A5070820632- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Mitochondrial Function and Pathology
- Heart Failure Treatment and Management
- Autophagy in Disease and Therapy
- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Advanced Glycation End Products research
- Cardiovascular and exercise physiology
- Ion channel regulation and function
- Tissue Engineering and Regenerative Medicine
- Aldose Reductase and Taurine
- Cardiac Imaging and Diagnostics
- ECG Monitoring and Analysis
- Neurological disorders and treatments
- interferon and immune responses
- Diabetic Foot Ulcer Assessment and Management
- Intestinal Malrotation and Obstruction Disorders
- Sleep and Work-Related Fatigue
- Gastroesophageal reflux and treatments
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Shandong Provincial Hospital
2025
State Key Laboratory of Crystal Materials
2025
Shandong University
2025
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Sun Yat-sen University
2015-2024
Sun Yat-sen Memorial Hospital
2024
Shanghai Institute of Hematology
2019-2023
National Clinical Research Center for Digestive Diseases
2022-2023
The therapeutic effect of transplantation mesenchymal stem cells (MSCs) in myocardial infarction (MI) appears to be limited by poor cell viability the injured tissue, which is a consequence oxidative stress and pro-apoptotic factors. High density lipoprotein (HDL) reverses cholesterol transport has anti-oxidative anti-apoptotic properties. We, therefore, investigated whether HDL could protect MSCs from stress-induced apoptosis. derived bone marrow rats were pre-incubated with or without HDL,...
Mitochondrial cristae remain dynamic structures in order to adapt various physiopathologic processes (e.g., mitophagy and ferroptosis); thus, visualizing tracking different changes of are crucial for a deeper understanding these processes. Fluorescent probes that can realize long-term visualization mitochondrial under stimulated emission depletion (STED) microscopy powerful tools their in-depth research. However, there few reports on such probes, constructions challenging. Here, we reported...
Abstract Background Left bundle branch area pacing (LBBAP) emerges as an alternative to traditional right ventricular pacing, demonstrating safety and feasibility through superior access for implantation. Case summary An 89-year-old female, with a prior history of pacemaker pocket infection tricuspid endocarditis during follow-up, was referred our hospital management due sinus arrest. The patient underwent removal in the subclavian area, necessitating valvuloplasty infective endocarditis....
Mitochondria are dynamic organelles that have a variety of physiological states. Mitochondrial membrane potential (MMP) maintains mitochondrial activities and reflects cellular health viability. Thus, it is essential to dynamically monitor changes in MMP for understanding mitochondria-related biological processes. However, situ, synchronous quantitative tracking processes remains great challenge. In this work, we designed synthesized fluorescent probe CBTH undergoes spirocyclization response...
Abstract Background Whether right ventricular outflow tract (RVOT) pacing is superior to apex (RVA) in terms of synchrony, cardiac function, and remodeling patients with normal function still unknown. Hypothesis Right RVA function. Methods A total 96 consecutive high or third‐degree atrial block were enrolled randomized into 2 groups: RVOT group (n = 48) 48). Tissue Doppler imaging (TDI) 2D echocardiography performed study left (LV) systolic diastolic LV volumes, Results There no significant...
The present study was carried out to investigate the hypothesis that organic nitrates can attenuate senescence of mesenchymal stem cells (MSCs), a superior cell source involved in regeneration and repair damaged tissue. MSCs were treated with high glucose (HG) order induce senescence, which markedly attenuated by pre-treatment isosorbide dinitrate (ISDN), commonly used nitrate, as indicated senescence-associated galactosidase (SA-β-gal) activity, p21 expression, well mRNA levels DNA...
Methazolamide (MTZ) has been occasionally linked to the lethal Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which are associated with HLA-B*59:01. However, some MTZ-induced SJS/TEN (MTZ-SJS/TEN) cases negative for HLA-B*59:01, implying that other genetic factors besides HLA-B*59:01 contributing MTZ-SJS/TEN.To comprehensively identify HLA non-HLA susceptibility MTZ-SJS/TEN in Han Chinese.Eighteen patients MTZ-SJS/TEN, 806 subjects of population control 74 MTZ-tolerant...
