Shan Zhang

ORCID: 0009-0005-2501-6038
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About
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Research Areas
  • Parasitic Infections and Diagnostics
  • interferon and immune responses
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Atherosclerosis and Cardiovascular Diseases
  • Immune Response and Inflammation
  • Inflammasome and immune disorders
  • Amoebic Infections and Treatments
  • Viral gastroenteritis research and epidemiology
  • Sepsis Diagnosis and Treatment
  • Immune cells in cancer
  • Reproductive System and Pregnancy
  • Gout, Hyperuricemia, Uric Acid
  • Helminth infection and control
  • Lipid Membrane Structure and Behavior
  • Adipokines, Inflammation, and Metabolic Diseases
  • Antimicrobial Peptides and Activities
  • Dietary Effects on Health
  • Ginkgo biloba and Cashew Applications
  • Aquaculture disease management and microbiota
  • IL-33, ST2, and ILC Pathways
  • Cerebrovascular and genetic disorders
  • Biological Stains and Phytochemicals
  • Cytomegalovirus and herpesvirus research
  • Hematological disorders and diagnostics
  • Traditional Chinese Medicine Analysis

Nanjing University of Chinese Medicine
2022-2025

Inner Mongolia Agricultural University
2023-2025

Shanghai Medical College of Fudan University
2025

Zhongshan Hospital
2025

Peking University
2024

Qingdao Agricultural University
2024

Shandong First Medical University
2022

Wuhan University
2022

Shandong University
2022

Henan Provincial People's Hospital
2021

Mito-SEPs are small open reading frame-encoded peptides that localize to the mitochondria regulate metabolism. Motivated by an intriguing negative association between mito-SEPs and inflammation, here we screen for modify inflammatory outcomes report a mito-SEP named "Modulator of cytochrome C oxidase during Inflammation" (MOCCI) is upregulated inflammation infection promote host-protective resolution. MOCCI, paralog NDUFA4 subunit (Complex IV), replaces in Complex IV lower mitochondrial...

10.1038/s41467-021-22397-5 article EN cc-by Nature Communications 2021-04-09

Formononetin (FMNT), a flavonoid identified from the Chinese herb Astragalus membranaceus, possesses anti-inflammatory or anti-oxidative properties in different human diseases. This study aims to comprehensively elucidate function of FMNT atherosclerosis and its underlying mechanisms. Online public databases were used identify drug-disease targets. Protein-protein interaction (PPI), Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment applied explore potential...

10.1080/21655979.2021.1959493 article EN Bioengineered 2021-01-01

Enterocytozoon bieneusi is a zoonotic pathogen, with cattle serving as major reservoirs and important mediums for its transmission. However, data on the prevalence subtypes of E. in from Northern Shanxi Central Inner Mongolia, China, are limited. This study aimed to evaluate risk associated North Mongolia Connection Area. In this study, internal transcribed spacer (ITS) gene bieniusi was assessed. Fecal samples (n = 1338) were randomly collected 15 intensive free-range farms between 2021...

10.1038/s41598-025-91848-6 article EN cc-by-nc-nd Scientific Reports 2025-02-25

Ginkgolide B is a herbal constituent extracted from leaves of the ginkgo biloba tree. Previous studies have shown that ginkgolide specific platelet activating factor (PAF) receptor antagonist, and it suppresses PAF-mediated activation via competitive binding. In this study, effect on nicotinamide adenine dinucleotide phosphate oxidase other inflammatory proteins in ox-LDL (low-density lipoprotein)-stimulated human vascular endothelial cells was investigated. Another PAF antagonist CV3988...

10.1097/fjc.0b013e31821a50a8 article EN Journal of Cardiovascular Pharmacology 2011-03-25

Cryptosporidium is a gastrointestinal protozoan that widely exists in nature, it an established zoonotic pathogen. Infected cattle are considered to be associated with cryptosporidiosis outbreaks humans. In the present study, we aimed assess prevalence and species distribution of dairy Central Inner Mongolia.We focused on small subunit ribosomal RNA gene (SSU rRNA) 60-kDa glycoprotein (gp60) parvum. We collected 505 manure samples from 6 sampling sites Mongolia 2021; were divided into 4...

10.1186/s12917-023-03696-z article EN cc-by BMC Veterinary Research 2023-08-25

Type IV interferon (IFN) has been shown to be a cytokine with antiviral activity in fish and amphibian. But, it not cloned characterized functionally avian species. In this study, type IFN, IFN-υ, its 2 possible receptors, IFN-υR1 IL10RB, were identified from an species, the mallard (Anas platyrhynchos). Mallard IFN-υ 531 bp open reading frame (ORF), encoding 176 amino acids (aa), highly conserved features as reported different N-terminal signal peptide predicted multi-helix structure. The...

10.1016/j.psj.2024.103673 article EN cc-by-nc-nd Poultry Science 2024-03-16

Aspirin has antithrombotic activity and is commonly used to protect patients from cardiovascular disease attacks. The present study investigated whether aspirin reduces reactive oxygen species proinflammatory proteins in oxidized low-density lipoprotein (ox-LDL)-stimulated human umbilical vein endothelial cells. results showed that attenuated generation induced by ox-LDL downregulated Nox4 inducible nitric oxide synthase expression. Redox-sensitive transcription factor nuclear kappa B was...

10.1097/fjc.0b013e318248acba article EN Journal of Cardiovascular Pharmacology 2012-01-04

Giardia duodenalis is a gastrointestinal protozoan ubiquitous in nature. It confirmed zoonotic pathogen, and cattle are considered source of giardiasis outbreaks humans. This study aimed to evaluate the prevalence multilocus genotype (MLG) G. dairy Central Inner Mongolia. was based on small subunit ribosomal RNA (SSU rRNA), glutamate dehydrogenase (gdh), triosephosphate isomerase (tpi), beta-giardin (bg) genes duodenalis. DNA extraction, polymerase chain reaction (PCR), sequence analysis...

10.1038/s41598-023-40987-9 article EN cc-by Scientific Reports 2023-08-26

Abstract Minimal persistent inflammation (MPI), the local that occurs after an acute type II immune response in patients with allergic rhinitis (AR), is responsible for airway hyperreactivity and recurrence of AR. Innate lymphoid cells (ILCs) play a crucial role mucosal homeostasis, but changes ILC subsets MPI stage remain unclear. In this study, levels ILC-secreting cytokines nasal lavages were analyzed from 19 AR 8 healthy volunteers. model mice established to study subsets. The results...

10.1002/jlb.3ma0822-436rr article EN Journal of Leukocyte Biology 2022-09-26

Glioblastoma is a grade IV glioma with the highest degree of malignancy and extremely high incidence. Because poor therapeutic effect surgery radiochemotherapy, glioblastoma has recurrence rate lethality, one most challenging tumors in field oncology. Ethyl pyruvate (EP), stable lipophilic pyruvic acid derivative, anti-inflammatory, antioxidant, immunomodulatory other cellular protective effects. It been reported that EP potent anti-tumor effects on many types tumors, including pancreatic...

10.7717/peerj.9559 article EN cc-by PeerJ 2020-07-21
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