A5100722228- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Traditional Chinese Medicine Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Autophagy in Disease and Therapy
- Cardiac Ischemia and Reperfusion
- Pharmacological Effects of Natural Compounds
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- Cardiac Imaging and Diagnostics
- Sepsis Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Respiratory Support and Mechanisms
- Myofascial pain diagnosis and treatment
- Renin-Angiotensin System Studies
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Organ Transplantation Techniques and Outcomes
- Heart Rate Variability and Autonomic Control
Zigong First People's Hospital
2025
Fujian Medical University
2020-2025
Xian Yang Central Hospital
2025
Yichang Central People's Hospital
2022-2025
China Three Gorges University
2019-2025
Fujian Provincial Cancer Hospital
2020-2024
Sichuan University
2023-2024
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2022-2023
Tongji University
2022
Shanghai East Hospital
2020-2022
Mechanical overload can be classified into pressure and volume overload, causing concentric eccentric cardiac hypertrophy, respectively. Here, we aimed to differentiate the load-mediated signaling pathways involved in versus hypertrophy. Pressure or was imposed on C57BL/6J mice by transverse aortic constriction (TAC) regurgitation (AR), After surgery (2 wk), left ventricular structure function were evaluated echocardiographic, hemodynamic, histological analyses. Signaling related fibrosis,...
Objective. Anesthesia provides sedation and immobility, facilitating echocardiography in mice, but it influences cardiovascular function therefore outcomes of measurement. This study aimed to determine the effect optimal heart rate (HR) anesthetic timing on echocardiographic reproducibility under isoflurane anesthesia. Methods. Male C57BL/6J mice underwent high-resolution with relative fixed HRs timing. The same experiment was repeated once again after 1 week. Results. Echocardiography...
Qiliqiangxin (QL), a traditional Chinese medicine, has been used in the treatment of chronic heart failure. However, whether QL can benefit cardiac remodeling hypertensive state is unknown. We here examined effects on development hypertrophy through comparing those losartan C57BL/6 mice underlying transverse aorta constriction for 4 weeks. and were administrated at 0.6 mg 13.4 mg·kg·d, respectively. Cardiac hypertrophy, function, evaluated by echocardiography, catheterization, histology,...
The clinical manifestations of atypical hemolytic uremic syndrome （aHUS） are anemia, thrombocytopenia, and acute kidney injury. It is one the Thrombotic microangiopathy (TMA), with triggers for activation complement bypass pathway, such as infection pregnancy, present in 70-80% patients. Treatment this disease requires plasma exchange or eculizumab, we encountered a patient aHUS induced by gallstone-pancreatitis, after initial exchange, patient's condition was improved, but subsequent...
: Rubicon has been suggested to suppress autophagosome maturation by negatively regulating PI3KC3/Vps34 activity. However, the physiological function of remains elusive. We hypothesized that deficiency enhances autophagic flux in heart and affects cardiac function. knockout (KO) mice were generated piggyBac transposition. Loss was demonstrated at both mRNA protein levels. KO born Mendelian ratios. Autophagic flux, assessed bafilomycin A1-induced changes LC3 II abundance, enhanced compared...
Fibrotic cardiac muscle exhibits high stiffness and low compliance which are major risk factors of heart failure. Although heat shock transcription factor 1 (HSF1) was identified as an intrinsic cardioprotective factor, the role that HSF1 plays in fibrosis remains unclear. Our study aims to investigate pressure overload-induced underlying mechanism. phosphorylation significantly downregulated transverse aortic constriction (TAC)-treated mouse hearts mechanically stretched fibroblasts (cFBs)....
Abstract Purpose Standard intensive care unit (ICU) admission policies and treatment strategies for patients with cancer are still lacking. To depict the current status of admission, characteristics, outcomes in ICU. Methods A multicenter cross-sectional study was performed from May 10, 2021 to July 2021, ICU departments 37 cancer-specialized hospitals China. Clinical records all admitted aged ≥ 14 years duration > 24 h complete data were included. Demographic information, clinical...
Ryanodine receptor type 2 (RyR-2), the main Ca2+ release channel from sarcoplasmic reticulum in cardiomyocytes, plays a vital role regulation ofmyocardial contractile function and cardiac hypertrophy. However, of RyR-2 fibrosis during development hypertrophy remains unclear.In this study, we examined whether regulates TGFβ1, which is secreted cardiomyocytes exerts on using cultured fibroblasts neonatal rats. The expression was found only cardiomyocytesbut not fibroblasts. Mechanical stretch...
