A5100753747- Cardiac Ischemia and Reperfusion
- Vestibular and auditory disorders
- Sarcoma Diagnosis and Treatment
- Cardiomyopathy and Myosin Studies
- Intracranial Aneurysms: Treatment and Complications
- Autophagy in Disease and Therapy
- Bone Tumor Diagnosis and Treatments
- Glaucoma and retinal disorders
- Tuberculosis Research and Epidemiology
- Hepatitis B Virus Studies
- Cardiac Fibrosis and Remodeling
- Mycobacterium research and diagnosis
- Hepatitis C virus research
- Ophthalmology and Eye Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Influenza Virus Research Studies
- Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Phosphodiesterase function and regulation
- Diabetic Foot Ulcer Assessment and Management
- Hearing, Cochlea, Tinnitus, Genetics
- Renin-Angiotensin System Studies
- Cholinesterase and Neurodegenerative Diseases
- Orthopedic Surgery and Rehabilitation
- Plasma Diagnostics and Applications
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Institute of Zoology
2024-2025
Guangdong Academy of Sciences
2024-2025
Shanxi Medical University
2020-2024
Xian Yang Central Hospital
2011-2024
The First People's Hospital of Guiyang
2005-2024
Shaanxi Provincial People's Hospital
2020-2024
Shandong Academy of Agricultural Sciences
2024
Yue Bei People's Hospital
2023
Objective: Sympathetic nervous system activity in the myocardium is increased patients with heart failure. However, vivo mechanisms responsible for β-adrenoceptor-mediated cardiac hypertrophy or remodeling remain unclear. This study aimed to clarify role of reactive oxygen species (ROS) mitogen-activated protein (MAP) kinase activation and tissue isoproterenol (ISO)-infused rats.
The therapeutic effect of transplantation mesenchymal stem cells (MSCs) in myocardial infarction (MI) appears to be limited by poor cell viability the injured tissue, which is a consequence oxidative stress and pro-apoptotic factors. High density lipoprotein (HDL) reverses cholesterol transport has anti-oxidative anti-apoptotic properties. We, therefore, investigated whether HDL could protect MSCs from stress-induced apoptosis. derived bone marrow rats were pre-incubated with or without HDL,...
To search for more effective tuberculosis (TB) subunit vaccines, antigens expressed in different growth stages of Mycobacterium (M. tuberculosis), such as RpfE (Rv2450c) produced the stage resuscitation, Mtb10.4 (Rv0288), Mtb8.4 (Rv1174c), ESAT6 (Rv3875), Ag85B (Rv1886c) mainly secreted by replicating bacilli, and HspX (Rv2031c) highly dormant were selected to construct six fusion proteins: ESAT6-Ag85B-MPT64190-198-Mtb8.4 (EAMM), Mtb10.4-HspX (MH), ESAT6-Mtb8.4, Mtb10.4-Ag85B, ESAT6-Ag85B,...
An atmospheric cold plasma brush suitable for large area and low-temperature plasma-based sterilization is designed. Results demonstrate that the He/O2 more effectively kills Enterococcus faecalis than pure He plasma. In addition, efficiency values of depend on oxygen fraction in Helium gas. The using a proper ratio (2.5%) reaches optimum efficiency. After treatment, cell structure morphology changes can be observed by scanning electron microscopy. Optical emission measurements indicate...
Low density lipoprotein receptor-related protein 6 (LRP6), a wnt co-receptor, regulates multiple functions in various organs. However, the roles of LRP6 adult heart are not well understood. Methods: We observed expression with end-stage dilated cardiomyopathy (DCM) by western blot. Tamoxifen-inducible cardiac-specific knockout mouse was constructed. Hemodynamic and echocardiographic analyses were performed to these mice. Results: Cardiac dramatically decreased patients compared control...
Multiple myeloma (MM) is a plasma cell malignancy characterized by clonal proliferation in the bone marrow (BM). Previously, it was reported that G‑protein‑coupled receptor 4 (LGR4) contributed to early hematopoiesis and associated with poor prognosis patients MM. However, mechanism of homing migration, which critical for MM progression, remains unclear. In present study, counting, cycle BrdU assays were performed evaluate proliferation. Transwell assay Xenograft mouse models migration...
Pulmonary inflammation is the main cause of lung injury. Phosphodiesterase 4 (PDE4) a promising anti-inflammatory target for treatment respiratory diseases. Herein, we designed and synthesized 43 compounds in two novel series benzimidazole derivatives as PDE4 inhibitors. Among them, compound A5 showed highly selective inhibition PDE4, good safety, liver microsomal stability vitro. administration remarkably attenuated inflammatory infiltration pathologic injury models acute mice chronic...
