A5000827962- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Bone fractures and treatments
- Bone Metabolism and Diseases
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Knee injuries and reconstruction techniques
- Assisted Reproductive Technology and Twin Pregnancy
- Osteoarthritis Treatment and Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related gene regulation
- Birth, Development, and Health
- Signaling Pathways in Disease
- Total Knee Arthroplasty Outcomes
- Calcium Carbonate Crystallization and Inhibition
- Advanced Drug Delivery Systems
- Dental Implant Techniques and Outcomes
- Graphene and Nanomaterials Applications
- Periodontal Regeneration and Treatments
- Protease and Inhibitor Mechanisms
- Collagen: Extraction and Characterization
- Additive Manufacturing and 3D Printing Technologies
- Orthopaedic implants and arthroplasty
- Heterotopic Ossification and Related Conditions
Clinica Universidad de Navarra
2014-2025
Universidad de Navarra
2019
Shanghai Cell Therapy Research Institute
2016
Universidad Panamericana
2012
The aim of the study was to determine long-term effect transplantation adipose-derived stromal cells (ADSCs) in a preclinical model ischemia/reperfusion (I/R). I/R induced 28 Goettingen minipigs by 120 min coronary artery occlusion followed reperfusion. Nine days later, surviving animals were allocated receive transendocardial injection mean 213.6 ± 41.78 million green fluorescent protein (GFP)-expressing ADSCs (n = 7) or culture medium as control 9). Heart function, cell engraftment, and...
During bone regeneration, the periosteum acts as a carrier for key regenerative cues, delivering osteochondroprogenitor cells and crucial growth factors to injured bone. We developed biocompatible, 3D polycaprolactone (PCL) melt electro-written membrane act mimetic periosteum. Poly (ethyl acrylate) coating of PCL allowed functionalization, mediated by fibronectin low dose recombinant human BMP-2 (rhBMP-2) (10-25 μg/ml), resulting in efficient, sustained osteoinduction vitro. In vivo, rhBMP-2...
Abstract Fracture nonunion is a major complication of bone fracture regeneration and repair. The molecular mechanisms that result in appearance are not fully determined. We hypothesized results from the failure hypoxia hematoma, primary signals response to injury, trigger Bmp2 expression by mesenchymal progenitor cells (MSCs). Using model nonstabilized healing transgenic 5′Bmp2BAC mice we determined appears close association with hypoxic tissue hematoma during early phases healing. In...
An attractive alternative to bone autografts is the use of autologous mesenchymal progenitor cells (MSCs) in combination with biomaterials. We compared therapeutic potential different sources stem biomaterials a nonunion model. A critical-size defect was created Sprague-Dawley rats. Animals were divided into six groups, depending on treatment be applied: left empty (CTL); treated live allograft (LBA); hrBMP-2 collagen scaffold (CSBMP2 ); acellular polycaprolactone (PCL group); PCL containing...
In the treatment of bone non-unions, an alternative to autografts is use morphogenetic proteins (BMPs), e.g., BMP–2, BMP–7, with powerful osteoinductive and osteogenic properties. clinical settings, these factors are applied using absorbable collagen sponges for local controlled delivery. Major side effects this strategy derived from supraphysiological doses BMPs needed, which may induce ectopic formation, chronic inflammation, excessive resorption. order increase efficiency delivered BMPs,...
This work identifies and describes different material-scaffold geometry combinations for cartilage tissue engineering (CTE). Previously reported potentially interesting scaffold geometries were tuned printed using bioresorbable polycaprolactone poly(lactide-b-ethylene) block copolymer. Medical grades of both polymers 3D with fused filament fabrication technology within an ISO 7 classified cleanroom. Resulting scaffolds then optically, mechanically biologically tested. Results indicated that...
The remodeling of the extracellular matrix is a central function in endochondral ossification and bone homeostasis. During secondary fracture healing, vascular invasion growth requires removal cartilage intermediate coordinate action collagenase metalloproteinase (MMP)-13, produced by hypertrophic chondrocytes, gelatinase MMP-9, cells hematopoietic lineage. Interfering with these MMP activities results impaired healing characterized accumulation delayed vascularization. MMP-10, Stromelysin...
was observed.
associated with the risk of falls but higher GDF-15 was poorer balance and slower gait speed (Pb0.001).Conclusions: Increased an increased hip fractures, suggesting that greater cell senescence increases fracture risk.This may not be attributable to lower BMD, perhaps poor while walking slowly causing are more likely impact hip.