024
New Technology (Israel)
2023
BackgroundStrategies for integrating artificial intelligence (AI) into thyroid nodule management require additional development and testing. We developed a deep-learning AI model (ThyNet) to differentiate between malignant tumours benign nodules aimed investigate how ThyNet could help radiologists improve diagnostic performance avoid unnecessary fine needle aspiration.MethodsThyNet was trained on 18 049 images of 8339 patients (training set) from two hospitals (the First Affiliated Hospital...
Introduction With intense deficiency of medical resources during COVID-19 pandemic, risk stratification is strategic importance. Blood glucose level an important factor for the prognosis infection and critically ill patients. We aimed to investigate prognostic value blood in patients with COVID-19. Research design methods collected clinical survival information 2041 consecutive hospitalized from two centers Wuhan. Patients without available were excluded. performed multivariable Cox...
SARS-CoV-2 inactivated vaccines have shown remarkable efficacy in clinical trials, especially reducing severe illness and casualty. However, the waning of humoral immunity over time has raised concern durability immune memory following vaccination. Thus, we conducted a nonrandomized trial among healthcare workers (HCWs) to investigate long-term sustainability SARS-CoV-2-specific B cells T stimulated by potential need for third booster dose. Although neutralizing antibodies elicited standard...
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are widely expressed on immune cell surfaces, play an important role in maintaining homeostasis and regulating inflammatory responses, increasingly emerging as potential targets for tumor immunotherapy. However, the expression profile crucial of SIGLEC11 gastric cancer (GC) remain unclear. This study aimed to elucidate prognostic relevance its microenvironment patients with GC. was analyzed using bioinformatics, immunohistochemistry,...
Visual interpretation of ultrasound (US) images alone may not be sensitive enough to detect important features potentially malignant thyroid nodules. The aim this study was develop a radiomics score using US imaging predict the probability for malignancy nodules as compared with Thyroid Imaging, Reporting, and Data System (TI-RADS) scoring criteria proposed by American College Radiology (ACR).One hundred thirty-seven pathologically proven from hospital 1 were enrolled training cohort, while...
<h3>Importance</h3> Owing to the good prognosis of differentiated thyroid cancer (DTC), guidelines recommend total thyroidectomy (TT) or lobectomy (TL) as surgical treatment for DTC with low intermediate risk recurrence. However, association these surgeries health-related quality life (HRQOL) patients recurrence is unclear. <h3>Objective</h3> To longitudinally compare HRQOL undergoing different surgeries. <h3>Design, Setting, and Participants</h3> This prospective observational longitudinal...
Abstract Emerging SARS-CoV-2 variants of concern (VOCs) harboring multiple mutations in the spike protein raise concerns on effectiveness current vaccines that rely ancestral protein. Here, we design a quadrivalent mosaic nanoparticle vaccine displaying proteins from prototype and 3 different VOCs. The elicits equivalent or superior neutralizing antibodies against variant strains mice non-human primates with only small reduction neutralization titers strain. Notably, it provides protection...
Importance To optimize the integration of artificial intelligence (AI) decision aids and reduce workload in thyroid nodule management, it is critical to incorporate personalized AI into decision-making processes radiologists with varying levels expertise. Objective develop an optimized for reducing radiologists’ while maintaining diagnostic performance compared traditional AI-assisted strategy. Design, Setting, Participants In this study, a retrospective set 1754 ultrasonographic images 1048...
Abstract SARS-CoV-2 variants have evolved a variety of critical mutations, leading to antigenicity changes and immune escape. The recent emerging Omicron variant attracted global attention due its significant resistance current antibody therapies vaccines. Here, we profiled the mutations other various circulating in parallel by computational interface analysis vitro experimental assays. We identified that lead diminished neutralization efficiency panel 14 antibodies diverse molecular...
Abstract Neurotransmitters are key modulators in neuro-immune circuits and have been linked to tumor progression. Medullary thyroid cancer (MTC), an aggressive neuroendocrine tumor, expresses neurotransmitter calcitonin gene-related peptide (CGRP), is insensitive chemo- radiotherapies, the effectiveness of immunotherapies remains unknown. Thus, a comprehensive analysis microenvironment would facilitate effective therapies provide evidence on CGRP’s function outside nervous system. Here, we...
