A5085735975- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Facial Trauma and Fracture Management
- Reconstructive Facial Surgery Techniques
- Ocular Disorders and Treatments
- Burn Injury Management and Outcomes
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Wound Healing and Treatments
- Nasal Surgery and Airway Studies
- Facial Nerve Paralysis Treatment and Research
- Ear Surgery and Otitis Media
- Cardiac Arrest and Resuscitation
- Vascular Malformations and Hemangiomas
- Diabetic Foot Ulcer Assessment and Management
- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Congenital Ear and Nasal Anomalies
- Disaster Response and Management
- Anesthesia and Neurotoxicity Research
- Global Cancer Incidence and Screening
- Breast Lesions and Carcinomas
- Ovarian function and disorders
- History of Medical Practice
- Contact Dermatitis and Allergies
Concord Repatriation General Hospital
2019-2024
Great Ormond Street Hospital
2015-2023
University College London
2015-2023
The University of Sydney
2003-2023
Macquarie University
2023
University of Liverpool
2021
Society of Surgical Oncology
2021
Hospital Italiano de Buenos Aires
2021
Royal Brisbane and Women's Hospital
2021
Concord Hospital
2021
Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels that lead to stroke, life-threatening bleeds, disfigurement, overgrowth, and/or pain. Therapeutic options severely limited, and multidisciplinary management remains challenging, particularly for high-flow arteriovenous (AVM).To investigate the pathogenesis sporadic intracranial extracranial VMs in 160 children which known genetic causes had been excluded, we sequenced DNA from affected tissue optimized...
Genotype-phenotype studies can identify subgroups of patients with specific clinical features or differing outcomes, which help shape management.To characterize the frequency different causative genotypes in congenital melanocytic naevi (CMN), and to investigate genotype-phenotype genotype-outcome associations.We conducted a large cohort study we undertook MC1R genotyping from blood, high-sensitivity NRAS BRAF hotspots 156 naevus biopsies 134 CMN [male 40%; multiple 76%; projected adult size...
Background: Spring-assisted cranioplasty has been proposed as an alternative to total calvarial remodeling for sagittal craniosynostosis. Advantages include its minimally invasive nature, and reduced morbidity hospital stay. Potential drawbacks the need a second procedure removal lack of published long-term follow-up. The authors present single-institution experience 100 consecutive cases using novel spring design. Methods: All patients treated at authors’ institution between April 2010...
Mutations in the ERF gene, coding for ETS2 repressor factor, a member of ETS family transcription factors cause recently recognized syndromic form craniosynostosis (CRS4) with facial dysmorphism, Chiari‐1 malformation, speech and language delay, learning difficulties and/or behavioral problems. The overall prevalence mutations patients is around 2%, 0.7% clinically nonsyndromic craniosynostosis. Here, we present findings from 16 unrelated probands ERF‐related craniosynostosis, additional...
When analyzing intracranial volume gain resulting from operative intervention in craniosynostosis, it is necessary to understand the underlying growth. The authors sought create comprehensive and occipitofrontal circumference growth charts, as measured on unoperated craniosynostotic children, aimed investigate whether could act proxy measures for each other.All preoperative Great Ormond Street Hospital patients with a diagnosis of Apert, Crouzon-Pfeiffer, or Saethre-Chotzen syndrome year...
Trigonocephaly in patients with metopic synostosis is corrected by fronto-orbital remodelling (FOR). The aim of this study was to quantitatively assess aesthetic outcomes FOR capturing 3D forehead scans pre- and post-operatively comparing them controls. Ten single-suture undergoing 15 age-matched non-craniosynostotic controls were recruited at Great Ormond Street Hospital for Children (UK). Scans acquired a three-dimensional (3D) handheld camera post-processed combining imaging software....
Abstract Appearance and facial function are concepts not well addressed in current pediatric patient-reported outcome measures (PROM) for conditions. We aimed to develop a new module of the FACE-Q children/young adults with conditions that include ear anomalies, paralysis, skeletal conditions, soft tissue Semi-structured cognitive interviews were conducted patients aged 8–29 years recruited from craniofacial centers Canada, USA, UK, Australia. Interviews used elicit obtain feedback on...
The authors reviewed 21 patients who underwent triple pelvic osteotomy for severe Legg-Calvé-Perthes disease to evaluate their clinical, functional, and radiologic results. mean age at presentation was 7 years months (range 5-11 years). Seventeen hips were Herring group C 5 B. All of them had "at risk" signs. A new technique interlocking iliac used provide extra stability, allow early weight bearing, prevent inadvertent retroversion. average period follow-up 30 1-5 gain in Harris score 34.3...
