A5076135351- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Thyroid Cancer Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- CRISPR and Genetic Engineering
- RNA regulation and disease
- RNA Research and Splicing
- Genetic Mapping and Diversity in Plants and Animals
- RNA and protein synthesis mechanisms
- Tactile and Sensory Interactions
- Genetic and phenotypic traits in livestock
- Bioinformatics and Genomic Networks
- Thyroid and Parathyroid Surgery
- Cancer Genomics and Diagnostics
- Advanced Sensor and Energy Harvesting Materials
- Atmospheric chemistry and aerosols
- Ferroptosis and cancer prognosis
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Metabolomics and Mass Spectrometry Studies
- Skin and Cellular Biology Research
- Catalysis for Biomass Conversion
Beijing Institute of Genomics
2021-2025
Chinese Academy of Sciences
2021-2025
Xiamen University
2024-2025
The First Affiliated Hospital, Sun Yat-sen University
2022-2025
Sun Yat-sen University
2021-2025
Chinese University of Hong Kong, Shenzhen
2025
Shanghai Center For Bioinformation Technology
2021-2024
Qingdao University of Science and Technology
2024
Northwestern Polytechnical University
2024
China University of Mining and Technology
2024
The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a family database resources to support global research in both academia and industry. With explosively accumulated multi-omics data at ever-faster rates, CNCB-NGDC is constantly scaling up updating its core through big archive, curation, integration analysis. In past year, efforts have been made synthesize growing knowledge, particularly single-cell omics precision medicine research, series newly...
Circular RNA (circRNA) is one type of noncoding that forms a covalently closed continuous loop. Similar to long (lncRNA), circRNA can act as microRNA (miRNA) 'sponges' regulate gene expression, and its abnormal expression related diseases such atherosclerosis, nervous system disorders cancer. So far, there have been no systematic studies on abundance profiles in human adult fetal tissues.We explored using RNA-seq data for six normal tissues (colon, heart, kidney, liver, lung, stomach) four...
Bottom-up emission inventories of atmospheric nitrogen oxides (NOx = NO + NO2) are usually limited to annual updates and have large uncertainties. The recent launch the Geostationary Environmental Monitoring Spectrometer (GEMS) first provides hourly measurements trace gas pollutants from space, enabling new insights into diurnal variations in anthropogenic NOx emissions. In this study, we present an improved top-down estimation using GEMS NO2 observations characterize emissions over cities...
Circular RNAs (circRNAs), covalently closed continuous RNA loops, are generated from cognate linear through back splicing events, and alternative events may generate different circRNA isoforms at the same locus. However, challenges of reconstruction quantification alternatively spliced full-length circRNAs remain unresolved. On basis internal structural characteristics circRNAs, we developed CircAST, a tool to assemble transcripts estimate their expression by using multiple splice graphs....
Abstract Chicken is a valuable model for understanding fundamental biology, vertebrate evolution and diseases, as well major source of nutrient-dense lean-protein-enriched food globally. Although it the first non-mammalian amniote genome to be sequenced, chicken still lacks systematic characterization functional impacts genetic variants. Here, through integrating 7,015 RNA-Seq 2,869 whole-genome sequence data, Genotype- Tissue Expression (ChickenGTEx) project presents pilot reference...
Abstract Neurotransmitters are key modulators in neuro-immune circuits and have been linked to tumor progression. Medullary thyroid cancer (MTC), an aggressive neuroendocrine tumor, expresses neurotransmitter calcitonin gene-related peptide (CGRP), is insensitive chemo- radiotherapies, the effectiveness of immunotherapies remains unknown. Thus, a comprehensive analysis microenvironment would facilitate effective therapies provide evidence on CGRP’s function outside nervous system. Here, we...
Virus integration into the human genome occurs frequently and represents a key driving event in disease. Many studies have reported viral sites (VISs) proximal to structural or functional regions of genome. Here, we systematically collected manually curated all VISs literature publicly available data resources construct Viral Integration Site DataBase (VISDB, https://bioinfo.uth.edu/VISDB). Genomic information including target genes, nearby nearest transcription start site, chromosome...
Abstract Papillary thyroid carcinoma (PTC) is heterogeneous and its molecular characteristics remain elusive. We integrated transcriptomic sequencing, genomic analysis clinicopathologic information from 582 tissue samples of 216 PTC 75 benign nodule (BTN) patients. discovered four subtypes including Immune-enriched Subtype, BRAF-enriched Stromal Subtype CNV-enriched Subtype. Molecular were validated in an external cohort 497 cases the TCGA. Tumors showed higher immune infiltration...
