A5030762550- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Cytokine Signaling Pathways and Interactions
- Diabetes and associated disorders
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Nanoplatforms for cancer theranostics
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Cardiac Arrest and Resuscitation
- Single-cell and spatial transcriptomics
- interferon and immune responses
- Orthopedic Surgery and Rehabilitation
- Vascular Procedures and Complications
- Diagnosis and Treatment of Venous Diseases
- Chemokine receptors and signaling
- Advanced Nanomaterials in Catalysis
- Electromagnetic Fields and Biological Effects
Sun Yat-sen University
2020-2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2025
Huazhong University of Science and Technology
2019-2024
Weatherford College
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Tongji Hospital
2019-2020
Tertiary lymphoid structures (TLSs) are associated with enhanced immunity in tumors. However, their formation and functions colorectal cancer liver metastasis (CRLM) remain unclear. Here, we reveal that intra- peri-tumor mature TLSs (TLS+) improved clinical outcomes than TLS- Using single-cell-RNA-sequencing spatial-enhanced-resolution-omics-sequencing (Stereo-seq), TLS+ tumors enriched IgG
The tumor microenvironment is distinctive in primary and secondary liver cancer. B cells represent an important component of immune infiltrates. Here, we demonstrated that are regulator hepatocellular carcinoma (HCC) colorectal cancer metastasis (CRLM) microenvironments. displayed distinct developmental trajectories HCC CRLM. Single-cell analysis revealed IgG+ plasma preferentially accumulated HCC, whereas IgA+ were enriched Mechanistically, recruited by tumor-associated macrophages via the...
Targeted therapy and immunotherapy are transforming the treatment approach for intrahepatic cholangiocarcinoma (ICC). However, little is known about intertumor heterogeneity (ITH) of multifocal ICC its impacts on patient response to these treatments. We aimed characterize immunogenomic epigenomic guide decision making.We obtained 66 tumor samples from 16 patients with characterized immune using whole-exome sequencing, bulk single-cell RNA methylation microarray, multiplex immunostaining....
The reverse shoulder arthroplasty (RSA) may be a promising alternative for proximal humerus tumours because of good postoperative function. However, the conventional prosthesis can not meet individual needs and RSA has been associated with relatively high complication rate. Therefore, implant design surgical reconstruction technique warrant further study.Between September 2015 May 2018, 7 patients were treated via after en-bloc resection tumours. A 3D-printed guiding baseplate was used to...
To understand the current status of public knowledge automated external defibrillator (AED) and their willingness to use AED in Hubei Province, along with influencing factors. A self-designed questionnaire was used for convenience sampling Province. The consists three parts: basic information, questions, Data collected between May 2022 March 2023. total 1561 valid questionnaires were from 1602 distributed. In study conducted it found that 875 respondents (56.05%) had defibrillator, they...
Introduction: Mitochondria-targeted low-temperature photothermal therapy (LPTT) is a promising strategy that could maximize anticancer effects and overcome tumor thermal resistance. However, the successful synthesis of mitochondria-targeted nanodrug delivery system for LPTT still faces diverse challenges, such as laborious preparations processes, low drug-loading, significant systemic toxicity from carriers. Methods: In this study, we used tumor-targeting folic acid (FA)...
Mounting studies reveal the relationship between inflammatory markers and post-therapy prognosis. Yet, role of systemic indices in preoperative microvascular invasion (MVI) prediction for hepatocellular carcinoma (HCC) remains unclear.In this study, data 1,058 cases patients with HCC treated First Affiliated Hospital Sun Yat-sen University from February 2002 to May 2018 were collected. Inflammatory factors related MVI diagnosis selected by least absolute shrinkage selection operator (LASSO)...
<div>Abstract<p>The tumor microenvironment is distinctive in primary and secondary liver cancer. B cells represent an important component of immune infiltrates. Here, we demonstrated that are regulator hepatocellular carcinoma (HCC) colorectal cancer metastasis (CRLM) microenvironments. displayed distinct developmental trajectories HCC CRLM. Single-cell analysis revealed IgG<sup>+</sup> plasma preferentially accumulated HCC, whereas IgA<sup>+</sup> were...
<p>Figure S3</p>
<p>Figure S11</p>
<div>Abstract<p>The tumor microenvironment is distinctive in primary and secondary liver cancer. B cells represent an important component of immune infiltrates. Here, we demonstrated that are regulator hepatocellular carcinoma (HCC) colorectal cancer metastasis (CRLM) microenvironments. displayed distinct developmental trajectories HCC CRLM. Single-cell analysis revealed IgG+ plasma preferentially accumulated while IgA+ were enriched Mechanistically, recruited by tumor-associated...
<p>Figure S10</p>
<p>Figure S6</p>
<p>The RNA sequencing count data of 61 HCC and 62 CRLM tissues</p>
<p>Table S8</p>
<p>Table S7</p>
<p>Figure S3</p>
<p>Table S6</p>
<p>Figure S2</p>
<p>Figure S11</p>
<p>Figure S10</p>
<p>Figure S1</p>