A5100628246- Bioinformatics and Genomic Networks
- Aquatic Ecosystems and Phytoplankton Dynamics
- Coastal wetland ecosystem dynamics
- Gene Regulatory Network Analysis
- Epigenetics and DNA Methylation
- Gene expression and cancer classification
- Innovative Microfluidic and Catalytic Techniques Innovation
- Air Quality and Health Impacts
- Genetic Associations and Epidemiology
- Plant and animal studies
- Plant Parasitism and Resistance
- Land Use and Ecosystem Services
- Cancer Immunotherapy and Biomarkers
- Marine and coastal ecosystems
- Luminescence and Fluorescent Materials
- Isotope Analysis in Ecology
- Congenital heart defects research
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Air Quality Monitoring and Forecasting
- Microfluidic and Capillary Electrophoresis Applications
- Nanoplatforms for cancer theranostics
- Craniofacial Disorders and Treatments
- Nitrogen and Sulfur Effects on Brassica
- Circular RNAs in diseases
Chinese Academy of Sciences
2011-2025
University of Chinese Academy of Sciences
2019-2025
Shanghai Institute of Materia Medica
2019-2025
Oil Crops Research Institute
2023-2024
Chinese Academy of Agricultural Sciences
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Guiyang Medical University
2024
Xiamen University
2024
Jinan University
2024
Tongde Hospital of Zhejiang Province
2023
The targeted delivery of a photosensitizer (PS) with appropriate carriers represents an attractive means selectively delivering cargo to target tissues or subcellular compartments for photodynamic therapy (PDT). Herein, three-arm distyryl BODIPY derivative conjugated mannose units (denoted by BTM) that can co-assemble Tween 80 form nanomicelles (BTM-NMs) PDT is reported. MDA-MB-231 breast cancer cells recognized and specifically internalized BTM-NMs via mannose-receptor-mediated endocytosis...
The targeted delivery of a photosensitizer (PS) into specific cancer cells is an effective way to enhance the efficacy and minimize side effects photodynamic therapy. Herein, heptamannosylated β-cyclodextrin (β-CD) was used mediate formation adamantane (Ad)-functionalized BODIPY PS nanoparticle via strong β-CD/Ad complexation. mannose-functionalized nanoparticles are selectively internalized by mannose-receptor-rich MDA-MB-231 breast receptor-mediated endocytosis, facilitating singlet oxygen...
Metastatic triple-negative breast cancer (TNBC) is the most aggressive type of cancer. Combination systemic chemotherapy and immune checkpoint blockade effective but limited benefit due to insufficient intratumoral infiltration cytotoxic T lymphocytes (CTLs) accumulation immunosuppressive cells. Herein, we designed a lenvatinib- vadimezan-loaded synthetic high-density lipoprotein (LV-sHDL) for combinational immunochemotherapy metastatic TNBC. The LV-sHDL targeted scavenger receptor class B...
In the realm of clinical practice, concurrent utilization anticancer medications can enhance their overall therapeutic efficacy. However, it is crucial to acknowledge that interactions among these drugs potentially yield detrimental consequences on intended outcomes. Consequently, assessment both potency and potential toxic side effects greatly refined when multiple are simultaneously detected evaluated. Here, we designed a wearable electrochemical aptasensor array for monitoring in sweat....
Enhancers, as specialized genomic cis-regulatory elements, activate transcription of their target genes and play an important role in pathogenesis many human complex diseases. Despite recent systematic identification them the genome, currently there is urgent need for comprehensive annotation databases enhancers with a focus on disease connections. In response, we built Human Enhancer Disease Database (HEDD) to facilitate studies potential roles HEDD provides information ∼2.8 million...
Schizophrenia is a severe mental disorder with large genetic component. Recent genome-wide association studies (GWAS) have identified many schizophrenia-associated common variants. For most of the reported associations, however, underlying biological mechanisms are not clear. The critical first step for their elucidation to identify likely disease genes as source signals. Here, we describe general computational framework post-GWAS analysis complex gene prioritization. We 132 putative...
The efficacy of cancer immunotherapy relies on a sufficient amount functional immune cells. Triple-negative breast lacks enough cell infiltration, and adjuvant therapy is necessary to prime anti-tumor immunity. However, the improvement in unsatisfactory with concern about inducing systemic immunotoxicity. Herein, we create an abemaciclib-loaded supramolecular peptide hydrogel formed by peptide-drug amphiphiles for neoadjuvant triple-negative cancer, where amphiphile conjugate β-sheet-forming...
