A5100688627- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Natural Language Processing Techniques
- RNA Research and Splicing
- Advanced Computational Techniques and Applications
- Video Surveillance and Tracking Methods
- Educational Technology and Assessment
- Viral-associated cancers and disorders
- Face recognition and analysis
- Immune cells in cancer
- Machine Learning and Data Classification
- Speech Recognition and Synthesis
- Angiogenesis and VEGF in Cancer
- Text and Document Classification Technologies
- Adversarial Robustness in Machine Learning
- Speech and Audio Processing
- Animal Virus Infections Studies
- Topic Modeling
- interferon and immune responses
- Sesquiterpenes and Asteraceae Studies
- Microbial Natural Products and Biosynthesis
- Machine Learning and Algorithms
- Marine Sponges and Natural Products
Nanjing Medical University
2016-2025
Changzhou Third People's Hospital
2025
Union Hospital
2016-2022
Huazhong University of Science and Technology
2016-2022
Centenary Institute
2022
The University of Sydney
2022
The University of Melbourne
2020-2022
Yangtze University
2021
Xuzhou Medical College
2020
Second People’s Hospital of Huai’an
2020
Numerous studies have shown that long non-coding RNAs (lncRNAs) behave as a novel class of transcript during multiple cancer processes, such cell proliferation, apoptosis, migration, and invasion. LINC00152 is located on chromosome 2p11.2, has length 828 nucleotides. The biological role in LAD(lung adenocarcinoma) remains unknown.Quantitative reverse transcription PCR(qRT-PCR) was used to detect expression 60 human LAD tissues paired normal tissues. In vitro vivo showed the function tumour...
In this paper, we propose "personal VAD", a system to detect the voice activity of target speaker at frame level.This is useful for gating inputs streaming on-device speech recognition system, such that it only triggers user, which helps reduce computational cost and battery consumption, especially in scenarios where keyword detector unpreferable.We achieve by training VAD-alike neural network conditioned on embedding or verification score.For each frame, personal VAD outputs probabilities...
As a newly identified oncogenic long noncoding RNA (lncRNA), prostate cancer-associated transcript 6 (PCAT6) promoted cellular proliferation and colony formation of cancer. However, the biological function PCAT6 in lung cancer is still largely unknown. In this study, we found that significantly increased tissues compared to normal positively correlates with metastasis patients. We then examined expression cell lines was elevated cells human bronchial epithelial (NHBE) cells, especially CL1-5...
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is a gammaherpesvirus etiologically associated with KS, highly disseminated angiogenic tumor of hyperproliferative spindle endothelial cells. KSHV encodes 25 mature microRNAs but their roles in KSHV-induced dissemination and angiogenesis remain unknown. Here, we investigated KSHV-encoded miR-K12-6-3p (miR-K6-3p) promotion cell migration angiogenesis, which are the underlying mechanisms angiogenesis. We found that ectopic expression...
Kaposi's sarcoma (KS), a highly disseminated tumor of hyperproliferative spindle endothelial cells, is the most common AIDS-associated malignancy caused by infection sarcoma-associated herpesvirus (KSHV). KSHV-encoded viral interferon regulatory factor 1 (vIRF1) oncogene but its role in KSHV-induced invasiveness and motility remains unknown. Here, we report that vIRF1 promotes cell migration, invasion proliferation down-regulating miR-218-5p to relieve suppression downstream targets high...
Abstract Although a fraction of functional peptides concealed within long non‐coding RNAs (lncRNAs) is identified, it remains unclear whether lncRNA‐encoded are involved in the malignancy cervical cancer (CC). Here, 92‐amino acid peptide discovered, which named TUBORF, encoded by lncRNA TUBA3FP and highly expressed CC tissues. TUBORF inhibits ferroptosis to promote malignant proliferation cells. Mechanistically, human papillomavirus (HPV) oncogenes E6 E7 upregulate through CREB‐binding...
BACKGROUND Gastric cancer is one of the most common malignant tumors worldwide, with its incidence and mortality rates ranking among highest in gastrointestinal cancers. The overexpression or gene amplification human epidermal growth factor receptor 2 (HER-2) occurs approximately 15%-20% gastric cancers serves as a critical molecular target influencing prognosis treatment outcomes. For patients HER-2-positive cancer, trastuzumab combined platinum-based chemotherapy has been established...
Long noncoding RNAs (lncRNAs) have been shown to play important roles in various tumors including colorectal cancer (CRC). Here, we obtained data from RNA-sequencing analysis using 3 paired of CRC tissues and corresponding normal tissues. Through Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses, the biological functions these dysregulated genes were identified. Moreover, analyzed expression levels lncRNA PGM5-AS1 B3GALT5-AS1 by quantitative real-time PCR (qRT-PCR)...
Abstract Osteosarcoma (OS) is one of the most common primary bone malignancies and accounts for 3.4% pediatric tumors. Its 5-year survival as low about 20%. Differentially expressed lncRNAs in OS profiling were searched downloaded profile GSE12865. As a result, LINC00266-1 was detected to be upregulated both GSE12865 tissues we collected. SMAD2 downstream target binding promoter sites LINC00266-1, displaying positive regulatory interaction. Knockdown suppressed proliferative metastatic...
Long noncoding RNA (lncRNA) HOXC cluster antisense 3 (HOXC-AS3) has been involved in breast cancer and gastric cancer, while its role non-small cell lung (NSCLC) is unknown.The expression of HOXC-AS3 miR-96 (both mature premature) were detected using RT-qPCR. Nuclear fractionation assay pull-down performed to detect the subcellular location potential interaction with premature miR-96, respectively. Overexpression assays determine maturation miR-96. Transwell explore NSCLC invasion...
miR-203 has been indicated to be a tumor suppressor in esophageal cancer, however, the underlying molecular mechanisms by which it functions are not fully understood. The present study aimed investigate regulatory activities of microRNA (miR)-203 cancer. mimic/inhibitor, Mitogen-Activated Protein Kinase 1 (MAP3K1) overexpression plasmid and MAP3K1 small interfering (si)RNA were transfected into TE-1 cells. mRNA expression detected via reverse transcription-quantitative PCR analysis, while...
Abstract Background Since several long noncoding RNAs (lncRNAs) have been implicated in the development of chemoresistance non–small cell lung carcinoma (NSCLC), aim this study was to investigate whether antisense RNA INK4 locus (ANRIL) associated with NSCLC. Method Real‐time polymerase chain reaction performed identify potential lncRNAs involved NSCLC, while in‐silicon analyses and luciferase assays were carried out explore regulatory relationship among ANRIL, miR‐125a, aminopeptidase N...
Aiming at the human face detection in color images under complex background, a method based on combination of skin model YCgCr and AdaBoost algorithm is proposed this article. Firstly, it uses space to detect candidate region tested image, then further verifies by Adaboost with added new feature. Experimental results show that can effectively improve efficiency background significantly reduce false rate.
We propose a novel, lightweight supervised dictionary learning framework for text classification based on data compression and representation. This two-phase algorithm initially employs the Lempel-Ziv-Welch (LZW) to construct from datasets, focusing conceptual significance of elements. Subsequently, dictionaries are refined considering label data, optimizing atoms enhance discriminative power mutual information class distribution. process generates numerical representations, facilitating...