A5056144636- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Facial Trauma and Fracture Management
- Orthodontics and Dentofacial Orthopedics
- Bone Tissue Engineering Materials
- Bone health and osteoporosis research
- Orthopaedic implants and arthroplasty
- Cellular and Composite Structures
- History of Medical Practice
- Traumatic Brain Injury and Neurovascular Disturbances
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- dental development and anomalies
- Anatomy and Medical Technology
- Cellular Mechanics and Interactions
- Head and Neck Surgical Oncology
- Ocular Disorders and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Diamond and Carbon-based Materials Research
- Surface Modification and Superhydrophobicity
- Connective tissue disorders research
- Bone and Dental Protein Studies
- 3D Shape Modeling and Analysis
- Additive Manufacturing Materials and Processes
- Fatigue and fracture mechanics
Universidad de Navarra
2020-2024
Ikerbasque
2020-2024
Clinica Universidad de Navarra
2023
Great Ormond Street Hospital
2017-2020
University College London
2017-2020
Great Ormond Street Hospital for Children NHS Foundation Trust
2017-2020
Mondragon University
2018-2019
Institute of Child Health
2018
Royal London Hospital
2017
The Royal Free Hospital
2017
Triply periodic minimal surfaces (TPMS) are mathematically defined cellular structures whose geometry can be quickly adapted to target desired mechanical response (structural and fluid). This has made them desirable for a wide range of bioengineering applications; especially as bioinspired materials bone replacement. The main objective this study was develop novel analytical framework which would enable calculating permeability TPMS based on the architecture, pore size porosity. To achieve...
Background: Spring-assisted cranioplasty has been proposed as an alternative to total calvarial remodeling for sagittal craniosynostosis. Advantages include its minimally invasive nature, and reduced morbidity hospital stay. Potential drawbacks the need a second procedure removal lack of published long-term follow-up. The authors present single-institution experience 100 consecutive cases using novel spring design. Methods: All patients treated at authors’ institution between April 2010...
ABSTRACT Bone is a strong and tough material composed of apatite mineral, organic matter, water. Changes in composition organization these building blocks affect bone's mechanical integrity. Skeletal disorders often mineral phase, either by variations the collagen or directly altering mineralization. The aim current study was to explore differences brittle ductile cortical bone at (nm) tissue (µm) levels using two mouse phenotypes. Osteogenesis imperfecta model, oim-/-, mice have defect...
Repositioning of the maxilla in orthognathic surgery is carried out for functional and aesthetic purposes. Pre-surgical planning tools can predict 3D facial appearance by computing response soft tissue to changes underlying skeleton. The clinical use commercial prediction software remains controversial, likely due deterministic nature these computational predictions. A novel probabilistic finite element model (FEM) postoperative tissues proposed this paper. FEM was developed validated on a...
Three-dimensional (3D) imaging is an important tool for diagnostics, surgical planning, and evaluation of outcomes in craniofacial procedures. Gold standard acquiring 3D computed tomography that entails ionizing radiations and, young children, a general anaesthesia. photographic alternative method to assess patients who have undergone calvarial reconstructive surgery. The aim this study was the utility handheld scanning photography cohort underwent spring-assisted correction surgery...
Mechanical environment plays a crucial role in regulating bone regeneration defects. Assessing the mechanobiological behavior of patient-specific orthopedic scaffolds in-silico could help guide optimal scaffold designs, as well intra- and post-operative strategies to enhance improve implant longevity. Additively manufactured porous scaffolds, specifically triply periodic minimal surfaces (TPMS), have shown promising structural properties act substitutes, yet their ability induce...
During bone regeneration, the periosteum acts as a carrier for key regenerative cues, delivering osteochondroprogenitor cells and crucial growth factors to injured bone. We developed biocompatible, 3D polycaprolactone (PCL) melt electro-written membrane act mimetic periosteum. Poly (ethyl acrylate) coating of PCL allowed functionalization, mediated by fibronectin low dose recombinant human BMP-2 (rhBMP-2) (10-25 μg/ml), resulting in efficient, sustained osteoinduction vitro. In vivo, rhBMP-2...