Abstract Background The severe unfavorable effects of doxorubicin on the heart restrict its clinical usage. Numerous investigations document that cyclic GMP-AMP synthase (cGAS) activator interferon genes (STING) cascade influences inflammation along with immune response in a variety diseases. pathophysiological function cGAS-STING Doxorubicin-induced cardiomyopathy (DIC) is, nevertheless, unknown. Methods In vivo, cardiotoxicity was triggered by single dose intra-peritoneal inoculation (15...
Abstract Objectives The present study aimed to detect novel and time-dependent ECG parameters by analysing 24-h data, especially the area under waves. Design: Prospective, multicentre cohort Setting: Four hospitals in China Participants: High risk of sudden cardiac death, including 43 survivors death (SCD) or patients who suffered haemodynamic disorder due sustained ventricular tachycardia/ventricular fibrillation (SCDHR group), 138 with HF did not experience but were diagnosed dilated...
CRT and Myocardial Fibrosis Introduction Though cardiac resynchronization therapy (CRT) has now proved to be effective on reverse remodeling, data the underlying molecular changes are limited. The present study aims investigate expression of cytokines concerning myocardial fibrosis in dyssynchronous heart failure (HF) potential benefits CRT. Methods Results Left bundle branch ablation rapid pacing was performed induce a canine model asynchronous HF. Animals were randomly divided into sham...
Abnormal cardiac repolarization is closely associated with ventricular tachycardia/ventricular fibrillation (VT/VF). Myocardial ischemia and infarction aggravate dispersion, VT/VF could be lethal in the early stage of ST-segment elevation myocardial (STEMI). Unfortunately, cannot effectively predicted current clinical practice. The present study aimed to assess electrocardiographic parameters sinus rhythmic complex relation repolarization, e.g., QT interval T-peak T-end (TpTe), independently...
Pressure overload‑induced cardiac hypertrophy is associated with a complex spectrum of pathophysiological mechanisms, including the inflammation response. High mobility group box‑1 (HMGB1), pro‑inflammatory cytokine, not only increased in myocardium under pressure overload, but also exacerbates and dysfunction; however, underlying mechanisms have remained elusive. In present study, cultured cardiomyocytes were stimulated by mechanical stress and/or HMGB1 for various durations to examine role...
Several automatic algorithms have developed to optimize the timing cycle setting in cardiac resynchronization therapy (CRT). The present study aims investigate whether novel device-based SyncAV algorithm could elicit better synchrony and acute hemodynamic response.Thirty five patients undergoing CRT implantation were prospectively studied. device was programmed three biventricular (BiV) pacing modes sequentially after procedure: QuickOpt (mode I), with default 50 ms offset II), optimized...
Aim . Fibrosis had important effects on pressure overload-induced left ventricular (LV) dysfunction. High-mobility group box 1 (HMGB1), which was closely associated with fibrosis, involved in the cardiac injury. This study determines role of HMGB1 LV dysfunction under overload. Methods Transverse aortic constriction (TAC) operation performed male C57BL/6J mice to build model overload, while or PBS injected into wall. Cardiac function, collagen volume, and relevant genes were detected....
In patients with congestive heart failure, QRS duration (QRSd) is correlated left ventricular (LV) ejection fraction (LVEF), dyssynchrony and patients' prognosis. However, little known about the relationships between paced (pQRSd) to cardiac structures function in chronic right apical (RVA) pacing, which were investigated this study.Seventy implanted DDD(R) pacemaker for high- or third-degree atrioventricular block enrolled study pQRSd echocardiographic variables, including aortic root...
Abstract Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters predict CRT non-response. In present study, we try seek electro-echocardiographic predictors This is a retrospective study review total 227 dyssynchronous underwent implantation. Logistic analysis was performed between responders and non-responders. The primary outcome the occurrence improved left...
Abstract The mechanism of cardiac resynchronization therapy ( CRT ) remains unclear. In this study, mitochondria calcium uniporter MCU ), dynamin‐related protein‐1 DNM 1L/Drp1) and their relationship with autophagy in heart failure HF are investigated. Thirteen male beagle's dogs were divided into three groups (sham, , ). Animals received left bundle branch LBB ablation followed by either 8‐week rapid atrial pacing or 4‐week biventricular pacing. Cardiac function was evaluated...