A5101979499- Hydrology and Watershed Management Studies
- Soil and Water Nutrient Dynamics
- Pancreatic and Hepatic Oncology Research
- Herpesvirus Infections and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Nutrition and Health in Aging
- Cytomegalovirus and herpesvirus research
- Cardiac, Anesthesia and Surgical Outcomes
- Asthma and respiratory diseases
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Water Quality and Pollution Assessment
- Cardiovascular Function and Risk Factors
- Soil erosion and sediment transport
- Musculoskeletal pain and rehabilitation
- RNA modifications and cancer
- FOXO transcription factor regulation
- Manufacturing Process and Optimization
- Hydrocarbon exploration and reservoir analysis
- Genetics, Aging, and Longevity in Model Organisms
- Statistical Methods in Clinical Trials
- Spine and Intervertebral Disc Pathology
- Fibroblast Growth Factor Research
Changjiang Water Resources Commission
2016-2025
Zhejiang Shuren University
2023
Guangdong Provincial Hospital of Traditional Chinese Medicine
2023
Yuhuangding Hospital
2022
Xian Yang Central Hospital
2021
Wenzhou Medical University
2015-2020
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020
Bioscience (China)
2020
Queen's University
2012-2019
University of Toronto
2019
The "obesity paradox" reflects an observed relationship between obesity and decreased morbidity mortality, suggesting improved health outcomes for obese individuals. Studies examining the high body mass index (BMI) adverse after cardiac surgery have reported conflicting results.The study population (N=78 762) was comprised of adult patients who had undergone first-time coronary artery bypass (CABG) or combined CABG/aortic valve replacement (AVR) from April 1, 1998 to October 31, 2011 in...
Abstract Long noncoding RNA s (lnc s), a novel class of transcripts that have critical roles in carcinogenesis and progression, emerged as important gene expression modulators. Recent evidence indicates lnc taurine‐upregulated 1 ( TUG 1) functions an oncogene numerous types human cancers. However, its function the development cervical cancer remains unknown. The aim this research was to investigate clinical significance biological cancer. found be significantly upregulated tissues four cell...
<h3>Objective</h3> Tumour biomarkers are used as indicators for cancer screening and predictors therapeutic responses prognoses in patients. We aimed to identify genetic loci that influence concentrations of antigen 19-9 (CA19-9), carcinoembryonic (CEA) α fetoprotein (AFP), investigated the associations between significant single nucleotide polymorphisms (SNPs) with risks oesophageal squamous cell (OSCC), pancreatic hepatocellular cancers. <h3>Design</h3> carried out a genome wide...
Abstract We propose a nonparametric method to assess the effects of one or more covariates on cure rate for survival data with fraction. The extends existing work single sample and multiple cases also allows continuous covariate. proposed estimator is shown be consistent asymptotically normal. A simulation study shows that estimates covariate effect smaller biases than semi‐parametric models, particularly when models mis‐specify effect. applied leukaemia patients age chance being cured after...
Abstract This study focuses on the sources of organic carbon (OC) in surface sediments reservoirs mountainous regions, as well their dynamics and contribution mechanisms cycle. Spatial variations carbon, n‐alkanes, δ 13 C, 15 N were analyzed, a Bayesian isotope mixing model was applied to quantify relative contributions different OC sources. The results indicate that concentration range is 0.88%–3.72%. average long‐chain n‐alkanes 3.69 μg/g, accounting for 71.4%, indicating main source...
Abstract Hydrologic regimes are affecting terrestrial carbon transformation, chemical weathering and lateral transport. However, its impacts on dissolved export patterns remains elusive. In this study, we collected a 2‐year high‐frequency inorganic (DIC) organic (DOC) dataset, namely wet year (Rainfall = 1,158 mm) dry 603 mm). The results showed that drought led to significant decrease in concentration discharge during the monitoring period. During non‐storm periods, DIC DOC shifted from...
The present study was carried out to investigate the hypothesis that organic nitrates can attenuate senescence of mesenchymal stem cells (MSCs), a superior cell source involved in regeneration and repair damaged tissue. MSCs were treated with high glucose (HG) order induce senescence, which markedly attenuated by pre-treatment isosorbide dinitrate (ISDN), commonly used nitrate, as indicated senescence-associated galactosidase (SA-β-gal) activity, p21 expression, well mRNA levels DNA...
