A5035288859- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Animal Disease Management and Epidemiology
- Aquaculture disease management and microbiota
- Herpesvirus Infections and Treatments
- Gut microbiota and health
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Animal Virus Infections Studies
- RNA modifications and cancer
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Salmonella and Campylobacter epidemiology
- Brucella: diagnosis, epidemiology, treatment
- Escherichia coli research studies
- Cytomegalovirus and herpesvirus research
- Diagnosis and treatment of tuberculosis
- Antimicrobial Peptides and Activities
- Toxoplasma gondii Research Studies
- Immune Response and Inflammation
- Virology and Viral Diseases
- Vector-Borne Animal Diseases
- MicroRNA in disease regulation
Huazhong Agricultural University
2016-2025
Yangpu Hospital of Tongji University
2016-2025
Development Research Center
2022-2025
Shanghai Zhangjiang Laboratory
2022-2024
Ministry of Agriculture and Rural Affairs
2020-2024
State Key Laboratory of Agricultural Microbiology
2016-2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2019-2024
Wuhan College
2017-2024
Murdoch University
2020-2023
Ministry of Science and Technology of the People's Republic of China
2019-2023
BASys (Bacterial Annotation System) is a web server that supports automated, in-depth annotation of bacterial genomic (chromosomal and plasmid) sequences. It accepts raw DNA sequence data an optional list gene identification information provides extensive textual hyperlinked image output. uses >30 programs to determine ∼60 subfields for each gene, including gene/protein name, GO function, COG possible paralogues orthologues, molecular weight, isoelectric point, operon structure, subcellular...
A cattle pangenome representation was created based on the genome sequences of 898 representing 57 breeds. The identified 83 Mb sequence not found in reference genome, 3.1% novel compared with 2.71-Gb reference. catalog structural variants developed from this population 3.3 million deletions, 0.12 inversions, and 0.18 duplications. Estimates breed ancestry hybridization between breeds using insertion/deletions as markers were similar to those produced by single nucleotide polymorphism–based...
Abstract Background Previous studies have examined the associations of health literacy and social support with medication adherence among patients hypertension. However, limited evidence exists regarding mechanisms underlying relationship between these factors adherence. Purpose To explore prevalence its determinants in hypertension Shanghai. Methods A community-based cross-sectional study was conducted 1697 participants We collected sociodemographic clinical characteristics as well data...
Mycoplasma bovis pneumonia in cattle has been epidemic China since 2008. To investigate M. pathogenesis, we completed genome sequencing of strain HB0801 isolated from a lesioned bovine lung Hubei, China. The genomic plasticity was determined by comparing with ATCC® 25523™/PG45 cow mastitis milk, Chinese Hubei-1 tissue, and 16 other Mycoplasmas species. Compared to PG45, the size reduced 11.7 kb. Furthermore, large chromosome inversion (580 kb) confirmed all isolates including HB0801, HB1007,...
To determine the nationwide status of persistent BVDV infection in different bovine species China and compare test methods, a total 1379 serum samples from clinical healthy dairy cattle, beef yaks (Bos grunniens), water buffalo (Bubalus bubalis) were collected eight provinces 2010 to 2013. The analyzed using commercial antibody (Ab) antigen (Ag) detection kits, RT-PCR based on 5'-UTR Npro gene sequencing. Results showed that overall positive rates for Ab, Ag 58.09% (801/1379), 1.39%...
Mastitis is one of the most widespread infectious diseases that adversely affects profitability dairy industry worldwide. Accurate diagnosis and identification pathogens early to cull infected animals minimize spread infection in herds critical for improving treatment effects farm welfare. The major causing mastitis pathogenesis are assessed first. recent advanced strategies detecting mastitis, including genomics proteomics approaches, then evaluated . Finally, advantages disadvantages each...
Abstract Mycoplasma bovis causes considerable economic losses in the cattle industry worldwide. In mycoplasmal infections, adhesion to host cell is of utmost importance. this study, amino acid sequence NOX was predicted have enzymatic domains. The nox gene then cloned and expressed Escherichia coli . activity recombinant (rNOX) confirmed based on its capacity oxidize NADH NAD + reduce O 2 H adherence rNOX embryonic bovine lung (EBL) cells with confocal laser scanning microscopy,...