Abstract The etiology and mechanism causing Meniere’s disease (MD) are not understood. present study investigated the possible molecular of autoimmunity autoinflammation associated with MD. Thirty-eight patients definite MD 39 normal volunteers were recruited, 48 human cytokines/chemokines quantified. In pure tone audiograms, tympanograms standard blood tests performed. mean hearing loss in worse ear was 44.1 dB nHL. Compared to referents, concentrations TNFα, IL1α, IL8, CTACK, MIP1α, MIP1β,...
Low density lipoprotein receptor-related protein 6 (LRP6), a Wnt co-receptor, induces multiple functions in various organs. We recently reported cardiac specific LRP6 deficiency caused dysfunction mice. Whether cardiomyocyte-expressed protects hearts against ischemic stress is largely unknown. Here, we investigated the effects of response to reperfusion (I/R) injury. Tamoxifen inducible overexpression mice were generated build I/R model by occlusion left anterior descending (LAD) coronary...
Wool is produced and controlled by hair follicles (HFs). However, little known about the mechanisms involved in HF development regulation. Sheep dermal fibroblasts (SDFs) play a key role initial stage of development. Analyzing molecular mechanism that regulates early superfine wool sheep great importance for better understanding morphogenesis process breeding fine sheep. Here, we show two microRNAs (miRNAs) affect HFs targeting genes are expressed SDFs. Meanwhile, overexpression inhibition...
Autophagy is a critical mechanism in both cancer therapy resistance and tumor suppression. Monoclonal antibodies have been documented to kill cells via apoptosis, antibody-dependent cellular cytotoxicity (ADCC) complement-dependent (CDC). In this study, we report for the first time that chLym-1, chimeric anti-human HLA-DR monoclonal antibody, induces autophagy Raji Non-Hodgkin's Lymphoma (NHL) cells. Interestingly, inhibition of by pharmacological inhibitors (3-methyladenine NH4Cl) or...
The etiology and underlying mechanism of Meniere's disease (MD) development are still unknown, although inflammation autoimmunity have been implicated as mechanisms. human endolymphatic sac (ES) has reported to innate adaptive immune capacity in local reactions. In vivo demonstration the ES patients with MD is missing literature. We report case a 47-year-old female patient diagnosed unilateral genetic variants cytokine markers indicating vascular congestion ES. Endolymphatic hydrops right...
Ryanodine receptor type 2 (RyR-2), the main Ca2+ release channel from sarcoplasmic reticulum in cardiomyocytes, plays a vital role regulation ofmyocardial contractile function and cardiac hypertrophy. However, of RyR-2 fibrosis during development hypertrophy remains unclear.In this study, we examined whether regulates TGFβ1, which is secreted cardiomyocytes exerts on using cultured fibroblasts neonatal rats. The expression was found only cardiomyocytesbut not fibroblasts. Mechanical stretch...
By employing a proteomic analysis on supernatant of mechanically stretched cardiomyocytes, we found that stretch induced significantly high level β-2 microglobulin (β2M), non-glycosylated protein, which is related to inflammatory diseases but rarely known in cardiovascular diseases. The present data showed serum β2M was increased patients with hypertension and further chronic heart failure (HF) as compared control group, the correlated cardiac dysfunction these patients. In pressure overload...
Cochlear implant (CI) speech performance is typically evaluated using well-enunciated produced at a normal rate by single talker. CI users often have greater difficulty with variations in production encountered everyday listening. Within talker, speaking rate, amplitude, duration, and voice pitch information may be quite variable, depending on the context. The coarse spectral resolution afforded limits perception of pitch, which an important cue for prosody tonal languages such as Mandarin...
Psoriasis is a complex and chronic inflammatory disease. Current drugs help control the symptoms of psoriasis but make no cure, urging discovery novel drugs. We report in this paper new phosphodiesterase 4 (PDE4) inhibitors for treatment psoriasis. designed synthesized 45 compounds, among which
Our previous work indicated that the activation of Toll-like receptor (TLR) 4 signaling pathway contributed to noise-induced cochlear inflammation. Previous studies have reported low-molecular-weight hyaluronic acid (LMW-HA) accumulates during aseptic trauma and promotes inflammation by activating TLR4 pathway. We hypothesized LMW-HA or enzymes synthesizing degrading HA might be involved in inflammation.The present study included two arms. The first arm was noise exposure study, which TLR4,...