It has been reported that the PI3K/AKT signaling pathway is activated in diffuse large B-cell lymphoma (DLBCL), PI3K constitutive activation plays a crucial role pathway. However, copy number variations (CNVs) of subunits on gene level remain unknown DLBCL. Therefore, aim study to investigate CNV and their relationship with clinicopathological features exploring possible mechanism underlying 12 genes was detected by NanoString nCounter 60 de novo DLBCLs 10 reactive hyperplasia specimens as...
Multiple drug resistance (MDR) and metastasis are two major factors that contribute to the failure of cancer treatment. However, relationship between MDR has not been characterized. Additionally, role E3 ubiquitin ligase Cbl-b in gastric breast is well known. In present study, we found cells possess a typical mesenchymal phenotype enhanced cell migration capacity. poorly expressed cells. adenocarcinoma tissues, patients with low expression were more likely have tumor invasion (P = .016)...
Although studies over the last decades have firmly connected a number of genes and molecular pathways to aging, aging process as whole still remains poorly understood. To gain novel insights into mechanisms underlying instead considering individually, we studied their characteristics at systems level in context biological networks. We calculated comprehensive set network for human aging-related from GenAge database. By comparing them with other functional groups genes, identified robust...
Malignant breast cancer with complex molecular mechanisms of progression and metastasis remains a leading cause death in women. To improve diagnosis drug development, it is critical to identify panels genes pathways involved tumor malignant transition. Using the PyMT mouse, genetically engineered mouse model that has been widely used study human cancer, we profiled analyzed gene expression from four distinct stages (hyperplasia, adenoma/MIN, early carcinoma late carcinoma) during which...
Sporadic colon cancer accounts for approximately 80% of colorectal (CRC) with high incidence in Western societies strongly linked to long-term dietary patterns. A unique mouse model sporadic CRC results from feeding a purified rodent Western-style diet (NWD1) recapitulating intake the common nutrient risk factors each at its level consumed higher populations. This causes large and small intestinal tumors wild-type mice an frequency similar that humans. NWD1 perturbs cell maturation Wnt...
Sini decoction (SND) is a widely used Traditional Chinese Medicine (TCM). The reports of SND application in colorectal cancer (CRC) limited.The objective this study to investigate the anti-tumor activity treatmeant CRC.SND was analyzed using high-performance liquid chromatography. A CRC metastasis model established murine CT-26 cells. Whole-body fluorescence imaging observe liver metastasis. Liver morphology determined hematoxylin-eosin staining. Cytokine mRNA expression (interleukin-2...
Mitochondria-associated membranes (MAMs) are essential to mitochondria. This study was determine whether endotoxemia rearranges MAMs in the heart, and Beclin-1 regulates this process. Wild-type mice with a cardiac-specific overexpression of (Becn1-Tg), or heterozygous knockout (Becn1+/−) were given lipopolysaccharide (LPS) challenge. In ultrastructure examined by electron microscopy histology evaluated immunostaining. Additionally, isolated ultracentrifugation, their content function...
Rapeseed (Brassica napus L.) is one of the main oil crops in world, and increasing its yield great significance for ensuring safety edible oil. Presently, improving rapeseed plant architecture an effective way to increase with higher planting density. However, regulatory mechanism poorly understood. In this study, a dwarf mutant dwarf08 (df08) obtained by ethyl methane sulfonate (EMS)-mutagenesis. The decrease height df08 mainly caused reduction inflorescence length first branch controlled...
Rhizoma Pinelliae is the dried tuber of Pinellia ternata (Thunb.) Breit. Modern pharmacological studies have shown that has antitussive, antiemetic, glandular secretion inhibiting and antitumor effects.To optimize processing technology Praeparatum, to study its anti-tumor effect.Orthogonal design method was applied analyze effects factors such as licorice concentration volume, soaking time temperature on Praeparatum; MTT assay flow cytometry were used determine inhibitory effect Praeparatum...
Eutrophication in aquatic ecosystem is known to cause an intensification of primary production, with consequences for the degradation. Various researches provided evidences about food web structure variations during eutrophication process, but there were few attempts empirically investigate relationship between energy availability and trophic relationships, which important goal relevance management eutrophic lakes. As a large shallow lake, Lake Taihu has suffered long‐term eutrophication....
The protein ARHGDIA has been found to play distinct roles in cancer progression for several tumors. However, it remains elusive whether and how plays functions human glioma. In this study, we discovered that is much downregulated glioma; meanwhile, its expression negatively correlates with glioma malignancy positively relates prognosis of patients. It independent predictive value level overall survival Glioma patients ARHGDIA-positive have a longer time than ARHGDIA-negative Knockdown...
MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression their target genes. Numerous studies have shown that miRNAs not only key regulators in important cellular processes but also drivers development many diseases, especially cancer. Estrogen receptor positive luminal B is second most common least studied subtype breast Only a few examined profiles cancer, and regulatory roles cancer progression yet be investigated.In this...