Abstract Purpose Children affected by premature fusion of the cranial sutures due to craniosynostosis can present with raised intracranial pressure and (turri)brachycephalic head shapes that require surgical treatment. Spring-assisted posterior vault expansion (SA-PVE) is technique choice at Great Ormond Street Hospital for (GOSH), London, UK. This study aims report SA-PVE clinical experience GOSH date. Methods A retrospective review was carried out including all cases performed between 2008...
The CLEFT-Q includes 12 independently functioning scales that measure appearance (face, nose, nostrils, teeth, lips, jaws), health-related quality of life (psychological, social, school, speech distress), and function, an eating/drinking checklist. Previous qualitative research revealed the has content validity in noncleft craniofacial conditions. This study aimed to examine psychometric performance international sample patients with a broad range facial conditions.Data were collected...
Background: Patient-reported outcome measures are widely used to improve health services and patient outcomes. The aim of our study was describe the development 2 ear-specific scales designed measure outcomes important children young adults with ear conditions, such as microtia prominent ears. Methods: We an interpretive description qualitative approach. Semi-structured cognitive interviews were performed participants any type condition recruited from plastic surgery clinics in Canada,...
The FACE-Q Craniofacial Module is a patient-reported outcome measure designed for patients aged 8 to 29 years with conditions associated facial difference. In part 1, we describe the psychometric findings original CLEFT-Q scales tested in cleft and noncleft conditions. aim of this study was examine performance new scales.Data were collected between December 2016 2019 from visible or functional Rasch measurement theory (RMT) analysis used properties each scale. Scores transformed 0 (worst)...
The Melbourne technique was described in 2008 as a novel method for complete correction of scaphocephaly. Since 2015, it has become our operation choice children with sagittal synostosis who are too old at presentation minimally invasive techniques. Our modifications were 2-position (initially supine then prone) and undertaking formal fronto-orbital remodeling to correct forehead contour. Retrospective chart review used record demographics, blood transfusion frequency volumes, operating...
Abstract Sagittal craniosynostosis consists of premature fusion (ossification) the sagittal suture during infancy, resulting in head deformity and brain growth restriction. Spring-assisted cranioplasty (SAC) entails skull incisions to free fused insertion two springs (metallic distractors) promote cranial reshaping. Although safe effective, SAC outcomes remain uncertain. We aimed hereby obtain validate a material model for outcome prediction. Computed tomography data relative 18 patients...
Endoscopic strip craniectomy with helmeting (ESCH) has been shown to be a safe and efficacious alternative fronto-orbital remodeling (FOR) for selected children craniosynostosis. In addition clinical factors, there may economic benefits from the use of ESCH instead FOR.A retrospective review 23 patients nonsyndromic unicoronal craniosynostosis (UCS) treated FOR was carried out at Great Ormond Street Hospital (GOSH) Children in London, UK. Secondary data were used cohort paper published by...
Introduction The ear is a key facial feature and yet few studies have previously assessed aesthetics. This study aimed to assess the anatomical components of that greatest impact on perception Materials Methods Three photographs male adult (close-up, lateral, posterior) were digitally manipulated such in each, 1 element was either enlarged or reduced. A complete set 16 including repeat original as control randomized entered into an online survey required respondents rate attractiveness each...
Comparing complication rates between centres is difficult due to the lack of unanimous criteria regarding what adverse events should be defined as complications and how these compiled. This study analysed all in a cohort craniofacial (CF) operations over 10-year period applied three different scales (Clavien-Dindo, Leeds Oxford) for systematic comparison. A total 1023 consecutive CF procedures 641 patients was identified. The Clavien-Dindo scale captured 74 (7.2%), whereas Oxford 163 134...
Objective: The concepts important to children and young adults who undergo treatments for facial differences are not well-defined. Measurement of treatment outcomes from the patient’s perspective is necessary ensure goals met. We aimed identify with through a qualitative study. Design: An interpretive description approach was followed. Semistructured interviews were conducted, transcribed verbatim, coded using line-by-line approach. Qualitative analysis led development conceptual framework...
The main indication for hormone replacement therapy (HRT) is to control menopausal symptoms and improve quality of life. Ideally, withdrawal HRT should be attempted after 4-5 years therapy. reduces fracture risk remains appropriate osteoporosis, particularly in women with symptoms. not primary or secondary cardioprotection. leads a small increase breast cancer incidence, which increases duration age. the thromboembolism. Patient management reviewed annually risk-benefit counselling.
Arhinia (congenital absence of the nose) is a congenital rare disease, which has been reported in less than 60 cases literature. It consists external nose, nasal cavities and olfactory apparatus generally associated with midline defects, microphthalmia, blepharophimosis hypotelorism. Aesthetic problems as well functional anomalies can potentially impact on development interpersonal relationships child at later stage life. requires extensive management early life order to ensure airway...