A5100379307- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Parkinson's Disease Mechanisms and Treatments
- Optical Imaging and Spectroscopy Techniques
- Traditional Chinese Medicine Studies
- MRI in cancer diagnosis
- Retinal Imaging and Analysis
- Medical Imaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Photoacoustic and Ultrasonic Imaging
- Medical Image Segmentation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Acute Ischemic Stroke Management
- Cardiovascular Disease and Adiposity
- Brain Tumor Detection and Classification
- Coronary Interventions and Diagnostics
- Neurological Disease Mechanisms and Treatments
- Advanced X-ray and CT Imaging
- Thermoregulation and physiological responses
- Radiation Dose and Imaging
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
Markey Cancer Center
2017-2025
University of Kentucky
2017-2025
Affiliated Hospital of North Sichuan Medical College
2021-2025
Fudan University
2009-2024
University of Washington
2012-2024
Aviation General Hospital
2024
University of Utah
2024
Huashan Hospital
2014-2024
Beijing Institute of Technology
2024
Beihang University
2024
The full range of long-term health consequences COVID-19 in patients who are discharged from hospital is largely unclear. aim our study was to comprehensively compare between 6 months and 12 after symptom onset among survivors with COVID-19.We undertook an ambidirectional cohort had been Jin Yin-tan Hospital (Wuhan, China) Jan 7 May 29, 2020. At 6-month 12-month follow-up visit, were interviewed questionnaires on symptoms health-related quality life (HRQoL), received a physical examination,...
Large multicenter studies validating the prognostic value of coronary computed tomographic angiography (CCTA) and left ventricular ejection fraction (LVEF) are lacking. We sought to confirm independent incremental artery disease (CAD) severity measured using 64-slice CCTA over LVEF clinical variables.A large international registry (CONFIRM Registry) was queried, patients with data on were screened. Patients a history myocardial infarction, revascularization, or cardiac transplantation...
Mutations in the neuronal protein α-synuclein cause familial Parkinson disease. Phosphorylation of at serine 129 is prominent disease and influences neurotoxicity. Here we report that also phosphorylated tyrosine 125 transgenic Drosophila expressing wild-type human this phosphorylation protects from neurotoxicity a model Western blot analysis fly brain homogenates showed levels soluble oligomeric species were increased by decreased phosphorylation. Tyrosine diminished during normal aging...
Background— Computed tomographic coronary angiography (CTA), given its high negative predictive value, is a potential gatekeeper for invasive (ICA). Before CTA can be further accepted into clinical practice, impact on healthcare resources needs to better understood. We sought determine the of ICA referrals, accuracy, and normalcy rate. Methods Results— To CTA, consecutive patients (n=7017) undergoing before after implementing dedicated cardiac CT program were reviewed compared with 3 other...
Mutations in PINK1 and PARKIN are the most common causes of recessive early-onset Parkinson's disease (EOPD). Together, mitochondrial ubiquitin (Ub) kinase cytosolic E3 Ub ligase direct a complex regulated, sequential quality control. Thereby, damaged mitochondria identified targeted to degradation order prevent their accumulation eventually cell death. Homozygous or compound heterozygous loss either gene function disrupts this protective pathway, though at different steps by distinct...
Purpose To develop a quantitative intracranial artery measurement technique to extract comprehensive features from time‐of‐flight MR angiography (MRA). Methods By semiautomatically tracing arteries based on an open‐curve active contour model in graphical user interface, 12 basic morphometric and 16 intensity for each were identified. Arteries then classified as one of 24 types using prediction probability model. Based the anatomical structures, integrated within 34 vascular groups regional...
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides a noninvasive method for evaluating tumor vasculature patterns based on contrast accumulation and washout. However, due to limited resolution tissue heterogeneity, tracer concentrations at many pixels often represent mixture of more than one distinct compartment. This pixel-wise partial volume effect (PVE) would have profound impact the accuracy pharmacokinetics studies using existing compartmental modeling (CM) methods....
Increased vascular stiffness is central to the pathophysiology of aging, hypertension, diabetes mellitus, and atherosclerosis. However, relatively few studies have examined in both thoracic abdominal aorta with despite major differences anatomy, embryological origin, relation aortic aneurysm.The 2 other unique features this study were (1) young (9±1 years) old (26±1 male monkeys (2) direct continuous measurements pressure diameters conscious monkeys. As expected, stiffness, β, was increased...
•Ultrafast ultrasound imaging is a new method to evaluate arterial stiffness with PWV.•The lack of reference values PWV has precluded its widespread clinical use.•This study established based on Han Chinese population.•Age, BP, and BMI were the dominant determinants PWV. BackgroundUltrafast been demonstrated be an effective carotid through pulse-wave velocity (PWV) high reproducibility, but use in practice. The aims this establish for ultrafast prospective, multicenter, population-based...
According to the WHO, anemia is a highly prevalent disease, especially for patients in emergency department. The pathophysiological mechanism by which can affect facial characteristics, such as membrane pallor, has been proven detect with help of deep learning technology. quick prediction method patient department important screen anemic state and judge necessity blood transfusion treatment. We trained system predict using videos 316 patients. All were taken same portable pad ambient...
To address many of the deficiencies in optical neuroimaging technologies, such as poor tempo-spatial resolution, low penetration depth, contact-based measurement, and time-consuming image reconstruction, a novel, noncontact, portable, time-resolved laser speckle contrast imaging (TR-LSCI) technique has been developed for continuous, fast, high-resolution 2D mapping cerebral blood flow (CBF) at different depths head. TR-LSCI illuminates head with picosecond-pulsed, coherent, widefield...
Significance: Cerebral blood flow (CBF) imaging is crucial for diagnosing cerebrovascular diseases. However, existing large neuroimaging techniques with high cost, low sampling rate, and poor mobility make them unsuitable continuous longitudinal CBF monitoring at the bedside. Aim: This study aimed to develop a low-cost, portable, programmable scanning diffuse speckle contrast (PS-DSCI) technology fast, high-density, depth-sensitive of in rodents. Approach: The PS-DSCI employed digital...
Previous researches have demonstrated that patients with subcortical ischemic vascular disease (SIVD) exhibited brain structure abnormalities. However, the cortical macrostructural and microstructural characteristics their relationship cognitive scores gene expression in SIVD remain largely unknown. This study collected 3D-T1 diffusion tensor imaging data from 30 impairment (SIVD-CI) 32 normal controls. The between-group comparative analyses of thickness, area, volume, local gyrification...