A5100396699- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Signaling Pathways in Disease
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- RNA Research and Splicing
- Immune Response and Inflammation
- Head and Neck Cancer Studies
- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Protein Kinase Regulation and GTPase Signaling
- Telomeres, Telomerase, and Senescence
- Cancer Research and Treatments
Sun Yat-sen University
2014-2025
Sun Yat-sen University Cancer Center
2014-2025
Second Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
First Affiliated Hospital of Xiamen University
2022-2024
Qilu Hospital of Shandong University
2021-2024
Fujian Medical University
2022-2024
University of California, Davis
2022-2024
UC Davis Comprehensive Cancer Center
2024
Zhongshan People's Hospital
2024
Reprogrammed energy metabolism as an emerging hallmark of cancer has recently drawn special attention since it facilitate cell growth and proliferation. Recently, long noncoding RNAs (lncRNAs) have been served key regulators implicated in tumor development progression by promoting proliferation, invasion metastasis. However, the associations lncRNAs with cellular lung (LC) need to be clarified. Here, we conducted bioinformatics analysis found insulin-like factor binding protein 4–1...
Abstract Colorectal cancer, one of the most commonly diagnosed cancers worldwide, is often accompanied by uncontrolled proliferation tumor cells. Dyskerin pseudouridine synthase 1 (DKC1), screened using genome‐wide RNAi strategy, a previously unidentified key regulator that promotes colorectal cancer cell proliferation. Enforced expression DKC1, but not its catalytically inactive mutant D125A, accelerates growth in vitro and vivo. DKC1 knockdown or inhibitor pyrazofurin attenuates...
Colorectal cancer (CRC) is the third most common cause of deaths, and has a high rate liver lung metastasis. Unfortunately, distant metastasis main barrier for advanced CRC therapy leads to very low survival rate. In this study, we identified WDR5, vital factor that regulates vertebrate development cell self-renewal reprogramming, as novel prognostic marker therapeutic target patients. We demonstrate WDR5 upregulated in tissues promotes both vitro vivo. an effort investigate impact on fate,...
Purpose This study was conducted to evaluate the prognostic value of treatment-related lymphopenia in patients with nasopharyngeal carcinoma (NPC). Materials and Methods A total 413 consecutive stage II-IVb NPC treated concurrent chemoradiotherapy (CCRT) were enrolled. The overall survival (OS), progression-free (PFS), distant metastasis-free (DMFS) calculated Kaplan-Meier method, differences compared using log-rank test. Results minimum (mini)–absolute lymphocyte counts (ALC) < 390 cells/μL...
The main challenge for immune checkpoint blockade (ICB) therapy lies in immunosuppressive tumor microenvironment (TME). Repolarizing M2-like tumor-associated macrophages (TAMs) into inflammatory M1 phenotype is a promising strategy cancer immunotherapy. Here, this study shows that the suppressive protein SHISA3 regulates antitumor functions of TAMs. Local delivery mRNA encoding Shisa3 enables immunotherapy by reprogramming TAMs toward an antitumoral phenotype, thus enhancing efficacy...
Abstract Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, which a heterogeneous disease and main risk factors are associated with inflammation, family history, genetic mutations, epigenetics, so on. Ring finger domain proteins have been reported involved in carcinogenesis, whereas their roles CRC rarely studied. Here, we reanalyzed expression 202 RNF members using published microarray data from GEO database found that RNF183 markedly upregulated tumor tissues....
// Huiming Chen 1,2 , Shijuan Gao 1 Jiandong Li Dong Liu Chunjie Sheng Yao Wei Jiang Jiaoxiang Wu Shuai 1,3 and Wenlin Huang 1,3,4 CAS Key Laboratory of Pathogenic Microbiology Immunology, Institute Microbiology, Chinese Academy Sciences, Beijing 100101, China 2 School Life Anhui University, Hefei 230039, 3 Sun Yat-sen University Cancer Center, State Oncology in South China, Collaborative Innovation Center for Medicine, Guangzhou 510060, 4 The Tumor Targeted Medicine Guangdong Province,...
// Changping Wu 1, * , Xin Jin 2, Jing Yang 2 Yinhui Yundong He Liya Ding Yunqian Pan Shuai Chen 5 Jingting Jiang 1 Haojie Huang 3, 4 Department of Tumor Biological Treatment, The Third Affiliated Hospital Soochow University, Changzhou 213003, China Biochemistry and Molecular Biology, Mayo Clinic College Medicine, Rochester, MN 55905, USA 3 Urology, Cancer Center, Sun Yat-sen University State Key Laboratory Oncology in South China, Collaborative Innovation Center Guangzhou 510060, These...
