A5103081607- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Cardiac Fibrosis and Remodeling
- Cardiovascular Conditions and Treatments
- Coronary Interventions and Diagnostics
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Cardiac Imaging and Diagnostics
- Ferroptosis and cancer prognosis
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Congenital heart defects research
- Heart Rate Variability and Autonomic Control
- Circular RNAs in diseases
- Cardiac Arrest and Resuscitation
- Signaling Pathways in Disease
- GDF15 and Related Biomarkers
- Acute Kidney Injury Research
Shanghai East Hospital
2016-2025
Nanjing Medical University
2024
Tongji University
2014-2022
Los Angeles Medical Center
2021
Kaiser Permanente
2021
Zhongshan Hospital
2012-2014
Fudan University
2012-2014
The First Affiliated Hospital, Sun Yat-sen University
2012-2013
Sun Yat-sen University
2012-2013
Myocardial infarction (MI) is one of the leading causes global death. Dendritic cell-derived exosomes (DEXs) provide us with possibility improving cardiac function after MI but are limited by low retention times and short-lived therapeutic effects. In this study, we developed a novel drug delivery system incorporating alginate hydrogel that continuously releases DEXs investigated mechanisms underlying action in improvement MI.We incorporated (DEXs-Gel) controlled released ability rheology,...
Abstract The regenerative potential of alginate‐chitosan composite in bone and cartilage tissue has been well documented, but its utility cardiac engineering remained unknown. This study sought to determine whether early intramyocardial injection could prevent left ventricular (LV) remodeling after myocardial infarction (MI), leading a more favorable course restoration. In rat model acute MI, local hydrogel into the peri‐infarct zone preserved scar thickness, attenuated infarct expansion,...
Abstract Introduction Mesenchymal stem cells (MSCs) have potential for the treatment of myocardial infarction. However, several meta-analyses revealed that outcome cell transplantation is dissatisfactory. A series studies demonstrated combination and gene therapy was a promising strategy to enhance therapeutic efficiency. The aim this research investigate whether how overexpression hypoxia-inducible factor-1α (HIF-1α) co-transplantation mesenchymal can cardiac repair in Methods We...
Abstract Introduction Retrograde coronary venous infusion is a promising delivery method for cellular cardiomyoplasty. Poor cell retention the major obstacle to establishment of this as preferred route delivery. Here, we explored whether magnetic targeting could enhance retrograde in rat model myocardial infarction. Methods Rat mesenchymal stem cells were labeled with superparamagnetic oxide nanoparticles. The responsiveness MSCs was observed while flowed through tube that served blood...
Traditional histological methods for identifying ectopic thymus (ET) have significant limitations including high risk of false negatives. This study aims to evaluate the effectiveness flow cytometry in detecting ETs patients undergoing total thymectomy. We analyzed 864 samples from 103 using and hematoxylin eosin (H&E) staining. were identified by presence CD3mediumTCRvβmediumCD4+CD8+ T cells or Hassall's corpuscles H&E In discovery set, detected 69.2% samples, compared 23.6% methods. The...
Abstract Background Both the triglyceride glucose-waist height ratio (TyG-WHtR) index and elevated arterial blood pressure are risk factors for cardiovascular disease (CVD). However, it is uncertain whether TyG-WHtR can increase of CVD by influencing pressure, extent to which may mediate association between CVD. The purpose this study evaluate complex mean (MAP) with Methods All data in were obtained from China Health Retirement Longitudinal Study (CHARLS) free at baseline. was defined as...
Myocardial delivery of magnetic iron oxide nanoparticles (MNPs) might produce overload-induced myocardial injury, and the oxidative stress was regarded as main mechanism. Therefore, we speculated antioxidant modification be a reasonable strategy to mitigate toxicity MNPs.Antioxidant N-acetylcysteine (NAC) loaded into mesoporous silica coated Fe3O4 nanoparticles. Neonatal rat hypoxia/reoxygenation (H/R) cardiomyocytes were incubated with for 24 hrs. NAC can effectively iron-induced injury...
