A5101952796- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Congenital heart defects research
- Organ and Tissue Transplantation Research
- Zebrafish Biomedical Research Applications
- Transplantation: Methods and Outcomes
- Parvovirus B19 Infection Studies
- Renal and Vascular Pathologies
- MicroRNA in disease regulation
- Developmental Biology and Gene Regulation
- Cytomegalovirus and herpesvirus research
- Pharmacological Effects and Toxicity Studies
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Energy Harvesting in Wireless Networks
- Neurological Complications and Syndromes
- Renal Diseases and Glomerulopathies
- Hippo pathway signaling and YAP/TAZ
- Hepatitis C virus research
- Pregnancy and Medication Impact
- RNA modifications and cancer
- Antenna Design and Analysis
- Liver Disease Diagnosis and Treatment
Jilin Agricultural University
2025
Sun Yat-sen University
2016-2025
Fudan University
2011-2024
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Key Laboratory of Guangdong Province
2023-2024
Sixth Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
Zhongshan Hospital
2016-2024
Guangzhou University
2024
Sichuan University
2024
MicroRNA-10 (miR-10) was originally shown to regulate angiogenesis by directly modulating the levels of membrane-bound fms-related tyrosine kinase 1 (mflt1) and its soluble splice isoform sflt1 post-transcriptionally in zebrafish. Given that flt1 knockdown incompletely rescues angiogenic phenotypes miR-10 morphants, is unlikely be only important target endothelial cells (ECs). It will interesting investigate new mechanism responsible for defect induced knockdown. Firstly, we demonstrated...
Microvascular rarefaction increases vascular resistance and pressure in systemic arteries is a hallmark of fixed essential hypertension. Preventing by activation angiogenic processes could lower blood pressure. Endothelial tip cells sprouts direct branching microvascular networks; the process regulated microRNAs, particularly miR-30 family. We investigated contribution family members arteriolar morphogenesis via delta-like 4 (Dll4)-Notch signaling zebrafish model. The consists 5 (miR-30a-e)....
Background This study investigates the preventive benefits of sevoflurane against myocardial ischemia-reperfusion (I/R) injury, focusing on its effect modulation miR-21-5p. Methods In clinical study, patients with a history ischemia or other conditions requiring surgery were enrolled. Before surgery, anesthetized either propofol. The expression levels IMA, H-FABP, IL-1β, TNF-α, and IL-6 also examined. Additionally, miR-21-5p relationships IMA H-FABP. A cardiomyocyte hypoxia/reoxygenation...
Abstract Aim Long noncoding RNAs (lncRNAs) are novel intracellular ribonucleotides regulating the genome and proteome. The lncRNA activated by transforming growth factor β (TGF‐β) (lncRNA‐ATB) was discovered as a prognostic in hepatocellular carcinoma, gastric cancer, colorectal cancer. However, little is known about role of lncRNA‐ATB renal transplantation. This study aimed to assess expression transplant patients with acute kidney injury explore its postoperative pharmaceutical...
Postmenopausal osteoporosis (OPM) is a common type of in females. It systemic, chronic bone disease that presents as microstructure degradation osseous tissue, decreased mineral density and increased osteopsathyrosis caused by hypoovarianism reduced estrogen levels the body following menopause. In present study, role microRNA (miR)‑214‑5p regulation expression marrow stem cells (BMSCs) was investigated, its molecular mechanism osteogenic induction vitro assessed. When dexamethasone‑induced...
Background: Pneumonia accounts for the majority of infection-related deaths after kidney transplantation. We aimed to build a predictive model based on machine learning severe pneumonia in recipients deceased-donor transplants within perioperative period surgery. Methods: collected features transplant and used tree-based ensemble classification algorithm (Random Forest or AdaBoost) nonensemble classifier (support vector machine, Naïve Bayes, logistic regression) models. area under...
NLRP3, a decisive role in inflammation regulation, is obviously upregulated by oxidative stress kidney injury. The NLRP3 upregulation leads to unsolved and other pathological effects, contributing aggravation of injury even transition chronic disease (CKD). However, the mechanism for further remains largely elusive. In this study, we found 3'UTR was shortened response vivo vitro. Functionally, such shortening expression amplified inflammation, fibrogenesis, ROS production apoptosis,...
