A5044824487- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- Cardiac Arrest and Resuscitation
- Genetic Neurodegenerative Diseases
- Intensive Care Unit Cognitive Disorders
- Microtubule and mitosis dynamics
- Mechanical Circulatory Support Devices
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Multiple Sclerosis Research Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Health and Disease Prevention
- Infectious Encephalopathies and Encephalitis
- Immunotoxicology and immune responses
- Neuroscience of respiration and sleep
- Muscle Physiology and Disorders
- Drug-Induced Ocular Toxicity
- Powdery Mildew Fungal Diseases
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Poisoning and overdose treatments
- Sarcoidosis and Beryllium Toxicity Research
- Ultrasound in Clinical Applications
- Thermal Regulation in Medicine
- Medical Imaging Techniques and Applications
National Hospital for Neurology and Neurosurgery
2024
University College London
2015-2024
University of Calgary
2024
Imperial College Healthcare NHS Trust
2022-2023
Chelsea and Westminster Hospital NHS Foundation Trust
2023
Imperial College London
2020-2022
Boston Children's Hospital
2015-2021
Boston University
2016-2021
Massachusetts Institute of Technology
2017-2019
Pain and Rehabilitation Medicine
2019
Background— Cardiac transthyretin (ATTR) amyloidosis is a progressive and fatal cardiomyopathy for which several promising therapies are in development. The diagnosis frequently delayed or missed because of the limited specificity echocardiography traditional requirement histological confirmation. It has long been recognized that technetium-labeled bone scintigraphy tracers can localize to myocardial amyloid deposits, use this imaging modality cardiac ATTR lately revisited. We conducted...
The negative impact of smoking in multiple sclerosis is well established; however, there much less evidence as to whether cessation beneficial progression sclerosis. Adults with registered on the United Kingdom Multiple Sclerosis Register (2011-20) formed this retrospective and prospective cohort study. Primary outcomes were changes three patient-reported outcomes: normalized Physical Impact Scale (MSIS-29-Phys), Walking (MSWS-12) Hospital Anxiety Depression (HADS). Time event clinically...
In the search for a reliable, cooperation-independent, noninvasive alternative to invasive intracranial pressure (ICP) monitoring in children, various approaches have been proposed, but at present time none are capable of providing fully automated, real-time, calibration-free, continuous and accurate ICP estimates. The authors investigated feasibility validity simultaneously monitored arterial blood (ABP) middle cerebral artery (MCA) flow velocity (CBFV) waveforms derive (nICP)
Microtubules play a crucial role in the generation, migration and differentiation of nascent neurons developing vertebrate brain. Mutations constituents microtubules, tubulins, are known to cause an array neurological disorders, including lissencephaly, polymicrogyria microcephaly. In this study we explore genetic cellular mechanisms that TUBB5-associated microcephaly by exploiting two new mouse models: conditional E401K knock-in, knockout animal. These mice present with profound due loss...
Objective: A noninvasive intracranial pressure (ICP) estimation method is proposed that incorporates a model-based approach within probabilistic framework to mitigate the effects of data and modeling uncertainties. Methods: first-order model cerebral vasculature relates measured arterial blood (ABP) flow velocity (CBFV) ICP. The driven by ABP waveform solved for range mean ICP values predict CBFV waveform. resulting errors between predicted are transformed into likelihoods each candidate in...
Aciclovir-induced neurotoxicity results from the accumulation of aciclovir and its metabolite 9-carboxymethoxymethylguanine (CMMG). It occurs predominantly in older patients with impaired renal function is characterised by a combination confusion psychiatric changes. Seizures, myoclonus dysarthria may also occur. Critically, peritoneal dialysis has little effect on reversing toxic effects aciclovir. We describe woman her 70s failure who developed seizures after receiving She was ultimately...
Objectives: This study sought to assess the value of differing pre-operative measures in prediction post-operative non-surgical site infection (NSSI) and length hospital stay following hip fracture surgery. Methods: All patients admitted during a one year period with our department were included (n=207). Primary outcome ten independent risk factors correlated development surgery for fracture. Secondary duration inpatient mortality. Results: The who had severe cognitive impairment 71.0%...
Objectives: Time-averaged intracranial pressure-to-blood pressure Fisher-transformed Pearson correlation (PR x ) is used to assess cerebral autoregulation and derive optimal perfusion pressure. Empirically, impaired considered present when PR positive; greater difference between time series median ( Δ CPP associated with worse outcomes. Our aims are better understand: 1) the potential strategies for targeting pressure; 2) relationship ; 3) determinants of . Design: Mechanistic simulation...
Monitoring of intracranial pressure (ICP) is indicated in patients with a variety conditions affecting the brain and cerebrospinal fluid space. The measurement ICP, however, highly invasive as it requires placement catheter tissue or cerebral ventricular spaces. Several noninvasive techniques have been proposed to overcome this issue, one class approaches based on analyzing blood flow velocity (CBFV) arterial (ABP) waveforms infer ICP. Here, we analyze physiologic model linking ICP CBFV ABP...
Microtubules play a crucial role in the generation, migration and differentiation of nascent neurons developing vertebrate brain. Mutations constituents microtubules, tubulins, are known to cause an array neurological disorders, including lissencephaly, polymicrogyria microcephaly. In this study we explore genetic cellular mechanisms that TUBB5-associated microcephaly by exploiting two new mouse models: conditional E401K knock-in, knockout animal. These mice present with profound due loss...
<h3>Objective:</h3> To conduct a multi-centre audit on patient care in cohort of DM1 patients attending tertiary neuromuscular centres the UK, based 2018 consensus-based recommendations. assess impact an implementation change practice to improve access care. <h3>Background:</h3> Myotonic Dystrophy Type 1 (DM1) is most common muscular dystrophy adults. Structured multi-disciplinary essential for managing multi-system involvement safety and reduce mortality morbidity. Access can be variable...
<h3>ABSTRACT</h3> A 28-year-old man presented with a sudden onset of left leg pain and swelling. There was no history preceding trauma. Initial blood tests were unremarkable, ultrasound imaging showed extensive subcutaneous oedema. He then developed similar symptoms in his right leg, followed by both arms, finally forehead. fluctuating peripheral eosinophilia subsequently developed. Biopsies the arm forehead an evolving panniculitis. The clinical features, eosinophilia, histology consistent...
Myotonic Dystrophy Type 1 (DM1) is the most common muscular dystrophy in adults. Structured multi- disciplinary care required to manage multi-system involvement, improve patient safety, and reduce mortality morbidity. Previous audits based on 2018 consensus-based recommenda- tions have been conducted at individual UK centres. In this study a standardised audit tool was created deployed 3 tertiary neuroscience total, data regarding 375 patients (197 (53%) female, mean age 47 years (range...
Neurotoxicity is often a late consideration, particularly if the neurotoxic agent given with therapeutic intent, because poisoning occurs without diagnostic clues typical of an intentional attack. We present case 76 year old woman renal failure, who was admitted confusion and hal- lucinations. Several days previously, she had started Aciclovir vesicular rash. Her condition attributed to varicella zoster encephalitis switched from oral intravenous Aciclovir. Two later, after peritoneal...