Influenza A viruses (IAVs) rely on host factors to support their life cycle, as viral proteins hijack or interact with cellular execute functions. Identification and understanding of these would increase our knowledge the molecular mechanisms manipulated by viruses. In this study, we searched for novel binding partners influenza virus NS2 protein, nuclear export protein responsible overcoming range restriction, a yeast two-hybrid screening assay glutathione S-transferase-pulldown...
Icariin is a prenylated flavonol glycoside derived from the Chinese herb Epimedium sagittatum that exerts variety of pharmacological activities and shows promise in treatment prevention Alzheimer's disease. In this study, we investigated neuroprotective effects icariin against amyloid beta protein fragment 25-35 (Aβ 25-35) induced neurotoxicity cultured rat pheochromocytoma PC12 cells explored potential underlying mechanisms. Our results showed dose-dependently increased cell viability...
Background Osteoarthritis (OA) is a prevalent chronic joint disease for which there lack of effective treatments. In this study, we used Mendelian randomization analysis to identify circulating proteins that are causally associated with OA-related traits, providing important insights into potential drug targets OA. Method Causal associations between 1553 and five traits were assessed in large-scale two-sample MR analyses using Wald ratio or inverse variance weighting, the results corrected...
Mounting evidence has demonstrated the genetic association of ORMDL3 (ORMDL Sphingolipid Biosynthesis Regulator 3) gene polymorphisms with bronchial asthma and a diverse set inflammatory disorders. However, its role in type I interferon (IFN) signaling remains poorly defined. Herein, we report that is negative modulator IFN by interacting MAVS (Mitochondrial Antiviral Signaling protein) subsequently promoting proteasome-mediated degradation RIG-I (Retinoic Acid-Inducible Gene I)....
Mounting evidence has demonstrated the genetic association of ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) gene polymorphisms with bronchial asthma and a diverse set inflammatory disorders. However, its role in type I interferon (type IFN) signaling remains poorly defined. Herein, we report that ORMDL3 is negative modulator IFN by interacting mitochondrial antiviral protein (MAVS) subsequently promoting proteasome-mediated degradation retinoic acid-inducible (RIG-I)....
ABSTRACT DNA vaccines offer advantage over conventional vaccines, as they are safer to use, easier produce, and able induce humoral well cellular immune responses. Unfortunately, no have been licensed for human use the difficulties in developing an efficient safe vivo gene delivery system. In electroporation (EP)-based has attracted great attention its potency enhance uptake of function adjuvant. Minicircle (a new form containing only a expression cassette lacking backbone bacterial plasmid...
Uncontrolled growth and distant metastasis are hallmarks of colorectal cancer (CRC), but the mechanisms poorly understood. Olfactomedin 1 (OLFM1), a member olfactomedin domain-containing protein family, plays an important role in development neurogenic tissues. Recently, OLFM1 deregulation was frequently observed several cancers, it induced colon cell lines after treatment with demethylating agent 5-aza-2'-deoxycytidine. However, function CRC remains unknown. In this study, we reanalysed...
Xuanwei City is located in late Permian coal-accumulating areas of the northeastern region Yunnan Province. In China, morbidity and mortality from lung cancer are highest Yunnan. Identifying useful circulating markers suitable for diagnosis this quite meaningful. study, we evaluated diagnostic roles serum miR-9-5p, 21-5p, 223-3p, 135b-5p, 339-5p, 501-5p patients with non-small-cell (NSCLC) Moreover, performance several tumor markers, including carcinoembryonic antigen (CEA), cytokeratin 19...
Abstract Background Lung cancer is one of the most widely spread cancers in world and half non-small cell lung are adenocarcinoma (LUAD). Although there were several drugs been approved for LUAD therapy, a large portion still cannot be effectively treated due to lack available therapeutic targets. Here, we investigated oncogenic roles DKC1 its potential mechanism explored possibility targeting therapy. Methods The Gene Expression Omnibus (GEO) Cancer Genome Atlas Program (TCGA) databases...
Hypopharyngeal squamous cell carcinoma (HSCC) is a kind of head and neck (HNSCC) with poor prognosis. Metabolic reprogramming may regulate the tumor microenvironment (TME) by adapting quickly to cellular stress regulating immune response, but its role in HSCC has not been reported. We used nCounter ® Pathways Panel investigate metabolic reprogramming, stress, their relationship tissues adjacent normal tissues. Metabolism-related pathways nucleotide synthesis glycolysis were significantly...