Three-dimensional (3D) surface imaging devices designed to capture and quantify craniofacial morphology are becoming more common in clinical environments. Such scanners overcome the limitations of two-dimensional photographs while avoiding ionizing radiation computed tomography. The purpose this study was compare standard anthropometric cranial measurements with taken from images acquired 3D scanners. Two different cost were used acquire head shape data thirteen adult volunteers: M4D scan...
When analyzing intracranial volume gain resulting from operative intervention in craniosynostosis, it is necessary to understand the underlying growth. The authors sought create comprehensive and occipitofrontal circumference growth charts, as measured on unoperated craniosynostotic children, aimed investigate whether could act proxy measures for each other.All preoperative Great Ormond Street Hospital patients with a diagnosis of Apert, Crouzon-Pfeiffer, or Saethre-Chotzen syndrome year...
Trigonocephaly in patients with metopic synostosis is corrected by fronto-orbital remodelling (FOR). The aim of this study was to quantitatively assess aesthetic outcomes FOR capturing 3D forehead scans pre- and post-operatively comparing them controls. Ten single-suture undergoing 15 age-matched non-craniosynostotic controls were recruited at Great Ormond Street Hospital for Children (UK). Scans acquired a three-dimensional (3D) handheld camera post-processed combining imaging software....
OBJECTIVE Scaphocephaly secondary to sagittal craniosynostosis has been treated in recent years with spring-assisted cranioplasty, an innovative approach that leverages the use of metallic spring distractors reshape patient skull. In this study, a population patients who had undergone cranioplasty for correction scaphocephaly at Great Ormond Street Hospital Children was retrospectively analyzed systematically assess biomechanical performance and kinematics relation model, age, outcomes over...
Additively manufactured lattice structures enable the design of tissue scaffolds with tailored mechanical properties, which can be implemented in porous biomaterials. The adaptation bone to physiological loads results anisotropic properties are optimized for site-specific loads; therefore, some sites stiffer and stronger along principal load direction compared other orientations. In this work, a semi-analytical model was developed transversely isotropic that mimic anisotropy characteristics...
This study aimed at using eXtended finite element method (XFEM) to characterize crack growth through bone's intra-cortical pores. Two techniques were compared Abaqus: (1) void material properties assigned pores; (2) multiple enrichment regions with independent crack-growth possibilities employed. Both applied 2D models of transverse images mouse bone differing porous structures. Results revealed that assigning allows for cracks be initiated progressively, which cannot captured when the voids...
A hybrid approach combining the laser powder bed fusion (LPBF) process and post-processing operations through 5-axis milling was employed to manufacture a Ti6Al4V aerospace component. From design step, requirements needs in all stages of Hybrid Additive Manufacturing were taken into account. numerical simulation distortions promoted by residual stresses during additive consider material allowance. The status as-built post-processed component analysed scanning CMM inspection roughness...
The Melbourne technique was described in 2008 as a novel method for complete correction of scaphocephaly. Since 2015, it has become our operation choice children with sagittal synostosis who are too old at presentation minimally invasive techniques. Our modifications were 2-position (initially supine then prone) and undertaking formal fronto-orbital remodeling to correct forehead contour. Retrospective chart review used record demographics, blood transfusion frequency volumes, operating...
Abstract Sagittal craniosynostosis consists of premature fusion (ossification) the sagittal suture during infancy, resulting in head deformity and brain growth restriction. Spring-assisted cranioplasty (SAC) entails skull incisions to free fused insertion two springs (metallic distractors) promote cranial reshaping. Although safe effective, SAC outcomes remain uncertain. We aimed hereby obtain validate a material model for outcome prediction. Computed tomography data relative 18 patients...