A5100412168- Spine and Intervertebral Disc Pathology
- Cancer Mechanisms and Therapy
- Mesenchymal stem cell research
- Musculoskeletal pain and rehabilitation
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Advanced Memory and Neural Computing
- Neuroscience and Neural Engineering
- Lymphoma Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Tea Polyphenols and Effects
- Chronic Lymphocytic Leukemia Research
- Cervical and Thoracic Myelopathy
- Signaling Pathways in Disease
- Pelvic and Acetabular Injuries
- Peptidase Inhibition and Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Spinal Hematomas and Complications
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
- Tryptophan and brain disorders
- Phytochemicals and Antioxidant Activities
- Cardiac Fibrosis and Remodeling
- Histone Deacetylase Inhibitors Research
- Shoulder Injury and Treatment
Affiliated Hospital of Guizhou Medical University
2019-2024
Guiyang Medical University
2019-2024
Nanjing University
2010-2024
Nanjing General Hospital of Nanjing Military Command
2024
Third Hospital of Hebei Medical University
2019-2024
Hebei Medical University
2019-2024
Qingdao University of Science and Technology
2024
Yunnan Agricultural University
2023
Shenzhen University Health Science Center
2021
Army Medical University
2014-2021
The integrity of the fluid-blood barrier in stria vascularis is critical for maintaining inner ear homeostasis, especially sustaining endocochlear potential, an essential driving force hearing function. However, mechanisms that control intrastrial permeability remain largely unknown. At cellular level, comprises cochlear microvascular endothelial cells connected to each other by tight junctions (TJs), underlying basement membrane, and a second line support consisting pericytes perivascular...
To describe a new approach for the application of polymethylmethacrylate augmentation bone cement-injectable cannulated pedicle screws.Between June 2010 and February 2013, 43 patients with degenerative spinal disease osteoporosis (T-score <-2.5) underwent lumbar fusion using screws. Clinical outcomes were evaluated Visual Analog Scale Oswestry Disability Index. Patients given radiographic follow-up examinations after 3, 6, 12 months once per year thereafter.All followed mean 15.7 ± 5.6...
Abstract The enhanced osteogenesis of mesenchymal stem cells (MSCs) modified by expression cytotoxic T lymphocyte-associated antigen 4 (CTLA4) has been shown in previous studies, but the mechanism remains unknown. Here we found that bone repair effect CTLA4 -modified MSCs demineralized matrix (DBM) a rabbit radius defect model was significantly better than observed for unmodified DBM or alone, and periostin (POSTN) higher both vivo vitro. In addition, also treatment with soluble POSTN could...
Abstract Translationally controlled tumor protein (TCTP/TPT1) was identified from a yeast 2-hybrid screen and shown to interact with Pim-3, member of the proto-oncogene Pim family serine/threonine kinase activity. TCTP aberrantly expressed in human pancreatic cancer cells malignant ductal epithelial cells, but not normal duct adjacent foci tissue. Moreover, colocalized Pim-3 both clinical tissues. Mapping studies revealed that interaction between occurred through C-terminal region N-terminal...
The authors designed a modified lateral lumbar interbody fusion (LLIF) procedure named as XOLIF and compared the efficacy safety with traditional LLIF procedures.Patients were divided into XLIF, OLIF, group according to surgical approach. Cases of psoas major vascular space stenosis, muscle elevation, hypertrophy, high iliac crest recorded. Basic information, composition ratio specific cases, Visual analog scale (VAS), Oswestry Disability Index (ODI), rate complications between 3 groups.The...
To compare the clinical efficacy of a new retractor-assisted Wiltse transforaminal lumbar interbody fusion (TLIF), minimally invasive TLIF (MIS-TLIF), and traditional posterior (PLIF) in treating single-level degenerative diseases.A retrospective study was conducted by analyzing imaging data consecutive patients with diseases who underwent TLIF, MIS-TLIF, or PLIF. This enrolled 87 concurrent between June 2016 December 2019 (Wiltse 29 cases; MIS-TLIF 28 PLIF 30 cases). The three groups were...
The present study was conducted with an attempt to explore the overall efficacy of large-channel spinal endoscopy technology in elderly patients segmental lumbar stenosis.
Abstract Objectives The role of vitamin D ( VD ) in innate and adaptive immune responses to tuberculosis is still unclear. Our research was aimed uncover the effect on Th17 cells elucidate potential molecular mechanism. Materials methods VDR ‐deficient wild‐type mice were used obtain CD 4 T cells. induced activated by Bacillus Calmette Guerin. Flow cytometry analyse apoptosis rate degree differentiation treatment 1,25( OH 2 3 . interaction between P65 Rorc determined immunofluorescence...
Abstract Clinically, bone marrow mesenchymal stem cells (BMSCs) have been used in treatment of many diseases, but the local oxidative stress (OS) lesion severely limits survival BMSCs, which reduces efficacy BMSCs transplantation. Therefore, enhancing anti‐OS ability is a key breakthrough point. Preconditioning common protective mechanism for or body. Here, aim this study was to investigate effects OS preconditioning on and its mechanism. Fortunately, can increase expression superoxide...
To evaluate the safety and efficacy of a novel bone cement-injectable cannulated pedicle screw augmented with polymethylmethacrylate in osteoporotic spinal surgery.This study included 128 patients osteoporosis (BMD T-score -3.2±1.9; range, -5.4 to -2.5) who underwent decompression instrumentation polymethylmethacrylate-augmented screw. Postoperative Visual Analogue Scale scores Oswestry Disability Index were compared preoperative values. plain radiographs computed tomography (CT) scans...
Abstract Oxidative stress damage is a common problem in bone marrow mesenchymal stem cell (BMSC) transplantation. Under conditions, the mitochondrial function of BMSCs disrupted, which accelerates senescence and apoptosis BMSCs, ultimately leading to poor efficacy. Therefore, improving enhancing antioxidative capacity may be an effective way survival rate curative effect BMSCs. In present study, we have confirmed that overexpression nicotinamide mononucleotide adenylyl transferase 3 (NMNAT3)...
Hypoxia-induced apoptosis of bone marrow mesenchymal stem cells (BMSCs) limits the efficacy their transplantation for steroid-induced osteonecrosis femoral head (SONFH). As and RNA methylation are closely related, exploring role mechanism in hypoxic BMSCs is expected to identify new targets SONFH enhance efficacy. We performed methylated immunoprecipitation sequencing (MeRIP-seq) combined with RNA-seq on a hypoxia-induced BMSC model found that methyltransferase-like 3 (METTL3) involved...
Abstract Objective To investigate the effects of low-concentration hydrogen peroxide pretreatment on anti-oxidative stress bone marrow mesenchymal stem cells (BMSCs). Methods Rabbit BMSCs were isolated and cultured by density gradient centrifugation combined with adherence method. Then, third generation well-grown was continuously treated 50-μM (H 2 O ) for 8 h as optimal concentration applied 24 500 μM H , damage determined oxidative cell model. The experiment divided into three groups:...
Cytotoxic T lymphocyte-associated antigen 4-Ig (CTLA4-Ig)-modified bone marrow-derived mesenchymal stem cells (MSCs-CTLA4) have excellent osteogenic function in xenografts, but their mechanism of action remains to be elucidated. As bidirectional signaling between erythropoietin-producing hepatocyte receptors B4 (EphB4) and ephrinB2 is vital for remodeling, this study aimed fully characterize the role MSCs-CTLA4 promoting regeneration xenotransplantation through EphB4/ephrinB2 cross talk with...