A5044226573- Cardiac Imaging and Diagnostics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Advanced MRI Techniques and Applications
- Parathyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Sarcoidosis and Beryllium Toxicity Research
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Medical Imaging and Pathology Studies
- Radiation Dose and Imaging
- COVID-19 and healthcare impacts
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peptidase Inhibition and Analysis
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Eosinophilic Disorders and Syndromes
- Cardiac electrophysiology and arrhythmias
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Healthcare cost, quality, practices
- Cardiomyopathy and Myosin Studies
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Society of Nuclear Medicine and Molecular Imaging
2013-2025
Cedars-Sinai Medical Center
2019-2024
University of Michigan
2014-2023
Soochow University
2023
Intermountain Healthcare
2023
Society of Interventional Radiology
2022
Stanford University
2021
Circle Cardiovascular Imaging
2021
Background— Cardiac transthyretin (ATTR) amyloidosis is a progressive and fatal cardiomyopathy for which several promising therapies are in development. The diagnosis frequently delayed or missed because of the limited specificity echocardiography traditional requirement histological confirmation. It has long been recognized that technetium-labeled bone scintigraphy tracers can localize to myocardial amyloid deposits, use this imaging modality cardiac ATTR lately revisited. We conducted...
Background— Impaired vasodilator function is an early manifestation of coronary artery disease and may precede angiographic stenosis. It unknown whether noninvasive assessment in patients with suspected or known carries incremental prognostic significance. Methods Results— A total 2783 consecutive referred for rest/stress positron emission tomography were followed up a median 1.4 years (interquartile range, 0.7–3.2 years). The extent severity perfusion abnormalities quantified by visual...
Coronary microvascular dysfunction (CMD) is a prevalent and prognostically important finding in patients with symptoms suggestive of coronary artery disease. The relative extent to which CMD affects both sexes largely unknown.We investigated 405 men 813 women who were referred for evaluation suspected disease no previous history visual evidence on rest/stress positron emission tomography myocardial perfusion imaging. flow reserve was quantified, <2.0 used define the presence CMD. Major...
Diabetes mellitus increases the risk of adverse cardiac outcomes and is considered a coronary artery disease (CAD) equivalent. We examined whether vascular dysfunction, an early manifestation CAD, accounts for increased among diabetics compared with nondiabetics.A total 2783 consecutive patients (1172 1611 nondiabetics) underwent quantification flow reserve (CFR; CFR=stress divided by rest myocardial blood flow) positron emission tomography were followed up median 1.4 years (quartile 1-3,...
Coronary microvascular ischaemia, cardiomyocyte injury and stiffness may play an important role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). To date, relationship between coronary flow reserve (CFR), myocardial injury, diastolic dysfunction, future HFpEF risk is unknown. Consecutive patients (n = 201) undergoing evaluation for suspected artery disease (CAD) stress perfusion positron emission tomography, serum troponin, transthoracic echocardiography who...
Background— Coronary flow reserve (CFR), an integrated measure of focal, diffuse, and small-vessel coronary artery disease (CAD), identifies patients at risk for cardiac death. We sought to determine the association between CFR, angiographic CAD, cardiovascular outcomes. Methods Results— Consecutive (n=329) referred invasive angiography after stress testing with myocardial perfusion positron emission tomography were followed (median 3.1 years) death heart failure admission. The extent...
Background— Although the value of coronary artery calcium (CAC) for atherosclerosis screening is gaining acceptance, its efficacy in predicting flow-limiting disease remains controversial, and incremental prognostic over myocardial perfusion not well established. Methods Results— We evaluated 695 consecutive intermediate-risk patients undergoing combined rest-stress rubidium 82 positron emission tomography (PET) imaging CAC scoring on a hybrid PET-computed (CT) scanner. The frequency...
Radionuclide myocardial perfusion imaging (MPI) is among the most commonly performed diagnostic tests in cardiology. Although and prognostic applications of radionuclide MPI are supported by a wealth observational clinical trial data, its performance limited two
Cardiovascular disease (CVD) fatality rates are higher for women than men, yet obstructive coronary artery (CAD) is less prevalent in women. Coronary flow reserve (CFR), an integrated measure of large- and small-vessel CAD myocardial ischemia, identifies patients at risk CVD death, but not routinely measured clinical practice. We sought to investigate the impact sex, CFR, angiographic severity on adverse cardiovascular events.Consecutive (n=329, 43% women) referred invasive angiography after...
Myocardial perfusion imaging has limited sensitivity for the detection of high-risk coronary artery disease (CAD). We tested hypothesis that a normal flow reserve (CFR) would be helpful excluding presence CAD on angiography.We studied 290 consecutive patients undergoing (82)Rb PET within 180 d invasive angiography. High-risk angiography was defined as 2-vessel (≥ 70% stenosis), including proximal left anterior descending artery; 3-vessel disease; or main 50% stenosis). Patients with prior Q...
Sarcoidosis is a systemic disorder of unknown etiology whose clinical presentation characterized by the heterogeneous contributions nonnecrotizing granulomatous inflammation and concomitant fibrosis. Cardiac involvement portends an adverse prognosis may account for approximately 25%
Background— Although cardiac magnetic resonance (CMR) and positron emission tomography (PET) detect different pathological attributes of sarcoidosis (CS), the complementary value these tests has not been evaluated. Our objective was to determine combining CMR PET in assessing likelihood CS guiding patient management. Methods Results— In this retrospective study, we included 107 consecutive patients referred for evaluation by both PET. Two experienced readers blinded all clinical data...
It is suggested that the integration of maximal myocardial blood flow (MBF) and coronary reserve (CFR), termed capacity, allows for comprehensive evaluation patients with known or suspected stable artery disease. Because management decisions are predicated on clinical risk, we sought to determine independent integrated value MBF CFR predicting cardiovascular death.MBF were quantified in 4029 consecutive (median age 66 years, 50.5% women) referred rest/stress perfusion positron emission...