This study aimed to determine the activity of one Mycoplasma bovis nuclease encoded by MBOV_RS02825 and its association with cytotoxicity. The bioinformatics analysis predicted that it encodes a Ca(2+)-dependent based on existence enzymatic sites in TNASE_3 domain derived from Staphylococcus aureus thermonuclease (SNc). We cloned purified recombinant MbovNase (rMbovNase), demonstrated digesting bovine macrophage linear DNA RNA, closed circular plasmid presence 10 mM Ca(2+) at 22-65 °C. In...
Bovine herpesvirus1 (BoHV-1) is a major bovine pathogen. Despite several vaccines being available to prevent viral infection, outbreaks are frequent and cause important economic consequences worldwide. The development of new antiviral drugs therefore highly desirable. In this context, genome replication represents potential target for therapeutic intervention. BoHV-1 dsDNA molecule whose takes place in the nuclei infected cells mediated by encoded DNA polymerase holoenzyme. Here, we studied...
Cyclical oversupply and non-profitability situations have led to pig industry consolidations in the People's Republic of China, with many smaller farmers leaving industry. In 2007, pork supply worsened due outbreaks 'high fever blue-ear disease', a complex disease issue that includes highly virulent porcine reproductive respiratory syndrome, circovirus classical swine fever. Best estimates suggest 50 million pigs were affected. More recent natural disasters (earthquakes/freezing winters)...
Type A influenza viruses (IAVs) cause significant infections in humans and multiple species of animals including pigs, horses, birds, dogs some marine animals. They are complicated phylogenetic diversity distribution, analysis their distribution from a panorama view has not been updated for years.139,872 protein sequences IAVs GenBank were selected, they aligned phylogenetically analyzed using the software tool MEGA 7.0. Lineages subordinate lineages classified according to topology trees...
This study identified urinary biomarkers for tuberculosis (TB) diagnosis. The urine proteomic profiles of 45 pulmonary patients prior to anti-TB treatment and healthy controls were analyzed compared using two-dimensional electrophoresis with matrix-assisted laser desorption/ionization time flight mass spectrometry. Nineteen differentially expressed proteins preliminarily, western blotting qRT-PCR performed confirm these changes at the translational transcriptional levels, respectively,...
Brucellosis has re-emerged in China recent years, resulting an increasing health burden and economic losses for humans the livestock industries. This study integrated data from human brucellosis surveillance systems to explore changing epidemiology of 2004 2018 China. A total 524,980 cases were reported, with average annual incidence being significantly higher period 2012–2018 than 2004–2011 (3.3 vs. 1.9 per 100,000 residents). An autoregressive moving (ARIMA) model predicted upward trend...
Bovine viral diarrhea virus (BVDV) is an important livestock pathogen responsible for causing significant economic losses. The emerging and novel BVDV isolates are clinically biologically important, as there highly antigenic diverse pathogenic differences among genotypes. However, no study has yet compared the virulence of predominant genotype (BVDV-1a, 1b, 1m) in China isolate BVDV-1v. serological relationship these genotypes not been described. In this study, we isolated three from calves...
The snub-nosed monkey (Rhinopithecus roxellanae) is an endangered animal species mainly distributed in China and needs to be protected. Gut microbiome important determinant of health population survival as it affects the adaptation animals different foods environments under kinetic changes intrinsic extrinsic factors. Therefore, this study aimed elucidate gut fecal profiles monkeys affected by several factors, including raising patterns (captive vs. wild), age, sex, diarrheal status provide...
Probiotics are a prominent alternative to antibiotics in antimicrobial-free broiler farming. To assess the effect of Sphingomonas sp. Z392 (isolated and identified) on growth, 600 one-day-old Kebao chickens were randomly divided into control group an experimental group. Each had three replicates, with 100 being raised each replicate. Regarding chickens, 4.0 × 105 CFU/mL was added their drinking water. Then, changes body weight, EPI, intestinal histological structure, gut microbiota examined....