There are significant differences in terms of the pathophysiology and clinical manifestations between intra- extra-luminal bleeding, it is also difficult to determine reasonable management bleeding. This study analyze characteristics postoperative bleeding gastric cancer, explore intra-intestinal extra-intestinal bleeding.We collected data 2,978 patients with cancer from Department Surgery, Fujian Cancer Hospital, May 2014 September 2019. A total gastrectomy or a distal proximal subtotal...
We previously showed that Qiliqiangxin (QL) capsules could ameliorate cardiac hypertrophy and remodeling in a mouse model of pressure overload. Here, we compared the effects QL alone with those combined following 3 types antihypertensive drugs on dysfunction induced by overload for 4 weeks mice: an angiotensin II type 1 receptor (AT1-R) blocker (ARB), angiotensin-converting enzyme inhibitor (ACEI), β-adrenergic (β-AR) (BB). Adult male mice (C57B/L6) were subjected to either transverse aortic...
This study aimed to evaluate the incidence and prognosis of primary cardiac lymphoma (PCL) by using Surveillance, Epidemiology, End Results Program (SEER) database. Patients diagnosed with PCL disease in SEER database from 1975 2016 were included. Overall survival (OS) cause-specific (CSS) curves calculated Kaplan-Meier method compared log-rank test. Univariate multivariable Cox proportional hazard regression analyses used identify associations outcome measures. The was 0.011/100 000, a...
Abstract Background COVID-19 pandemic has forced physicians to quickly determine the patient’s condition and choose treatment strategies. This study aimed build validate a simple tool that can predict deterioration survival of patients. Methods A total 351 patients admitted Third People’s Hospital Yichang between 9 January 25 March 2020 were retrospectively analyzed. Patients randomly grouped into training ( n = 246) or validation 105) dataset. Risk factors associated with identified using...
There are controversies concerning the capacity of Rosuvastatin to attenuate heart failure in end-stage hypertension. The aim study was show whether might be effective or not for treatment. Twenty-one spontaneously hypertensive rats (SHRs) aged 52 weeks with were randomly divided into three groups: two receiving at 20 and 40 mg/kg/day, respectively, third, placebo comparison seven Wistar-Kyoto (WKYs) as controls. After an 8-week treatment, systolic blood pressure (SBP) echocardiographic...
Background It is challenges for surgeon to position the distal locking screw of a tibia intramedullary nail. The traditional free-hand (FH) technique related proficiency surgeons and has long learning curve. Furthermore, radiation dose accuracy placement should be taken into account. new technology, electromagnetic navigation system (ET), which radiation-free way locate drill bit. purpose our study evaluate results ET nail compare effects with FH technique. Methods Eighty-nine cases...
Abstract Cardiac side population cells ( CSP s) are promising cell resource for the regeneration in diseased heart as intrinsic cardiac stem cells. However, relative low ratio of s limited ability to repair and improve function effectively under pathophysiological condition. Which factors limiting proliferation unclear. Here, we show that urotensin II (UII) regulates by c‐Jun N ‐terminal kinase JNK ) density lipoprotein receptor‐related protein 6 LRP 6) signalling during pressure overload....
By employing a proteomic analysis on supernatant of mechanically stretched cardiomyocytes, we found that stretch induced significantly high level β-2 microglobulin (β2M), non-glycosylated protein, which is related to inflammatory diseases but rarely known in cardiovascular diseases. The present data showed serum β2M was increased patients with hypertension and further chronic heart failure (HF) as compared control group, the correlated cardiac dysfunction these patients. In pressure overload...
In mice, myocardial hypertrophic preconditioning (HP), which is produced by the removal of short-term transverse aortic constriction (TAC), was recently reported to render heart resistant responses induced subsequent reconstriction (Re-TAC). However, there no efficient noninvasive method for ensuring that repeated manipulations were successfully performed. We previously demonstrated ultrasound biomicroscopy (UBM) a and effective approach predicting TAC success. Here, we investigated value...
Background: This study aimed to compare serum cystatin C (CysC) levels between hypertensive and non-hypertensive patients, explore the correlation CysC left ventricular hypertrophy (LVH). We also investigated effects of pressure overload on cardiac expression secretion CysC, explored direct effect primary cardiomyocytes. Methods: Serum was compared in patients with hypertension (634 patients) those without (411 patients), LVH explored. A transverse aortic constriction (TAC) mouse model a...
To evaluate immunological protection of nitric oxide (NO) in hepatopulmonary syndrome and probable mechanisms ischemia-reperfusion (IR) injury rat liver transplantation.Sixty-six healthy male Wistar rats were randomly divided into three groups (11 donor/recipient pairs). In group II, organ preservation solution was lactated Ringer's with heparin 10, 000/μL at 4 °C. I III, the added, respectively, L-arginine or N(G)-L-arginine methyl ester (L-NAME) (1 mmol/L) based on recipients injected...