Huang G, Chen L‐Z, Qiu J, Wang C‐X, Fei J‐G, Deng S‐X, Li G‐D, Zhang L, Fu Q, Zeng W‐T, Zhao D‐Q. Prospective study of polyomavirus BK replication and nephropathy in renal transplant recipients China: a single‐center analysis incidence, reduction immunosuppression clinical course. Clin Transplant 2009 DOI: 10.1111/j.1399‐0012.2009.01141.x © John Wiley & Sons A/S. Abstract: Background: virus (BKV)‐associated (BKVAN) is an important cause dysfunction. Our aim was to determine the kinetics...
Cyclosporine, tacrolimus, and sirolimus are commonly used in renal transplant recipients to prevent rejection. However, information for comparative effects of these agents on the male productive system is extremely limited controversial. In a physiologically clinically relevant rat model unilateral nephrectomy, we demonstrated that long-term oral administration both cyclosporine at doses equivalent therapeutic levels postrenal patients significantly affects testicular development...
Both retinoic acid (RA) and Tbx1 are definitively indispensable for the development of pharyngeal arches. The defects produced by a loss highly resemble those induced hyper- hypo-RA. Based on these similarities, effects RA expression pattern were explored during arch in zebrafish. Whole-mount situ hybridization real-time quantitative PCR used. Zebrafish embryos treated with 5 x 10(-8)mol/L 10(-7)mol/L at 12.5 hours post fertilization 1.5 hours, respectively. showed that was expressed cardiac...
Background Elderly patients with end-stage renal disease have become the fastest growing population of kidney transplant candidates in recent years. However, risk factors associated long-term outcomes these remain unclear. Methods We retrospectively analyzed 166 recipients aged 60 years or older who underwent primary deceased transplantation between 2002 and 2013 our center. The main included 1-, 3- 5-year patient survival as well overall death-censored graft survival. independent affecting...
To compare the efficacy and safety of thymoglobulin compared with basiliximab in patients who had kidney transplants are at high risk for acute rejection delayed graft function.A retrospective review 1 or more factors function were given either induction therapy. Incidences rejection, antibody-treated function, chronic cancer, infection, leucopenia, thrombocytopenia between groups. Serum creatinine levels within year long-term patient survival also compared.A total 327 included....
Abstract Background There are three categories of deceased donors kidney transplantation in China, donation after brain death ( DBD ), circulatory DCD and followed by DBCD ) donors. The aim this study was to compare the outcomes from these Methods We retrospectively reviewed 469 recipients who received our hospital February 2007 June 2015. were divided into groups according source their donor kidneys: , or . primary endpoints delayed graft function DGF loss, patient death. Results warm...
Background Polyomavirus associated nephropathy (PVAN) is a significant cause of early allograft loss and the course difficult to predict. The aim this study identify factors influencing outcome for PVAN. Methods Between 2006 2014, we diagnosed PVAN in 48 (7.8%) 615 patients monitored BK virus every 1–4 weeks after modification maintenance immunosuppression. Logistic or Cox regression analysis were performed determine which risk independently affected clinical graft respectively. Results...
The molecular mechanisms underlying the development of ischemic cardiomyopathy (ICM) remain poorly understood. Gene expression profiling is helpful to discover changes taking place in ICM. aim this study was identify genes that are significantly changed during heart failure caused by differentially expressed (DEGs) were identified from 162 control samples and 227 ICM patients. PANTHER used perform gene ontology (GO), Reactome for pathway enrichment analysis. A protein–protein interaction...
Abstract Background This study was designed to investigate the association between donor-derived cell-free DNA (dd-cfDNA) and renal allograft injuries. Methods single-center enrolled 113 adult kidney transplant recipients with biopsies. Plasma urine dd-cfDNA detected by target region capture sequencing. Results fraction increased in multiple types of injuries, but most significantly antibody-mediated rejection. isolated rejection (1.94%, IQR: 1.15%, 2.33%) higher than T cell-mediated (0.55%,...