A5031534045- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Neurological diseases and metabolism
- GDF15 and Related Biomarkers
- Environmental DNA in Biodiversity Studies
- Muscle Physiology and Disorders
- Lipid metabolism and disorders
- Cancer Genomics and Diagnostics
- Genomics and Phylogenetic Studies
Chinese Academy of Tropical Agricultural Sciences
2024-2025
Zhanjiang Experimental Station
2024-2025
Huazhong Agricultural University
2022-2023
A cattle pangenome representation was created based on the genome sequences of 898 representing 57 breeds. The identified 83 Mb sequence not found in reference genome, 3.1% novel compared with 2.71-Gb reference. catalog structural variants developed from this population 3.3 million deletions, 0.12 inversions, and 0.18 duplications. Estimates breed ancestry hybridization between breeds using insertion/deletions as markers were similar to those produced by single nucleotide polymorphism–based...
The Leizhou Black Goat (LZBG), a prominent breed in tropical China's meat goat industry, frequently exhibits inherent muscle atrophy and malnutrition-related traits. Particularly, muscles critical for support, such as the legs, often display severe symptoms. This study aimed to investigate differential genes signaling pathways influencing development across various locations LZBG from muscular atrophy-affected family. Differential expression analysis revealed 536 mRNAs with significant...
Abstract As an important source of genomic variation, copy number variation (CNV) contributes to environmental adaptation in worldwide buffaloes. Despite this importance, CNV divergence between swamp buffaloes and river has not been studied previously. Here, we report 21 152 regions (CNVRs) 141 20 breeds detected through multiple calling strategies. Only 248 CNVRs were shared buffalo buffalo, reflecting great the two subspecies. Population structure analysis based on CNVs successfully...
The ANGPT1 gene plays a crucial role in the regulation of angiogenesis and muscle growth, with previous studies identifying copy number variations (CNVs) within this among Leizhou black goats. In study, we investigated three CNVs 417 individuals LZBG using quantitative PCR (qPCR), examining impact different CNV types on expression their associations growth meat quality traits. Notably, CNV-1 (ARS1_chr14:24950001-24953600) overlaps protein-coding regions conserved domains; its gain-of-copies...
Extrachromosomal circular DNA (eccDNA) is an important fraction of the genome. Recent studies proved that eccDNA plays roles in genetic variation, aging and environmental adaptation, which have drawn wide attention. However, characteristics cattle remain unclear. Here, we studied eccDNAs from 676 58 breeds using whole genome sequencing datasets. In total, 47 355 high-confidence were identified covered 4.6% autosomes length. Similarly to other species, preferentially located genic repeat...