A5034776291- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Cancer-related molecular mechanisms research
- Cardiac Imaging and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Acute Myocardial Infarction Research
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Signaling Pathways in Disease
- Angiogenesis and VEGF in Cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Platelet Disorders and Treatments
- Mitochondrial Function and Pathology
- Cardiovascular Disease and Adiposity
- Cardiac Ischemia and Reperfusion
- Advanced MRI Techniques and Applications
- Traditional Chinese Medicine Analysis
- Diabetes Treatment and Management
Shandong First Medical University
2025
Affiliated Hospital of Taishan Medical University
2025
The First Affiliated Hospital, Sun Yat-sen University
2013-2024
Fudan University
2015-2024
Sun Yat-sen University
2013-2024
Zhongshan Hospital
2014-2024
National Clinical Research Center for Digestive Diseases
2022-2024
China Academy of Chinese Medical Sciences
2024
Shanghai Institute of Hematology
2024
Guilin University of Technology
2023
The predictors of in-hospital mortality for intensive care units (ICUs)-admitted heart failure (HF) patients remain poorly characterised. We aimed to develop and validate a prediction model all-cause among ICU-admitted HF patients.A retrospective cohort study.Data were extracted from the Medical Information Mart Intensive Care (MIMIC-III) database. Data on 1177 analysed.Patients meeting inclusion criteria identified MIMIC-III database randomly divided into derivation (n=825, 70%) validation...
The therapeutic effect of transplantation mesenchymal stem cells (MSCs) in myocardial infarction (MI) appears to be limited by poor cell viability the injured tissue, which is a consequence oxidative stress and pro-apoptotic factors. High density lipoprotein (HDL) reverses cholesterol transport has anti-oxidative anti-apoptotic properties. We, therefore, investigated whether HDL could protect MSCs from stress-induced apoptosis. derived bone marrow rats were pre-incubated with or without HDL,...
BACKGROUND Ischemic bowel disease (IBD) is a critical condition caused by reduced blood flow to the intestines, leading tissue damage and potentially severe complications. Early recognition timely management are essential for improving patient outcomes reducing morbidity mortality associated with IBD. AIM To evaluate knowledge, attitude practice (KAP) of healthcare professionals regarding METHODS This cross-sectional study was conducted among in China from November 2023 December using...
microRNA-210 (miR-210) has generally been reported to be associated with cell survival under hypoxia. However, there are few data regarding the role of miR-210 in mesenchymal stem cells (MSCs) oxidative stress conditions. Thus, we sought investigate whether over-expression could protect MSCs against injury and what primary mechanisms involved are. The results showed that significantly reduced apoptosis stress, accompanied by obvious increases viability superoxide dismutase activity...
Abstract Protection of cardiac microvascular endothelial cells (CMECs) against hypoxia injury is an important therapeutic strategy for treating ischaemic cardiovascular disease. In this study, we investigated the effects qiliqiangxin (QL) on primary rat CMECs exposed to and underlying mechanisms. Rat were successfully isolated passaged second generation. that pre‐treated with QL (0.5 mg/mL) and/or HIF‐1α siRNA cultured in a three‐gas hypoxic incubator chamber (5% CO 2 , 1% O 94% N ) 12...
Low density lipoprotein receptor-related protein 6 (LRP6), a wnt co-receptor, regulates multiple functions in various organs. However, the roles of LRP6 adult heart are not well understood. Methods: We observed expression with end-stage dilated cardiomyopathy (DCM) by western blot. Tamoxifen-inducible cardiac-specific knockout mouse was constructed. Hemodynamic and echocardiographic analyses were performed to these mice. Results: Cardiac dramatically decreased patients compared control...
Cardiac microvascular endothelial cells (CMECs) are important angiogenic components and injured rapidly after cardiac ischaemia anoxia. Cardioprotective effects of Qiliqiangxin (QL), a traditional Chinese medicine, have been displayed recently. This study aims to investigate whether QL could protect CMECs against anoxic injury explore related signalling mechanisms. were successfully cultured from Sprague-Dawley rats exposed anoxia for 12 hrs in the absence presence QL. Cell migration assay...
The present study was carried out to investigate the hypothesis that organic nitrates can attenuate senescence of mesenchymal stem cells (MSCs), a superior cell source involved in regeneration and repair damaged tissue. MSCs were treated with high glucose (HG) order induce senescence, which markedly attenuated by pre-treatment isosorbide dinitrate (ISDN), commonly used nitrate, as indicated senescence-associated galactosidase (SA-β-gal) activity, p21 expression, well mRNA levels DNA...
Abstract Qiliqiangxin (QL), a traditional Chinese medicine, had long been used to treat chronic heart failure. Recent studies revealed that differentiation of cardiac fibroblasts (CFs) into myofibroblasts played an important role in remodelling and development failure, however, little was known about the underlying mechanism whether QL treatment being involved. This study aimed investigate effects on angiotensin II (AngII)‐induced CFs transdifferentiation. Study performed vitro cultured from...
The present study is aimed at investigating whether Qiliqiangxin (QL) could regulate myocardial energy metabolism in heart failure rats after acute infarction (AMI) and further exploring the underlying mechanisms. AMI was established by ligating left anterior descending coronary artery adult male SD rats. with <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mtext>ejection</mml:mtext><mml:mtext> </mml:mtext><mml:mtext>fraction</mml:mtext><mml:mtext>...
Adiponectin is reported to relate with cardiovascular diseases, we sought examine whether adiponectin associated disease progression of heart failure from hypertension in rats comparison other known biomarkers and echocardiographic parameters. Spontaneously hypertensive (SHR, n = 35), aged 1 month, were used followed up 18 months. High frequency echocardiography was performed both at baseline every 3 months thereafter. Moreover, serum levels N-terminal pro-natriuretic peptide (NT-proBNP)...
Cardiac diastolic dysfunction has emerged as a growing type of heart failure. The present study aims to explore whether Qiliqiangxin (QL) can benefit cardiac function in spontaneously hypertensive rat (SHR) through enhancement glucose metabolism. Fifteen 12-month-old male SHRs were randomly divided into QL-treated, olmesartan-treated, and saline-treated groups. Age-matched WKY rats served normal controls. Echocardiography histological analysis performed. Myocardial uptake was determined by...