Background Androgenetic alopecia (AGA) is the most common type of androgen-associated hair loss. Previous studies have indicated an association between gut microbiota and AGA. To delve deeper, we executed a two-sample Mendelian randomization (MR) analysis to investigate potential causal relationship Methods A MR investigation was utilized into intricate interplay Information regarding 211 microbial taxa sourced from MiBioGen consortium. The summary statistics genome-wide (GWAS) for AGA were...
Abstract Drug response to many diseases varies dramatically due the complex genomics and functional features contexts. Cellular diversity of human tissues, especially tumors, is one major contributing factors different drug in samples. With accumulation single-cell RNA sequencing (scRNA-seq) data, it now possible study treatments at single cell resolution. Here, we present CeDR Atlas (available https://ngdc.cncb.ac.cn/cedr), a knowledgebase reporting computational inference cellular for...
The rapid advancement of sequencing technologies poses challenges in managing the large volume and exponential growth sequence data efficiently on time. To address this issue, we present GenBase (https://ngdc.cncb.ac.cn/genbase), an open-access repository that follows International Nucleotide Sequence Database Collaboration (INSDC) standards structures, for efficient nucleotide archiving, searching, sharing. As a core resource within National Genomics Data Center (NGDC) China Bioinformation...
Abstract Motivation Editome Disease Knowledgebase (EDK) is a curated resource of knowledge between RNA editome and human diseases. Since its first release in 2018, number studies have discovered previously uncharacterized editome-disease associations generated an abundance editing datasets. Thus, it desirable to make significant updates for EDK by incorporating more as well their related profiles. Results Here, we present v2.0, updated version based on both literature curation integrative...
Abstract Understanding genetic regulation of metabolism is critical for gaining insights into the causes metabolic diseases. Traditional metabolome-based genome-wide association studies (mGWAS) focus on static associations between single nucleotide polymorphisms (SNPs) and metabolite levels, overlooking changing relationships caused by genotypes within network. Notably, some metabolites exhibit changes in correlation patterns with other under certain physiological conditions while...
With the rapid advancements in computer graphics, rendering technologies, and artificial intelligence, 3D visualization of deep-space environments has become a transformative approach to improving teleoperation systems. Traditional Lunar-to-Earth faces challenges such as low bandwidth, high latency, limited situational awareness, which hinder intuitive efficient remote operations. To address these issues, we propose novel framework that integrates AI-driven reconstruction algorithms...
Circular RNAs (circRNAs) have recently been found to be expressed in human brain tissue, and many lines ofevidence indicate that circRNAs play regulatory roles neurodevelopment. Proliferation differentiation of neural stem cells (NSCs) are critical parts during development central nervous system (CNS).To date, there no reports ofcircRNA expression profiles the mouse NSCs. We hypothesizethat mayregulate gene proliferation anddifferentiation In this study, we obtained NSCs from wild-type...
Transcriptomic profiling is critical to uncovering functional elements from transcriptional and post-transcriptional aspects. Here, we present Gene Expression Nebulas (GEN, https://ngdc.cncb.ac.cn/gen/), an open-access data portal integrating transcriptomic profiles under various biological contexts. GEN features a curated collection of high-quality bulk single-cell RNA sequencing datasets by using standardized processing pipelines structured curation model. Currently, houses large number...
Abstract Background Malignant melanoma (MM) is a highly aggressive skin tumor with rising incidence and poor prognosis. Although current clinical treatments, including surgery, targeted therapy, immunotherapy, radiotherapy, have shown some efficacy, therapeutic options remain limited for elderly patients those metastatic disease, highlighting the urgent need novel strategies. In recent years, unique far-infrared radiation (FIR) properties of graphene demonstrated potential applications in...
The aim of this study was to explore the prevalence and predictors cesarean scar defect (CSD) at 6 weeks postpartum in Shanghai, China.Women scheduled receive a section (CS) were recruited from university hospital. Surgery-related factors, pregnancy complications, routine examinations, perioperative medications, physical signs collected transvaginal ultrasonography performed assess presence CSD postpartum. Multivariate logistic regression applied identify for CSD.A detected 223 514 women...