A5003029116- Multiple Sclerosis Research Studies
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- Systemic Sclerosis and Related Diseases
- Facial Trauma and Fracture Management
- Diamond and Carbon-based Materials Research
- Craniofacial Disorders and Treatments
- Rheumatoid Arthritis Research and Therapies
- Oral microbiology and periodontitis research
- Family Support in Illness
- Vaccine Coverage and Hesitancy
- Cleft Lip and Palate Research
- Health Systems, Economic Evaluations, Quality of Life
- Metal and Thin Film Mechanics
- Medical and Biological Sciences
- Acute Lymphoblastic Leukemia research
- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
- Viral-associated cancers and disorders
- Anatomy and Medical Technology
- Artificial Intelligence in Healthcare and Education
- Orthodontics and Dentofacial Orthopedics
- HIV/AIDS oral health manifestations
- Spine and Intervertebral Disc Pathology
- Tumors and Oncological Cases
Swansea University
2018-2024
Vanderbilt University
2023
Royal Children's Hospital
2023
Landscape Research Group
2020
University College London
2015-2018
Barnet Hospital
2018
The Royal Free Hospital
2017-2018
University of Bristol
2014-2017
Great Ormond Street Hospital
2015-2017
University of Ulster
2015
Background: Higher education is associated with better job opportunities and higher income. Objectives: Herein, the impact of on uptake disease-modifying therapies (DMTs) for multiple sclerosis (MS) in a publicly funded health care system was examined using UK MS Register. Methods: All adult participants relapsing remitting diagnosed between 2008 2021 were included. Those without data regarding their levels excluded. Binary, multinomial Cox regression models used to examine association DMTs....
Purpose – The purpose of this paper is to investigate delay factors within private housing construction in Northern Ireland. Delays are inherent throughout the industry and create major difficulties terms project performance client satisfaction. Whilst a voluminous body international literature has investigated pertinent projects, there relative paucity research which offers more delineated exploration affecting development schemes, particularly UK context. Design/methodology/approach This...
The negative impact of smoking in multiple sclerosis is well established; however, there much less evidence as to whether cessation beneficial progression sclerosis. Adults with registered on the United Kingdom Multiple Sclerosis Register (2011-20) formed this retrospective and prospective cohort study. Primary outcomes were changes three patient-reported outcomes: normalized Physical Impact Scale (MSIS-29-Phys), Walking (MSWS-12) Hospital Anxiety Depression (HADS). Time event clinically...
Vaccines offer people with multiple sclerosis (PwMS) an effective protection against severe COVID-19 disease courses. However, representative real-world data on the tolerability of SARS-CoV-2 vaccines in PwMS are limited. We aimed at analysing vaccination reactions (VRs) and MS deterioration following vaccinations German United Kingdom (UK) PwMS, especially regarding gender-specific differences.The Multiple Sclerosis Society UK Registry acquired health via online system first (X1) second...
To assign a course of secondary progressive multiple sclerosis (MS) (SPMS) may be difficult and the proportion persons with SPMS varies between reports. An objective method for disease classification give better estimation relative proportions relapsing-remitting MS (RRMS) identify situations where is under reported.Data were obtained 61,900 patients from registries in Czech Republic, Denmark, Germany, Sweden, United Kingdom (UK), including date birth, sex, SP conversion year, visits an...
A three-dimensional kinetic Monte Carlo model has been developed to simulate the chemical vapor deposition of a diamond (100) surface under conditions used grow single-crystal (SCD), microcrystalline (MCD), nanocrystalline (NCD), and ultrananocrystalline (UNCD) films. The includes adsorption CHx (x = 0, 3) species, insertion CHy (y 0-2) into dimer bonds, etching/desorption both transient adsorbed species lattice sidewalls, incorporation, migration but not defect formation or renucleation...
In this paper, we briefly review the boxed molecular dynamics (BXD) method which allows analysis of thermodynamics and kinetics in complicated systems. BXD is a multiscale technique, long-time are recovered from set short-time simulations. previous applications to peptide cyclization, solution phase organic reaction desorption ions self-assembled monolayers (SAMs). We also report preliminary results simulations diamond etching mechanisms protein unfolding atomic force microscopy experiments....
The extent to which vibrational energy transfer dynamics can impact reaction outcomes beyond the gas phase remains an active research question. Molecular (MD) simulations are method of choice for investigating such questions; however, they be extremely expensive, and therefore it is worth developing cheaper models that capable furnishing reasonable results. This paper has two primary aims. First, we investigate competition between relaxation at 'hotspots' form on surface diamond during...
Abstract Understanding the associations and potential drivers of long-term disability in Multiple Sclerosis (MS) is clinical prognostic value. Previous data have suggested a link between depression accrual MS. We aimed to determine whether early MS predicts subsequent disability. Using from UK Register, we identified individuals with without symptoms anxiety close disease onset. used Cox proportional hazards regression evaluate depressive or predict physical worsening, measured using...
Registries have the potential to tackle some of current limitations in determining long-term impact multiple sclerosis. Online assessments using patient-reported outcomes can streamline follow-up enabling large-scale, long-term, cost-effective, home-based, and patient-focused data collection. However, registry are sparsely sampled sensitivity relative clinician-reported scales is unknown, making it hard fully leverage their unique scope scale derive insights. This retrospective prospective...
Quantum mechanical and hybrid quantum mechanical/molecular cluster models were used to investigate possible reaction mechanisms whereby gas-phase NHx (x = 0-2), CNHx 0, 1), OH radicals can add to, incorporate in, a C-C dimer bond on the C(100):H 2 × 1 diamond surface during chemical vapor deposition (CVD) from microwave-activated C/H containing gas mixtures trace amounts of added N or O. Three incorporation routes are identified, initiated by N, NH, CN(H) addition radical site, whereas only...
Background Incorporating cognitive testing into routine clinical practice is a challenge in multiple sclerosis (MS), given the wide spectrum of both and physical impairments people can have time that requires. Shortened paper verbal assessments predominate but still are not used routinely. Computer-based tests becoming more widespread; however, changes how test implemented impact what exactly being assessed an individual. The Symbol Digit Modalities Test (SDMT) one validated forms part...
Prescribing guidance for disease-modifying treatment (DMT) in multiple sclerosis (MS) is centred on a clinical diagnosis of relapsing-remitting MS (RRMS). DMT prescription guidelines and monitoring vary across countries. Standardising the approach to disease course, example, assigning RRMS or secondary progressive (SPMS) diagnoses, allows examination impact health system characteristics stated access.We analysed registry data from six cohorts five countries (Czech Republic, Denmark, Germany,...
To identify potential access to telemedicine follow-up of children with clefts operated on a humanitarian mission.A cross-sectional study parents presenting cleft lip and palate mission in Provincial Hospital the Philippines. A purpose designed questionnaire was used assess electronic digital resources that could be aid follow-up. Forty-five (N = 45) having primary or surgery participated. There were no interventions. Access Internet through Parent Perceived Affordability Owned...
Neurological conditions present with cognitive impairment that greatly affects the quality of life patients and should be routinely evaluated. However, it can difficult to detect impractical monitor classic in person assessment due limitations sensitivity, scalability cost. Internet- app-based tools for are a potential solution this problem, offering superior sensitivity being deliverable remotely context clinical registries, providing an acces- sible cost-effective way combine large-scale...