Abstract Background Systemic corticosteroids are now recommended in many treatment guidelines, although supporting evidence is limited to 1 randomized controlled clinical trial (RECOVERY). Objective To identify whether were beneficial COVID-19 patients. Methods A total of 1514 severe and 249 critical hospitalized patients from 2 medical centers Wuhan, China. Multivariable Cox models, model with time-varying exposure propensity score analysis (inverse-probability-of-treatment-weighting [IPTW]...
Abstract The effectiveness of a 3 rd dose SARS-CoV-2 vaccines waned quickly in the Omicron-predominant period. In response to fast-waning immunity and threat Omicron variant concern (VOC) healthcare workers (HCWs), we conduct non-randomized trial (ChiCTR2200055564) which 38 HCWs volunteer receive homologous booster inactivated (BBIBP-CorV) 6 months after dose. primary secondary outcomes are neutralizing antibodies (NAbs) receptor-binding domain (RBD)-directed antibodies, respectively. 4 th...
To evaluate the effects of admission serum C-reactive protein-to-albumin ratio (CAR) in traumatic spinal cord injury (TSCI) severity evaluation and prognosis.
This study examines global trends in depression incidence among women of childbearing age (WCBA) from 1992 to 2021 and projects future through 2030. Using data the Global Burden Disease (GBD) applying age-period-cohort (APC) model, we analyzed temporal patterns across groups, periods, birth cohorts. The WCBA increased 77.57 million cases 127.02 2021, with age-standardized rate (ASIR) rising 5675.52 6490.04 per 100,000 people. estimated annual percentage change (EAPC) was -0.21 (95 % CI: 0.47...
Lymph node metastasis (LNM) assessment in patients with papillary thyroid carcinoma (PTC) is of great value. This study aimed to develop a deep learning model applied intraoperative frozen section for prediction LNM PTC patients.We established deep-learning (ThyNet-LNM) the multiple-instance framework predict using whole slide images (WSIs) from sections PTC. Data development and validation ThyNet-LNM were retrospectively derived four hospitals January 2018 December 2021. The was trained...
Human Schlafen 5 (SLFN5) has been reported to inhibit or promote cell invasion in tumours depending on their origin. However, its role breast cancer (BRCA) is undetermined.Differential expression analyses using The Cancer Genome Atlas (TCGA) data, clinical samples and lines were performed. Lentiviral knockdown overexpression experiments performed detect changes morphology, molecular markers invasion. Chromatin immunoprecipitation-sequencing (ChIP-Seq) luciferase reporter assays the...
Abstract A recent MMWR reported that the effectiveness of a 3 rd dose SARS-CoV-2 mRNA vaccine waned quickly in Omicron-predominant period. Similarly, substantial decline immune responses induced by inactivated vaccines was also observed our study. In response to fast waning and great threat Omicron variant concern (VOC) frontline healthcare workers (HCWs), 38 HCWs who were previous cohort investigating first three doses participated current study volunteered receive 4 th homologous booster....
In garlic cultivation, long-time monoculture has resulted in continuous-cropping obstacles. However, the cause not been studied to date.We analyzed soils from fields Pengzhou, China, determine obstacle related changes soil physicochemical properties and enzyme activities, diversity composition of bacterial fungal communities. Furthermore, we examined relationships between communities.The pH catalase, urease, invertase, polyphenol oxidase activities were lower cropping than healthy control...
Abstract Background LncRNAs regulate tumorigenesis and development in a variety of cancers. We substantiate for the first time that LINC00606 is considerably expressed glioblastoma (GBM) patient specimens linked with adverse prognosis. This suggests may have potential to glioma genesis progression, biological functions molecular mechanisms GBM remain largely unknown. Methods The expression ATP11B normal brain tissues was evaluated by qPCR, LINC00606/miR-486-3p/TCF12/ATP11B axis were verified...
Vaccination is important in influenza prevention but the immune response wanes with age. The circadian nature of system suggests that adjusting time vaccination may provide an opportunity to improve immunogenicity. Our previous cluster trial Birmingham suggested differences between morning and afternoon for some strains vaccine older adults. Whether this effect also seen a younger age group less likelihood compromised immunity unknown. We therefore conducted individual-based randomized...
Acute traumatic coagulopathy (ATC) is an extremely common but silent murderer; this condition presents early after trauma and impacts approximately 30% of severely injured patients who are admitted to emergency departments (EDs). Given that conventional coagulation indicators usually require more than 1 hour admission yield results-a limitation frequently prevents the ability for clinicians make appropriate interventions during optimal therapeutic window-it clearly vital importance develop...