Magnetic targeting has the potential to enhance therapeutic effects of stem cells through increasing retention transplanted cells. To investigate magnetic intensities on cell transplantation, we performed different for mesenchymal (MSC)-targeting therapy in a rat model ischemia/reperfusion. Rat MSCs labeled with superparamagnetic oxide nanoparticles (SPIOs) were injected into left ventricular (LV) cavity rats during brief aorta and pulmonary artery occlusion. The 0.15 Tesla (T), 0.3 T, 0.6 T...
Abstract Kinase-catalyzed phosphorylation plays a crucial role in pathological cardiac hypertrophy. Here, we show that CDC-like kinase 4 (CLK4) is critical regulator of cardiomyocyte hypertrophy and heart failure. Knockdown Clk4 leads to hypertrophy, while overexpression confers resistance phenylephrine-induced Cardiac-specific -knockout mice manifest myocardial with progressive left ventricular systolic dysfunction dilation. Further investigation identifies nexilin (NEXN) as the direct...
The present study was carried out to investigate the hypothesis that organic nitrates can attenuate senescence of mesenchymal stem cells (MSCs), a superior cell source involved in regeneration and repair damaged tissue. MSCs were treated with high glucose (HG) order induce senescence, which markedly attenuated by pre-treatment isosorbide dinitrate (ISDN), commonly used nitrate, as indicated senescence-associated galactosidase (SA-β-gal) activity, p21 expression, well mRNA levels DNA...
The long-lasting hypointensities in cardiac magnetic resonance (CMR) were believed to originate from superparamagnetic iron oxide (SPIO)-engulfed macrophages during long-term stem cell tracking. However, the clearance capacity of ischemic heart was limited. Therefore, we speculated that extracellular SPIO particles may also be involved generation false-positive signals.Male swine mesenchymal cells (MSCs) incubated with for 24 hours, and labeling had no significant effects on either viability...
Primary percutaneous coronary intervention (PCI) has been the standard reperfusion strategy for patients with acute myocardial infarction (AMI) in contemporary era. Meanwhile, incidence and prognosis of left ventricular aneurysm (LVA) AMI remain ambiguous. The aim current study is to identify predictor long-term LVA anterior infarction.
Abstract Picroside II (P‐ ), one of the main active components scrophularia extract, which have anti‐oxidative, anti‐inflammatory effects, but its effect on hyperhomocysteinemia ( HH cy) induced endothelial injury remains to be determined. Here, we test whether P‐ protects cy‐induced dysfunction against oxidative stress, inflammation and cell apoptosis. In vitro study using HUVEC s, in mouse models, found that cy decreased SIRT 1 expression increased LOX ‐1 expression, subsequently causing...
Primary heart tumors are rare, with atrial myxomas being the most common type. Atrial can lead to embolisms, obstruction, and systemic symptoms. Herein, we report a case of 72-year-old woman who presented left myxoma at septal defect occluder, new acute cerebral infarction, MINOCA (myocardial infarction no obstructive coronary atherosclerosis). Left is primary cardiac tumor; however, arising after percutaneous occlusion rare. Additionally, patient multiple emboli. The underwent surgical...
In mice, myocardial hypertrophic preconditioning (HP), which is produced by the removal of short-term transverse aortic constriction (TAC), was recently reported to render heart resistant responses induced subsequent reconstriction (Re-TAC). However, there no efficient noninvasive method for ensuring that repeated manipulations were successfully performed. We previously demonstrated ultrasound biomicroscopy (UBM) a and effective approach predicting TAC success. Here, we investigated value...
Evidences abound that HSF1 and ALDH2 are of cardioprotective effect, yet there is still no report on whether can regulate to delay the occurrence heart failure. We first established pressure overload-induced failure model mice by transverse aortic constriction (TAC) discovered that, in forming period failure, changes expression recorded consistent trend. When was upregulated/downregulated delay/promote PKC also showed increased/decreased expression. And when upregulated/downregulated, role...