A5091401005- Reconstructive Facial Surgery Techniques
- Ear Surgery and Otitis Media
- Cleft Lip and Palate Research
- Congenital Ear and Nasal Anomalies
- Nasal Surgery and Airway Studies
- Craniofacial Disorders and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Cutaneous Melanoma Detection and Management
- Ear and Head Tumors
- Tissue Engineering and Regenerative Medicine
- Tracheal and airway disorders
- Vascular Malformations and Hemangiomas
- Facial Nerve Paralysis Treatment and Research
- Vascular Malformations Diagnosis and Treatment
- melanin and skin pigmentation
- Genetic and rare skin diseases.
- Ocular Disorders and Treatments
- Mesenchymal stem cell research
- Tumors and Oncological Cases
- Facial Rejuvenation and Surgery Techniques
- Pluripotent Stem Cells Research
- Wound Healing and Treatments
- Orthopedic Surgery and Rehabilitation
- Melanoma and MAPK Pathways
- Head and Neck Anomalies
University College London
2016-2025
Great Ormond Street Hospital
2016-2025
Great Ormond Street Hospital for Children NHS Foundation Trust
2015-2025
Google (United States)
2024
Imperial College Healthcare NHS Trust
2021
University College Hospital
2019
Sohag University
2019
Erasmus MC
2019
Foghorn Therapeutics (United States)
2018
Blueprint Medicines (United States)
2018
Congenital melanocytic nevi (CMN) can be associated with neurological abnormalities and an increased risk of melanoma. Mutations in NRAS, BRAF, Tp53 have been described individual CMN samples; however, their role the pathogenesis multiple within same subject development features has not clear. We hypothesized that a single postzygotic mutation NRAS could responsible for individual, as well nonmelanocytic central nervous system (CNS) lesions. From 15 patients, 55 samples were sequenced after...
Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels that lead to stroke, life-threatening bleeds, disfigurement, overgrowth, and/or pain. Therapeutic options severely limited, and multidisciplinary management remains challenging, particularly for high-flow arteriovenous (AVM).To investigate the pathogenesis sporadic intracranial extracranial VMs in 160 children which known genetic causes had been excluded, we sequenced DNA from affected tissue optimized...
The aim of this report is to provide international recommendations for functional ear reconstruction in patients with microtia and aural atresia. All external auditory atresia should be seen the setting a multidisciplinary team agreed treatment outcomes measured, so that techniques, approaches, results can compared. methods are expert opinion from members International Microtia Atresia Workgroup (IMAW). consensus reported herein take into account variability practice patterns present among...
Genotype-phenotype studies can identify subgroups of patients with specific clinical features or differing outcomes, which help shape management.To characterize the frequency different causative genotypes in congenital melanocytic naevi (CMN), and to investigate genotype-phenotype genotype-outcome associations.We conducted a large cohort study we undertook MC1R genotyping from blood, high-sensitivity NRAS BRAF hotspots 156 naevus biopsies 134 CMN [male 40%; multiple 76%; projected adult size...
This study was undertaken to examine the feasibility of breast volume estimation as a predictor cosmetic outcome. We looked at result conservative surgery related percentage tissue removed. The excised calculated by comparing volume, from mammogram, and specimen volume. A total 24 patients were recalled special clinic assessed for their clinician, independent observer patient. assessment based on scale 1 4 (poor excellent). Our results show that if less than 20% removed, all assessors felt...
Augmentation of the nasal dorsum using autologous cartilage remains an exacting task in rhinoplasty. Precise, long-term control over graft contour and alignment can be difficult to achieve. In attempt alleviate these problems, use diced wrapped a supportive sleeve has recently seen resurgence interest. The Turkish delight technique uses Surgicel as material, whereas Daniel Calvert have proposed fascia.The objective this study was assess efficacy reliability cartilage-fascia grafts treatment...
Congenital melanocytic nevi (CMN) are pigmented birthmarks that affect up to 80% of the skin surface area. The increased frequency CMN in families severely affected individuals is suggestive a predisposing germline genotype. We noted high prevalence red hair families, and considered role for MC1R this condition. A cohort 166 subjects underwent pigmentary phenotyping, with genotyping 113. Results were compared local control group 60 unrelated children 300 UK without CMN. had higher...
Abstract Expression of major histocompatibility antigens class-2 (MHC-II) under non-inflammatory conditions is not usually associated with the nervous system. Comparative analysis immunogenicity human embryonic/fetal brain-derived neural stem cells (hNSCs) and mesenchymal neurogenic potential from umbilical cord (UC-MSCs) paediatric adipose tissue (ADSCs), while highlighting differences in their immunogenicity, led us to discover subsets co-expressing marker SOX2 MHC-II antigen vivo during...
Five cases of Wassel types III, IV and VII thumb duplication underwent a Bilhaut-Cloquet procedure. A stable mobile metacarpophalangeal joint was achieved in all cases. Interphalangeal motion limited but this The nail ridge these thumbs minimal. strong, normal size good appearance can result from the When one is 70% width, modified procedure using whole will avoid ridge, still differ normal.
Background: This study aims to assess the health-related quality-of-life benefit following auricular reconstruction using autologous costal cartilage in children. In addition, key aspects of surgical are assessed. Methods: After reconstruction, patients completed two questionnaires. The first was a postinterventional assessment tool, Glasgow Benefit Inventory. A score 0 signifies no change quality-of-life, +100 indicates maximal improvement, and –100 negative impact. second questionnaire...
Stem cells derived from adipose tissue are a potentially important source for autologous cell therapy and disease modeling, given fat accessibility abundance. Critical to developing standard protocols therapeutic use is thorough understanding of their potential, whether this consistent among individuals, hence, could be generally inferred. Such information still lacking, particularly in children. To address these issues, we have used different methods establish stem (adipose-derived [ADSCs],...