A5101894268- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Renal and Vascular Pathologies
- Organ and Tissue Transplantation Research
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Antenna Design and Analysis
- Noise Effects and Management
- Neurological Complications and Syndromes
- Hepatitis C virus research
- Urban Green Space and Health
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Pharmacological Effects and Toxicity Studies
- Corneal surgery and disorders
- Blood groups and transfusion
- Wind and Air Flow Studies
- T-cell and B-cell Immunology
- Vasculitis and related conditions
- Urban Heat Island Mitigation
- Mycobacterium research and diagnosis
Sun Yat-sen University
2015-2025
The First Affiliated Hospital, Sun Yat-sen University
2014-2024
Key Laboratory of Guangdong Province
2016-2024
Oregon State University
2018-2022
Guangzhou Medical University
2019
Guangzhou Women and Children Medical Center
2019
Sun Yat-sen Memorial Hospital
2019
Shandong First Medical University
2017
China Medical University
2012
Daqing Oilfield General Hospital
2010
High quality built environments are important for human health and wellbeing. Numerous studies have characterized environment physical features environmental exposures, but few examined urban perceptions at geographic scales needed population-based research. The degree to which associated with different features, traditional exposures such as air pollution or green space, is largely unknown.To determine factors safety, lively beauty across 56 cities.We collected in the open source Place...
Abstract Aim Long noncoding RNAs (lncRNAs) are novel intracellular ribonucleotides regulating the genome and proteome. The lncRNA activated by transforming growth factor β (TGF‐β) (lncRNA‐ATB) was discovered as a prognostic in hepatocellular carcinoma, gastric cancer, colorectal cancer. However, little is known about role of lncRNA‐ATB renal transplantation. This study aimed to assess expression transplant patients with acute kidney injury explore its postoperative pharmaceutical...
Postmenopausal osteoporosis (OPM) is a common type of in females. It systemic, chronic bone disease that presents as microstructure degradation osseous tissue, decreased mineral density and increased osteopsathyrosis caused by hypoovarianism reduced estrogen levels the body following menopause. In present study, role microRNA (miR)‑214‑5p regulation expression marrow stem cells (BMSCs) was investigated, its molecular mechanism osteogenic induction vitro assessed. When dexamethasone‑induced...
Background Elderly patients with end-stage renal disease have become the fastest growing population of kidney transplant candidates in recent years. However, risk factors associated long-term outcomes these remain unclear. Methods We retrospectively analyzed 166 recipients aged 60 years or older who underwent primary deceased transplantation between 2002 and 2013 our center. The main included 1-, 3- 5-year patient survival as well overall death-censored graft survival. independent affecting...
To compare the efficacy and safety of thymoglobulin compared with basiliximab in patients who had kidney transplants are at high risk for acute rejection delayed graft function.A retrospective review 1 or more factors function were given either induction therapy. Incidences rejection, antibody-treated function, chronic cancer, infection, leucopenia, thrombocytopenia between groups. Serum creatinine levels within year long-term patient survival also compared.A total 327 included....
Background Polyomavirus associated nephropathy (PVAN) is a significant cause of early allograft loss and the course difficult to predict. The aim this study identify factors influencing outcome for PVAN. Methods Between 2006 2014, we diagnosed PVAN in 48 (7.8%) 615 patients monitored BK virus every 1–4 weeks after modification maintenance immunosuppression. Logistic or Cox regression analysis were performed determine which risk independently affected clinical graft respectively. Results...
Abstract Background This study was designed to investigate the association between donor-derived cell-free DNA (dd-cfDNA) and renal allograft injuries. Methods single-center enrolled 113 adult kidney transplant recipients with biopsies. Plasma urine dd-cfDNA detected by target region capture sequencing. Results fraction increased in multiple types of injuries, but most significantly antibody-mediated rejection. isolated rejection (1.94%, IQR: 1.15%, 2.33%) higher than T cell-mediated (0.55%,...
Background: Studies have shown that plasma donor-derived cell-free DNA (dd-cfDNA) can predict renal allograft antibody-mediated rejection. This study was performed to evaluate the value of urine dd-cfDNA concentration and fraction (%) for discriminating BK polyomavirus-associated nephropathy (BKPyVAN) in kidney transplant recipients with urinary polyomavirus (BKPyV) infection. Methods: In this retrospective single-center observational study, we enrolled who were diagnosed BKPyV infection...
Aim: The aim of this study is to investigate the clinical features graft dysfunction following living kidney transplantation and assess its causes.Methods: We retrospectively analyzed a series 366 indication biopsies with clear etiology diagnosis from July 2003 June 2016 at our center. classifications diagnoses were performed based on pathological characteristics. All evaluated according Banff 2007 schema.Results: Acute rejection (AR) occurred in 85 cases (22.0%), chronic (CR) 62 (16.1%),...
To compare the efficacy and safety between rabbit anti-thymocyte globulin (Thymoglobulin) anti-T lymphocyte (ATG-Fresenius, ATG-F) in donation after cardiac death (DCD) kidney transplantation.We retrospectively analyzed 255 cases of DCD transplantation performed at our hospital from February 2007 to October 2013. The patients were divided into two groups based on their induction therapies with Thymoglobulin (n = 188) or ATG-F 67). Clinical data collected compared groups.Delayed graft...
Abstract Background To investigate predictive factors related to graft failure of IgA nephropathy(IgAN) in renal allografts following living donor transplantation. Methods We identified a series 102 biopsies diagnosed as IgAN transplantation from July 2004 January 2017 at our center, and assess the predict value Lee’s classification 2009 Oxford allografts, clinical, ultrasonic pathological characteristics biopsy outcomes were retrospectively analyzed. Results The 5-year cumulative survival...
Recipients of living donor renal transplantation are typically considered to have a relatively lower immunological risk. This retrospective study aimed compare the therapeutic efficacy and safety between rabbit antithymocyte globulin (rATG) or interleukin-2 receptor antagonist (IL2-RA) induction therapies in Chinese population.A total 188 patients receiving February 2004 December 2013 were included divided into rATG group based on their therapy. The primary outcome was clinically-suspected...
BK virus-associated nephropathy (BKVN) is an important cause of chronic allograft dysfunction. The objective our study was to evaluate the prognosis BKVN.We retrospectively reviewed data 133 renal transplant recipients with BKVN treated at First Affiliated Hospital Sun Yat-Sen University between July 2007 and 2017. viral loads, graft function, pathologic indexes were compared initial diagnosis last follow-up.After a mean follow-up period 14.4 (range, 0.3-109.6) months after BKVN, viruria,...
This study aimed to investigate the pathological characteristics of BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) with glomerular involvement in kidney transplant recipients.Forty-four patients BKPyV infection were retrospectively included for analysis. Immunohistochemical (IHC) staining was performed on paraffin sections using monoclonal mouse anti-SV40 large T antigen antibody.In BKPyV-infected glomeruli, parietal epithelial cells (GPECs) swollen, hyperchromatic, and enlarged,...
Kidneys from very small pediatric donors (≤10 kg) are underutilized. Compared to en bloc kidney transplantation (EBKT), single (SKT) can maximize donor resources. However, it remains unknown whether it's appropriate perform SKTs weighing ≤10 kg.A total of 35 adult recipients undergoing kg at our center December 2014 2019 were included and grouped into SKT group (n=20) EBKT (n=15). Transplant outcomes retrospectively analyzed compared between 2 groups.The 1-year 3-year death-censored graft...