Abstract Death domain-associated protein (DAXX) is a complex biological multifunctional and involved in the tumorigenesis progression of multiple cancers. The accumulation DAXX nucleus common phenomenon tumor cells. However, altering subcellular localizations results different functions, we also found that its nuclear/cytoplasmic ratio (NCR) was associated with poor prognosis gastric cancer (GC). In this study, investigated effect cytoplasmic nuclear (cDAXX nDAXX) GC underlying mechanisms....
We aimed to construct and validate a radiomics-based nomogram model derived from gadoxetic acid-enhanced magnetic resonance (MR) images predict cytokeratin (CK) 19-positive (+) hepatocellular carcinoma (HCC) patients' prognosis.A two-center time-independent cohort of 311 patients were retrospectively enrolled (training cohort, n = 168; internal validation 72; external 71). A total 2286 radiomic features extracted multisequence MR with the uAI Research Portal (uRP), feature was established....
Abstract In addition to regulating apoptosis via its interaction with the death domain of Fas receptor, associated protein 6 (Daxx) is also known be involved in transcriptional regulation, suggesting that function Daxx depends on subcellular localization. this study, we aimed explore localization gastric cancer ( GC ) cells and correlate findings clinical data patients. Seventy pairs tissue samples adjacent normal tissue) were analyzed immunohistochemically for expression (nuclear...
Malnutrition in patients with gastric cancer (GC) normal body mass index (BMI) is often ignored. This study aimed to explore the role of sarcopenia predicting postoperative complication and long-term survival GC BMI. We included BMI (18.5 kg/m
Colorectal cancer (CRC) is one of the deadliest tumours, but its pathogenesis remains unclear. The involvement differentially expressed long non-coding RNAs (lncRNAs) in CRC tumorigenesis makes them suitable tumour biomarkers.Here, we screened 150 cases and 85 paracancerous tissues GEO database for lncRNAs. levels lncRNA candidates 84 tissue samples were validated by qRT-PCR their clinical significance was analyzed. We identified 15 lncRNAs with differential expression tumours; among them,...
// Wenjing Chen 1, * , Kezhi Lin 2, Liang Zhang 1 Gangqiang Guo 3 Xiangwei Sun Jing 4 Lulu Ye Sisi Chenchen Mao Jianfeng Xu Lifang Lubin Jiang 3, 5 Xian Shen Xiangyang Xue Department of General Surgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China 2 Experimental Center, Microbiology and Immunology, Institute Molecular Virology Tropical Medicine, Rheumatology, Key Laboratory Unit Pathogen-Host Interaction Epigenetics, Institut Pasteur Shanghai, These authors...
Instrumented lumbar surgeries, such as fusion and disc replacement, are increasingly being used in the United States for low back pain, with utilization rates approaching those of total joint arthroplasty. It is unknown whether there a similar pattern Canada. We sought to determine medical costs instrumented surgeries single-payer system compare these hip knee replacements.We included Ontarians aged 20 years older who underwent surgery or replacement between April 1993 March 2012....
Non-point source nitrogen loss poses a risk to sustainable aquatic ecosystems. However, non-point sources, as well impaired river segments with high concentrations, are difficult monitor and regulate because of their diffusive nature, budget constraints, resource deficiencies. For the purpose catchment management, Bayesian maximum entropy approach spatial regression models have been used explore spatiotemporal patterns loss. In this study, total 18 sampling sites were selected along network...
Human cytomegalovirus is a significant agent of hepatic involvement in neonates. In this study, we investigated the polymorphisms and features viral genes UL144 UL146 as well their significance to congenital involvement. 79 neonates with infection involvement, full length were successfully amplified 73.42% 60.76% cases, respectively. Sequencing indicated that both hypervariable. Notably, genotype B was highly associated aspartate aminotransferase (P = 0.028) lactate dehydrogenase 0.046)....
Studying the effect of hydrological connectivity and landscape patterns on nitrogen (N) phosphorus (P) load in convective basins can help uncover mechanisms non-point source pollution a watershed. This study simulated output total (TN) (TP) Longxi River Basin (LRB) using Soil Water Assessment Tool (SWAT), analyzed effects terrain, configuration, composition, ouput volume TN TP Random Forest (RF) from 2019 to 2022. The results indicate that N P LRB is higher summer autumn than winter spring,...